Avaliação da atividade antiulcerogênica e tóxica dos estratos metanólicos e clorofórmico das folhas de Serjania erecta Radlk(Sapindaceae)

Pós-graduação em Biologia Geral e Aplicada - IBB

Avaliação dos mecanismos de ação antiulcerogênica e antidiarrêica dos extratos e partições obtidos a partir das folhas de Byrsonima intermedia A. Juss (Malphighiaceae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito dos extratos metanólicos das folhas de Davilla elliptica e Davilla nnitida na vigência de colite experimental induzida por ácido trinitrobenzenosulfônico em ratos

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Estudo químico e biológico de plantas da família Eriocaulaceae

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação do efeito protetor e cicatrizante do extrato hidroalcóolico de folhas de Solanum paniculatum L. frente á úlceras pépticas

Pós-graduação em Biologia Geral e Aplicada - IBB

Efeito do (-)-mentol sobre a úlcera gástrica: estudo do mecanismo gastroprotetor

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Determinação dos mecanismos de ação envolvidos no efeito antiulcerogênico, antidiarreico e anti-inflamatório da Insulina Vegetal (Cissus sicyoides Linneu) em modelos animais

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Avaliação dos mecanismos de ação envolvidos na atividade antiulcerogênica de Serjania marginata frente á doença ulcerosa péptica experimental

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Benzophenone guttiferone A from Garcinia achachairu Rusby (Clusiaceae) Presents Genotoxic Effects in Different Cells of Mice

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Healing Actions of Essential Oils from Citrus aurantium and d-Limonene in the Gastric Mucosa: The Roles of VEGF, PCNA, and COX-2 in Cell Proliferation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da atividade anti-inflamatória e antinociceptiva do extrato hidroalcoólico de Eugenia punicifolia (Kunth) DC

Inflammation is an immune complex-related tissue damage and / or cell caused by chemical, physical, immunological or microbial. The inflammatory process involves a complex cascade of biochemical and cellular events, including awareness and receptor activation, lysis and tissue repair. In general, tissue damage trigger a local inflammatory response by recruiting leukocytes, which release inflammatory mediators. These substances are able to sensitize nociceptors. After synaptic transmission and signal modulation by nociceptive sensory neurons, these signals are perceived as pain. Pain is an experience that involves multiple factors. The route of the supraspinal pain control originates in many brain regions, such as substance periarquedutal gray (PAG), median raphe nucleus and rostral ventromedial medulla (RVM) and have a critical role in determining the chronic and acute pain. Anti-inflammatory drugs (NSAIDs) are used to control inflammation, which inhibit the inflammatory mediators, but can cause side effects such as stomach ulcers and cardiovascular damage. An alternative for the treatment of pain and inflammation is the use of plant species. The genus Eugenia belongs to the family Myrtaceae, one of the largest botanical families of expression in the Brazilian ecosystems. From the pharmacological point of view, studies of similar species crude extracts showed the presence of anti-inflammatory, analgesic, antifungal, hypotensive, antidiabetic and antioxidant activity of some species. As a class of importance in therapeutic phytochemical, the flavonoids has represented an important group with significant anti-inflammatory and gastroprotective, and are present in a significant way in the chemical composition of genus Eugenia. The project´s overall objective is to evaluate the antinociceptive and anti-inflammatory activities from hydroalcoholic extract of leaves of Eugenia punicifolia (EHEP). In this work we performed acute toxicity ...

Avaliação do potencial efeito cicatrizante gástrico e antiartrítico da mangiferina, uma xantona glicosilada da Mangifera indica

Rheumatoid arthritis (RA) is a chronic illness with great potential to cause comorbidities resulting from cumulative inflammatory activities, and it contributes with the increase of disabilities and death of patients. It affects 1 to 2% of world population and usually occurs between 30 and 50 years of age. Among existing therapeutic options for the disease non-steroidal anti-inflammatory drugs (NSAIDs) still play an important part in the treatment, being widely used by patients to relieve pain and stiffness. However, this class of drugs causes many adverse gastrointestinal effects, such as dyspepsia, heartburn, nausea and vomit, and its use is one of the most common causes of peptic ulcers. Mangiferin (a glicosilated xanthone extracted mainly from the bark of Mangifera indica L.) is the main compound of an aqueous extract made from the bark stem of the mango tree. Previous studies conducted by our research group prove the anti-inflammatory action of mangiferin on an animal model of periodontitis, and its gastroprotective action has been described before. Considering these informations this study evaluated mangiferin’s potential on the treatment of RA and on gastric ulcer healing in animal models, and analyzed toxicity parameters to assure efficacy and safety of the compound as potential new drug for the treatment of the disease. RA was induced in rats by subcutaneous injection of bovine collagen and Freund’s complete adjuvant. This method presented low incidence of RA in rats, but we were able to induce the disease in 60 to 70% of the animals. Due to the wide use of NSAIDs and its potential to cause peptic ulcers, we induced gastric ulcer on arthritic rats to analyze mangiferin’s gastric healing effect. After 14 days of treatment we noticed small increase of the lesion area of animals treated with mangiferin or ibuprofen, when compared to the animals... (Complete abstract click electronic access below)

Avaliação de gastrocitoproteção, mecanismo de ação e comparação do efeito da vitamina E (α-Tocoferol) nas formas natural e sintética

The aim of this study was to verify if α-tocopherol, the main substance of Vitamin E and also the one with the major antioxidant propriety, could offer citoprotection to a stomach damaged by alcohol. There are many forms of α-tocopherol, two forms of them were evaluated; d-l-α-tocopherol, the synthetic form and d-α-tocopherol, the natural form of α-tocopherol. Three experiments were made, all of them having absolute ethanol as the lesion agent, but the period and the doses changed in each of them. In the first two experiments, each group of animals received a different form of α-tocopherol and in the third experiment, they’ve received α-tocopherol p.o. for the period of seven days before the lesion agent was administrated. Moreover, immunohistochemistry assays were made from the stomachs samples of the third experiment to verify possible mechanisms involving nitric oxide and 2-cyclooxygenase. Satisfactory results of citoprotection have been obtained when the two forms were administered in the period of one week at doses of 100 mg/kg for synthetic form and 150 mg/kg for natural type. Nevertheless, the two forms didn’t differ statistically in their effectiveness against ethanol. The immunohistochemistry assays showed an increase of the levels of NO and COX2 in relation with the negative control, although there was no correlation between this increase and the gastroprotective effect. In conclusion, α-tocopherol has gastroprotection effect in some doses, but apparently there is no such a thing like the better the dose, the better the effect; that citoprotection don’t have a relationship with NO neither with COX2; the natural and the synthetic form don’t differ in their gastroprotection effect. More studies must be done looking forward an effective dose and also to understand the mechanisms underlay the citoprotection of α-tocopherol in the stomach