Determinação de genes potencialmente responsivos à radiação ionizante através de aprendizado de máquina

A predição da resposta do tumor a radioterapia e a questão mais importante durante o tratamento de pacientes com câncer. Como consequência, a predição de genes que sejam responsivos a radiação ionizante e uma possibilidade para a melhoria dos resultados clínicos e a otimização das doses as quais os pacientes são submetidos ao longo do tratamento. Juntamente com esses dados, é possível obter respostas sobre os mecanismos de resistência a radiação dos tumores e até mesmo a identificação de biomarcadores responsáveis pela resistência a radiação ionizante que podem ser potenciais para o desenvolvimento de novas drogas visando a proteção de tecidos saudáveis. A determinação experimental dos genes que sejam responsivos à radiação ionizante é algo caro e que demanda muito tempo e trabalho; porém, se utilizarmos uma forma computacional de direcionar os estudos experimentais diretamente aos genes que têm mais potencial para serem responsivos à radiação ionizante, as pesquisas podem ser mais direcionadas e específicas. Para determinar essa característica, construímos, analisamos e determinamos os dados da topologia da rede integrada de interações moleculares entre genes humanos, contendo interações físicas entre proteínas, interações metabólicas e interações de regulação transcricional. Os dados topológicos foram utilizados como atributos de treinamento para o aprendizado de máquina, no qual os genes conhecidamente responsivos à radiação ionizante foram apresentados a um algoritmo de árvore de decisão que gerou modelos de predição com índices de sensibilidade e precisão de 5% e 72%, respectivamente. Os índices de acerto obtidos para os conjuntos de teste foram satisfatórios, retornando 91% dos genes conhecidos como responsiveis à radiação ionizante utilizados para o treinamento da árvore de decisão. Nós aplicamos o modelo de predição na rede integrada e atribuímos probabilidades ...

Terapia fotodinâmica - Aplicações em lesões cutâneas

Photodynamic therapy is a method of healing skin lesions , in addition to radiotherapy and brachytherapy are commonly used in the treatment of skin cancers , but it is still little known in Brazil , consisting of the application to the skin of a drug in the form of cream or lotion ( photosensitizer ) . It is absorbed by tumor cells and subsequently activated by light device , that wavelength of light in the order of 630 nanometers , promoting the selective destruction of cancer cells while preserving healthy cells around the lesion . It can be considered highly effective for treatment of skin cancer types of non-melanoma ( basal cell carcinoma , 85-100 % success in curing [ 3 ] , and Bowen's disease), actinic keratoses , which are precancerous lesions and still no studies that prove also action in the treatment of acne and aging caused by the sun . And the advantage of this treatment is that , when indicated , replace the surgical procedure , selectively treating the diseased cells . Thus, it offers better cosmetic results, reducing the risk of scarring [ 4 ]

A crítica de Mandelbrot: normalidade como exceção e não como regra

Starting with a brief introduction about the evolution of asset pricing models, we seek here to introduce the critique made by Benoit Mandelbrot about using the normality hypothesis when building such models. This critique arises when empirical and theoretical models where confronted and the expected results diverged from the ones obtained. Next, we reproduce Mandelbrot alternative which he believes is sufficient to solve the main problems implied by the normality hyphotesis

Gestão de estoque em uma empresa de varejo de produtos de limpeza e higiene pessoal

The deficiency in the product inventory management is common in small businesses, affecting several areas, especially the purchasing department that has difficulty in performing their tasks, acquiring the supplier's products at the time and in the most appropriate amount. Especially in the retail sector, the loss of quality of services is visible, because the availability of the product when there is demand is essential for the occurrence of sales and customer satisfaction. In this study, looking to improve inventory management in a retail company of cleaning products and personal hygiene, apply the classification method ABC (or Pareto Rule) to segment the available products. Thus are adopted buying criteria of new products based on the concepts of economic order quantity, safety stock and resupply point. The results show the feasibility of this procedure adopted because it was possible to propose an improved inventory management in a simple and effective way, contributing to company's competitive advantage

Aplicação do AHP em um caso de escolha dos modais de transporte para a movimentação das partes de um aerogerador

Wind power is a type of energy that is still not too explored in Brazil and, because of the lack of experience in projects of this size, there are still some problems during the stages of planning and execution of wind farms projects. One of these problems is related with the parts’ transportation logistics, since these parts are difficult to transport, because of their length, weight or shape. Furthermore, another aggravating factor is the lack of options regarding to the transportation modals that are available to do the route between the manufacture place and the project site. To help in the decision-making process about the ideal transportation configuration, aiming to reduce the dependence of the logistics’ coordinator, it was chosen to use he AHP method to compare some criteria that have influence in the modal’s choice process. The criteria, determined by the members of the company’s logistics’ department, are: transportation costs, transportation time and the risk of causing damages to the cargo. The results shown by this model, using theoretical background, that standardize the processes related to the modal’s choice

