The makers of Hebrew books in Italy : being chapters in the history of the Hebrew printing press

by David Werner Amram

The menorah : from Theodore Herzl ; for solo, tenor or soprano, violin and piano ; with 4 texts: Hebrew, Jewish, English and German

composed by A. Haitmann

The Ghetto song : Rachel oh Rachel ; for solo, tenor or soprano, violin and piano ; with 4 texts: Hebrew, Jewish, English and German

composed by A. Haitmann. [Words] from Hugo Zuckermann

Some notes on the use of Hebrew type in Non-Hebrew books, 1475 - 1520

by Alexander Marx

Selections From Popular Hebrew Operas. Melz Josher. Opus 1, 2 und Klaviersatz

Für Klavier solo, ohne Gesang und ohne Text

Selections from Popular Hebrew Operas. Gehenim and Ganeiden.Opus 1. und 2. Quartette und Duet

Für Klavier solo, ohne Gesang und ohne Text

The influence of Gesenius on Hebrew lexicography

New York, Diss.

Post-biblical Hebrew literature : an anthology

by B. Halper

A short account of the Hebrew tenses

by R. H. Kennett

Catalogue of an important collection of Hebrew manuscripts, lately collected in Palestine

by Nathan Coronel [[Elektronische Ressource]]

The leveler of the path : hebrew reader and translator for the use of schools

by S. Mannheimer

The Hebrew woman

by Constance de Rothschild [[Elektronische Ressource]] ; aus: The New Quarterly Magazine, Vol. 5. 1876

In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

Intravital imaging has revealed that T cells change their migratory behavior during physiological activation inside lymphoid tissue. Yet, it remains less well investigated how the intrinsic migratory capacity of activated T cells is regulated by chemokine receptor levels or other regulatory elements. Here, we used an adjuvant-driven inflammation model to examine how motility patterns corresponded with CCR7, CXCR4, and CXCR5 expression levels on ovalbumin-specific DO11.10 CD4(+) T cells in draining lymph nodes. We found that while CCR7 and CXCR4 surface levels remained essentially unaltered during the first 48-72 h after activation of CD4(+) T cells, their in vitro chemokinetic and directed migratory capacity to the respective ligands, CCL19, CCL21, and CXCL12, was substantially reduced during this time window. Activated T cells recovered from this temporary decrease in motility on day 6 post immunization, coinciding with increased migration to the CXCR5 ligand CXCL13. The transiently impaired CD4(+) T cell motility pattern correlated with increased LFA-1 expression and augmented phosphorylation of the microtubule regulator Stathmin on day 3 post immunization, yet neither microtubule destabilization nor integrin blocking could reverse TCR-imprinted unresponsiveness. Furthermore, protein kinase C (PKC) inhibition did not restore chemotactic activity, ruling out PKC-mediated receptor desensitization as mechanism for reduced migration in activated T cells. Thus, we identify a cell-intrinsic, chemokine receptor level-uncoupled decrease in motility in CD4(+) T cells shortly after activation, coinciding with clonal expansion. The transiently reduced ability to react to chemokinetic and chemotactic stimuli may contribute to the sequestering of activated CD4(+) T cells in reactive peripheral lymph nodes, allowing for integration of costimulatory signals required for full activation.