Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial

Cognitive function in postmenopausal women receiving letrozole or tamoxifen as adjuvant endocrine treatment was compared during the fifth year of treatment in a substudy of the BIG 1-98 trial. In BIG 1-98 patients were randomized to receive adjuvant (A) 5-years tamoxifen, (B) 5-years letrozole, (C) 2-years tamoxifen followed by 3-years letrozole, or (D) 2-years letrozole followed by 3-years tamoxifen. The primary comparison was the difference in composite score for patients taking letrozole (B+C; N=65) vs. tamoxifen (A+D; N=55). The patients taking letrozole had better overall cognitive function than those taking tamoxifen (difference in mean composite z-scores=0.28, P=0.04, 95% CI: 0.02, 0.54, Cohen's D=0.40 indicating small to moderate effect). In this substudy, breast cancer patients taking adjuvant letrozole during the fifth year of treatment had better cognitive function than those taking tamoxifen, suggesting aromatase inhibitors do not adversely impact cognition compared with tamoxifen.

Jan Fook: Social Work: Critical Theory and Practice & Karen Healy: Social Work Practices: Contemporary Perspectives on Change

In his recent book on the contemporary politics of social work, Powell (2001) nominates Jan Fook and Karen Healy as two Australian authors who have made significant contributions to the radical or critical social work tradition. I have chosen to review them together, as each, in different ways, attempts to achieve the same purpose. That is, they attempt to provide a convincing account for adopting a critical approach to practice in the contemporary conditions of the 21st century and, in doing so, re-invigorate the radical tradition of social work practice. My first comment, important for the readership of this international journal, is that both books easily 'travel' beyond the Australian context.

Book Review of “At Risk: Social Justice in Child Welfare and Other Human Services” by Karen J. Swift and Marilyn Callahan, 2009, Toronto: University of Toronto Press

The newest book by Canadian social work scholars Karen Swift and Marilyn Callahan is exemplary of how other disciplines can invigorate social work theory. “At Risk” uses child welfare practice as an entry point for exploring the continuing movement away from addressing needs and towards the management of risk in the human services.

William Harvey revisited

William Harvey's discovery of the circulation of the blood is often described as a product of the Scientific Revolution of the Seventeenth Century. Modern research has, however, shown thatHarvey followed the Aristotelian research tradition and thus tried to reveal the purpose of the organs through examination of various animals. His publication of 1628 has to be read as an argument of natural philosophy, or, more precisely, as a series of linked observations, experiments and philosophical reasonings from which the existence of circulation has to be deduced as a logical consequence. Harvey did not consider experiments as superior to philosophical reasoning nor intended he to create a new system of medicine. He believed in the vitality of the heart and the blood and rejected Francis Bacon's empirism and the mechanistic rationalism of Descartes. Harvey's contribution and originality lied less in his single observations and experiments but in the manner how he linked them with critical reasoning and how he accepted, presented and defended the ensuing radical findings.

Hedi Höpfner, Margot Höpfner, Lilian Harvey, Szenenfoto, Gruppenbildnis, in: Karl Ritter: Capriccio, 1938

Signatur des Originals: S 36/F11582

La justicia social y la utopía dialéctica : discutiendo con Harvey sobre espacio público

Este trabajo explora la idea de justicia social y, teniendo en cuenta el papel del espacio público, el pensamiento utópico de David Harvey sobre el futuro de las ciudades. Este conocido geógrafo inglés, que vive en EE.UU., dedica su vida a construir una teoría del desarrollo geográfico desigual con el objeto de elaborar propuestas alternativas que empiecen un proceso continuo de cambios progresistas en busca de una sociedad más justa. En "Espacios de esperanza", Harvey (2000) considera críticamente utopías de dos tipos: de forma espacial y de proceso social. La primera incluye las propuestas por Owen, Fourier, Howard, Corbusier, Wright y Jacobs – a pesar de que se opongan o complementen entre sí – pero en el contexto de las ciudades contemporáneas, las producidas por diversos agentes de la suburbanización de EE.UU en las ciudades de disneylandización de las ciudades con centros comerciales, la revitalización de los centros de las ciudades, en las utopías de condominios privados y otros.

Caso Karen Llantoy v. Perú. Documento No. CCPR/C/85/D/1153/2003

http://www.cdh.uchile.cl/libros/dh-mujeres/21llantoy.pdf

La presencia del mal en la ciencia ficción española. Un homenaje a Karen Capek

Fil: Krakovic, Diana Estela. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Lectures on plant physiology. Authorized English translation by R.J. Harvey Gibson.

main vol.

Phycologia australica; or, A history of Australian sea weeds ... and a synopsis of all known Australian Algae ... By William Henry Harvey.

1

Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribonucleotide adducts

The aim of the present study is to determine the chemical structure and conformation of DNA adducts formed by incubation of the bioactive form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), N-acetoxy-PhIP, with a single-stranded 11mer oligodeoxyribonucleotide. Using conditions optimized to give the C8-dG-PhIP adduct as the major product, sufficient material was synthesized for NMR solution structure determination. The NMR data indicate that in duplex DNA this adduct exists in equilibrium between two different conformational states. In the main conformer, the covalently bound PhIP molecule intercalates in the helix, whilst in the minor conformation the PhIP ligand is probably solvent exposed. In addition to the C8-dG-PhIP adduct, at least eight polar adducts are found after reaction of N-acetoxy-PhIP with the oligonucleotide. Three of these were purified for further characterization and shown to exhibit lowest energy UV absorption bands in the range 342–347 nm, confirming the presence of PhIP or PhIP derivative. Accurate mass determination of two of the polar adducts by negative ion MALDI-TOF MS revealed ions consistent with a spirobisguanidino-PhIP derivative and a ring-opened adduct. The third adduct, which has the same mass as the C8-dG-PhIP oligonucleotide adduct, may contain PhIP bound to the N2 position of guanine.