Reestruturação recente da indústria petroquímica: análise Brasil-Mundo do processo de integração vertical

Este estudo analisa o desenvolvimento do processo de integração vertical na indústria petroquímica brasileira a partir da década de 90, focando nos determinantes para este movimento e confrontando com o mesmo processo adotado em grandes empresas mundiais da indústria

A posição do sujeito em diferentes gêneros textuais do jornal O Araraquarense: um estudo variacionista

Este trabalho objetiva estudar o fenômeno da posposição do sujeito com relação ao verbo em distintos tipos e gêneros do jornal: O Araraquarense do início do século XX, e verificar se há alguma diferença entre eles, quanto à posição do sujeito na frase. A escolha de um corpus jornalístico é devida ao fato de seu texto ser muito propício para analisar os processos de implementação de uma possível mudança no português brasileiro; por se tratar de um texto público, o qual atua sobre os elementos da situação sócio-histórica em que está inserido e por sofrer influências dessa situação. Foram analisados dados coletados de artigos de opinião e notas sociais, levando em conta os tipos textuais: descrição, dissertação, injunção e narração (TRAVAGLIA, 2003, p.103). Constatou-se que os tipos (dissertativo e narrativo) foram predominantes nos artigos de opinião, e que somente o tipo narrativo esteve presente nas notas sociais. A posição do sujeito foi analisada em função dos seguintes grupos de fatores: tipo sintático do verbo, tipo morfológico do sujeito, padrão de construção e tipo textual. Como principais resultados, constatou-se: (i) um índice de posposição de 47% em notas sociais e de 19,2% em artigos de opinião; (ii) tipo do verbo (transitivo direto) 21,7% em artigos de opinião e 44,7% em notas sociais; neste mesmo gênero os verbos (inacusativo, bitransitivo, intransitivo e verbo de ligação) apresentaram, respectivamente, 71%, 45%, 37% e 37,9%; (iii) tipo morfológico do sujeito (sintagma nominal) em artigo de opinião 16,5% e 41,4% em notas sociais, 28,2% de (pronome pessoal) em artigo de opinião e 68,3% de (nome próprio) em notas sociais; (iiii) tipo textual (narrativo) 47,6% em notas sociais e em artigo de opinião 18,8% (dissertativo) e 27,8% (injuntivo)

O conflito ideológico no discurso sobre a maconha: uma abordagem dialógica de matérias impressas veiculadas na mídia brasileira

According to data published on the World Drug Report 2012 by Unodc - United Nations Office on Drugs and Crime -, the world consumes nowadays the same amount of illicit drugs that it has always consumed. Contrary to this stable consumption, discussions surrounding the issue of drugs have intensified. The greatest controversies and the largest repercussion in the Brazilian media relate to marijuana use. This paper was developed in the context of polemic issues and its general goal is to analyze the conflict of ideologies present in the discourses about drugs on printed articles released by the Brazilian media, represented here by the magazines Veja, Carta Capital and Galileu. This study is carried out based on a dialogic approach, supported by the Bakhtinian researches on discourse

Estudo sobre eficiência energética em uma indústria de injeção plástica

The reason of this work is perform a study about using of electrical energy to identify the opportunities through rational use of electrical energy. For that it was necessary perform an analysis of hired energy against consumption. Based in a guide of energy analysis were found the main consumers and verified the main problems, which generate excessive use of electrical energy in a plastic injection factory. It was also analyzed the painting line because there are some thermal equipment that use electrical energy. Based on the data obtained will be proposed ways to reduce the needless consumption and energy use of rationally and efficiently, in addition to re-evaluate the contracted demand based on the new policy of supplying and charging.It were also proposed thermodynamics solutions to reduce the energy consumed in thermal process

Evolucionismo linguístico: um paralelo entre evolucionismo biológico e mudança linguística

The comparison between linguistic change and biologic evolution is a subject that has caused and still causes much controversy among linguists and other academics that see, in this parallel, problems related to similar attempts in the nineteenth century by Social Darwinism, which approached the biological evolution with social and cultural development of a people. However, this paper aims to show that today this parallel is not built in the same way as was done before. Names like William Labov, Salikoko Mufwene, Jonathan West and Hildo Honorio do Couto in linguistics; Charles Darwin in biology; and Tom Ingold and Clifford Geertz in anthropology, showed that areas of Humanities, such as linguistics and anthropology, and of Biological Sciences, as phylogeny and genetics, are likely to be worked together by the great similarities between processes that compose them. Thus, based on the writings of these authors and some others, this paper presents this theme’s controversy; it shows the similarities between characteristics of languages and species; it seeks through the concepts MA Mental, MA Social and MA Natural of the languages (coined by Couto on Linguística, ecologia e ecolinguística: contato de línguas) to develop ideas of how it is possible to think the language change in the light of Darwin's concept, Natural Selection; and finally, it shows that the parallel theme is rather productive, based on the texts and discussions presented in the whole paper, and that the controversy has been being dissolved with more and more people working on the parallel between language and species

