892 resultados para HCC ORT
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Bibliogr. Nachweis: Geschichtsblätter / Hogenberg, Nr. 372
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Bibliograph. Nachweis: Paas P-21
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... fleissig untersucht, kürtzlich beschrieben, nach dem Leben abgemahlt, ins Kupfer gestochen, und selbst verlegt, von Maria Sibylla Gräffinn, Matthaei Merians, des Eltern, seel. Tochter
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Signatur des Originals: S 36/F07040
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... fleissig untersucht, kürtzlich beschrieben, nach dem Leben abgemahlt, ins Kupfer gestochen, und selbst verlegt, von Maria Sibylla Gräffinn, Matthaei Merians, des Eltern, seel. Tochter
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[von Simon Schlimbach, Schullehrer]
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von C. Eichenlaub
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Sign.: [A]-B2, C8
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Cloning and sequencing of the upstream region of the gene of the CC chemokine HCC-1 led to the discovery of an adjacent gene coding for a CC chemokine that was named “HCC-2.” The two genes are separated by 12-kbp and reside in a head-to-tail orientation on chromosome 17. At variance with the genes for HCC-1 and other human CC chemokines, which have a three-exon-two-intron structure, the HCC-2 gene consists of four exons and three introns. Expression of HCC-2 and HCC-1 as studied by Northern analysis revealed, in addition to the regular, monocistronic mRNAs, a common, bicistronic transcript. In contrast to HCC-1, which is expressed constitutively in numerous human tissues, HCC-2 is expressed only in the gut and the liver. HCC-2 shares significant sequence homology with CKβ8 and the murine chemokines C10, CCF18/MRP-2, and macrophage inflammatory protein 1γ, which all contain six instead of four conserved cysteines. The two additional cysteines of HCC-2 form a third disulfide bond, which anchors the COOH-terminal domain to the core of the molecule. Highly purified recombinant HCC-2 was tested on neutrophils, eosinophils, monocytes, and lymphocytes and was found to exhibit marked functional similarities to macrophage inflammatory protein 1α. It is a potent chemoattractant and inducer of enzyme release in monocytes and a moderately active attractant for eosinophils. Desensitization studies indicate that HCC-2 acts mainly via CC chemokine receptor CCR1.
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Bibliography: p. [679]
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1. Teil. Das Kloster von seiner Gründung bis zu seinem Untergang.
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Cover-title.
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Includes bibliographical references.
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Mode of access: Internet.
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Mode of access: Internet.