Triple G girls get going in tennis : resource manual

Physical activity is ranked second in importance only to tobacco control in health promotion and disease prevention in Australia. Individuals can be active in many ways every day, including –walking to and/or from school, work and other places of interest; participating in sports clubs; going to the YMCA or community leisure centre where you can be active through gyms, group fitness classes or in the swimming pool; visiting local parks and walking trails, and even at home and in the backyard. You can always find ways to be active in the community.

Promoting physical activity to young people is important for developing healthy lifestyles now and maintaining them for the future. A physically active lifestyle can be of benefit to physical, mental and social health. Despite these benefits, adolescent girls and young women are considerably less active than their male counterparts, and sport participation decreases dramatically among girls during their secondary school years. Many physical education teachers have also expressed concern about girls minimising their participation in school physical education. Consequently, it is timely that a project such as Triple G ‘Girls Get Going in Tennis, in Football, and at the YMCA’ should be developed and implemented in an effort to arrest the decline in girls’ participation in sport, physical activity and physical education.

The Triple G program aims to develop, implement and evaluate a program to promote participation in physical activity by girls in rural and regional schools and communities. The impact of the Triple G program on the mental and physical wellbeing of the girls will also be evaluated. The program specifically aims to create school and community linkages through the introduction of tennis coaches, football coaches, and YMCA instructors into the physical education class to team teach with physical education staff during the 2011 school year. As part of the school-based program, Year 7 – 9 girls will participate in a YMCA unit and one of tennis or football during their physical education classes (6 sessions x 100mins each). Each unit is then followed by an eight week afterschool program at the local tennis or football club, or YMCA centre.

História ambiental no Brasil: o percurso historiográfico de Warren Dean

Pós-graduação em História - FCLAS

Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study.

BACKGROUND Clinical prognostic groupings for localised prostate cancers are imprecise, with 30-50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors. METHODS We used DNA-based indices alone or in combination with intra-prostatic hypoxia measurements to develop four prognostic indices in 126 low-risk to intermediate-risk patients (Toronto cohort) who will receive image-guided radiotherapy. We validated these indices in two independent cohorts of 154 (Memorial Sloan Kettering Cancer Center cohort [MSKCC] cohort) and 117 (Cambridge cohort) radical prostatectomy specimens from low-risk to high-risk patients. We applied unsupervised and supervised machine learning techniques to the copy-number profiles of 126 pre-image-guided radiotherapy diagnostic biopsies to develop prognostic signatures. Our primary endpoint was the development of a set of prognostic measures capable of stratifying patients for risk of biochemical relapse 5 years after primary treatment. FINDINGS Biochemical relapse was associated with indices of tumour hypoxia, genomic instability, and genomic subtypes based on multivariate analyses. We identified four genomic subtypes for prostate cancer, which had different 5-year biochemical relapse-free survival. Genomic instability is prognostic for relapse in both image-guided radiotherapy (multivariate analysis hazard ratio [HR] 4·5 [95% CI 2·1-9·8]; p=0·00013; area under the receiver operator curve [AUC] 0·70 [95% CI 0·65-0·76]) and radical prostatectomy (4·0 [1·6-9·7]; p=0·0024; AUC 0·57 [0·52-0·61]) patients with prostate cancer, and its effect is magnified by intratumoral hypoxia (3·8 [1·2-12]; p=0·019; AUC 0·67 [0·61-0·73]). A novel 100-loci DNA signature accurately classified treatment outcome in the MSKCC low-risk to intermediate-risk cohort (multivariate analysis HR 6·1 [95% CI 2·0-19]; p=0·0015; AUC 0·74 [95% CI 0·65-0·83]). In the independent MSKCC and Cambridge cohorts, this signature identified low-risk to high-risk patients who were most likely to fail treatment within 18 months (combined cohorts multivariate analysis HR 2·9 [95% CI 1·4-6·0]; p=0·0039; AUC 0·68 [95% CI 0·63-0·73]), and was better at predicting biochemical relapse than 23 previously published RNA signatures. INTERPRETATION This is the first study of cancer outcome to integrate DNA-based and microenvironment-based failure indices to predict patient outcome. Patients exhibiting these aggressive features after biopsy should be entered into treatment intensification trials. FUNDING Movember Foundation, Prostate Cancer Canada, Ontario Institute for Cancer Research, Canadian Institute for Health Research, NIHR Cambridge Biomedical Research Centre, The University of Cambridge, Cancer Research UK, Cambridge Cancer Charity, Prostate Cancer UK, Hutchison Whampoa Limited, Terry Fox Research Institute, Princess Margaret Cancer Centre Foundation, PMH-Radiation Medicine Program Academic Enrichment Fund, Motorcycle Ride for Dad (Durham), Canadian Cancer Society.

Hanns Ernst Jäger, Willy Trenk-Trebitsch, Szenenfoto, Doppelbildnis, in: Robert Penn Warren: Blut auf dem Mond, Deutsche Erstaufführung

Signatur des Originals: S 36/F11588