Gestão da Manutenção Centrada na Confiabilidade em Pontes Rolantes

The objective of this work is to perform a study applying the methodology of Reliability Centered Maintenance - MCC to a group of cranes belonging to Amsted -Maxion in Cruzeiro - SP. The work consists of a presentation of maintenance, the reasons why more and more people worry about maintenance, making a presentation on the types of maintenance, its peculiar characteristics and then do a study where you identified the functionality required by the equipment under study, identified failure modes and their probable causes, and then detail the effects and consequences of these failures. With that evaluate the criticality of these failures and identify the most significant consequences that affect safety, availability or cost of equipment operation and allow a selection of the most appropriate tasks for the identified failure modes. We will also present best crane equipment, its main components, verify that there was or not improvement in the machine after the application of MCC and make a current analysis of maintenance in Amsted -Maxion

O processo de compreensão de texto de ficção científica na década de 30: Admirável Mundo Novo à luz da teoria semiótica

This paper is result of an analysis of the Brave New World by Aldous Huxley, made based on the perspective of discursive semiotics. For both, the elements of the generative course of meaning were applied, particularly those in works of Barros (2001) and Fiorin (2000). In view of that each of the three levels (elementary, narrative and discourse) of semiotics approach are considered capable of independent descriptions, we sought through the (re) construction of meaning of specific parts of the work and also the relationship of its thematic route with the time it was composed, found that, as a result of this work, the relationships between fiction and reality and thus the relevance of the work of Aldous Huxley

Poética e Figuratividade: uma análise de Io (Ovídio, Metamorfoses, I, 583-747)

This paper presents the development of a scientific investigation that addresses the Latin text using theoretical concepts of Linguistic, Literary Poetic and Semiotic in order to focus mainly on aspects of the figurative expression. Therefore, the meaning effects raised by the perception through the reading of text were taken as baseline data to investigate the particular arrangement of language, responsible for expression of these effects. As a result of this investigation, a metalinguistic discourse was produced about the basic features of the poetic figurativity of the text. This analysis and description had a focus mainly on the first step of the procedures of figurativization, i.e., the figuration of the discourse, when a theme is coated by semiotic figures. In addition, reference notes were drafted to accompany the selected translation of support, with general comments about the culture (mythology, history, geography, philosophy, etc.), necessary data to an more comprehensive understanding of the text (these notes shall provide basic subsidies for reading the original Latin)

Análise da implementação do balanced scorecard em uma fornecedora de tecnologia da informação

Many companies have invested substantial resources in recent years in implementing the Balanced Scorecard, a strategic management tool that embraces not only financial perspectives, but also three other perspectives that create an overall and long-term vision of the company. The purpose of this article is to analyze, through interviews and action research, the implementation of the Balanced Scorecard in a provider of information technology and suitability for the company area Alliances and Channels, identifying determinants factors that exist in the literature and contributing to a greater understanding around this strategic management tool. The study shows that the implementation of the company was not successful, but the area of Alliances and Channels suit tool in order to find good results and two new determinants, other than those existing in the literature, were found

A presença das TIC no curso de licenciatura em matemática da UNESP - campus Guaratinguetá

This research shows an investigation on teaching formation in regards to the TICs. Our interest in this subject is due to the fact that new generations of students who attend school require that the classes make use of technology in the classroom environment. By following the phenomenological orientation we have carried out a study which involved a field research at the College of Engineering in Guaratinguetá using the graduate as well as senior students of the Bachelor's Degree in Mathematics of this university. We have analyzed the data under the light of texts of the following authors: Filho (2007), Valente (1993), Miskulin (2006), Borba and Penteado (2001) among others in order to understand the teacher`s formation process to act using technologies in the classroom and its relevance. The data that has been analyzed was obtained in interviews which were conducted with the students of this university. The interviews were transcribed and analyzed according to the rigor of phenomenological research procedures involving ideographic and nomothetic analysis. This analysis has led us to three open categories: 1) Mathematics learning through TICs; 2) Technologies that have been used; 3) Teacher`s role. By understanding the open categories we have been able to grasp that the students -future teachers- admit feeling capable of using technology in their classes, however their testimonies in regards to the TIC`s have led us to believe that there would be a reproduction of the content studied at their time at college without using further reflection upon the subject or autonomy in order to create new projects for teaching Mathmatics using these TICs