La difesa de' libri Santi e della religione giudaica,

Translation of Défense des livres de l'Ancien testament.

Diario sacro; [o sia,Notizie de' santi martiri dell'alma città di Roma,e de' loro più venerandi monumenti].

Mode of access: Internet.

Notizie istoriche de' santi protettori della città d'Ancona; de' cittadini, che con la loro santità l'anno illustrata, della di lei cattedrale, e vescovi, della città, e SS. crocefisso d'Umana. Date alla luce per maggiormente promovere la pubblica divozione.

Mode of access: Internet.

Avellino illustrato da' santi e da' santuari /

Includes indexes.

Dictamen sobre la Inmaculada Concepción de María Santísima, 14 de agosto de 1849.

Cover-title: Consulta del M.I.y V. Cabildo eclesiastico de Guadalajara, al illmo. señor obispo de esta diocesis, relativa al asunto de que habla la Enciclica de ... Pio IX, dada en Gaeta á 2 de Febrero de 1849. Y razon de lo que han contestado sobre lo mismo los sres. curas, cumunidades religiosas &.

Breve racconto sopra il discoprimento delle sagre immagini de' santi Sebastiano e Rocco, comprotettori dell' illustrissima città di Frascati seguito nella chiesa di S. Maria del Vivario, ovvero il Duomo Vecchio alli 18. di giugno 1656.

Mode of access: Internet.

EURICO ALFREDO NELSON (1862-1939) E A INSERÇÃO DOS BATISTAS EM BELÉM DO PARÁ

Esta dissertação propõe-se apresentar alguns aspectos que favoreceram a chegada do cristianismo batista em Belém do Pará, nos idos do século XIX e XX. Além disso, se fará uma descrição da urbe, apontando alguns fatores que possibilitaram a imigração de Eurico Nelson. Trata-se de um sueco batista que veio viver pela fé numa cidade visivelmente adensada pelo processo de exploração da borracha e que permitia em seu cenário a movimentação de várias pessoas de diferentes nacionalidades, além do próprio homem procedente da Amazônia, que guarda forte herança indígena. Far-se-á um recorte dos seis primeiros anos da atuação de Eurico Nelson na cidade, analisando suas atividades religiosas nesse contexto cultural tão diferente do seu, como ponto de partida para entender as tessituras do cotidiano batista emergente no Pará. Ou seja, há uma suspeita de que os batistas de Belém do Pará, na história da implantação desta igreja, possuem características pouco contempladas por sua historiografia tradicional, que provavelmente decorrem da dinâmica de inserção neste contexto urbano específico.

Domestic violence (DV) service provision and the architecture of rural life: An Australian case study

This article uses the concept of the architecture of rural life to analyse domestic violence service provision in rural Australia. What is distinctive about this architecture is that it polices the privacy of the rural family. A tight cloak of silence is carved around instances of domestic violence. Imagined threats to rural safety are seen as coming from outsiders (i.e. urban influences or Indigenous), not insiders within rural families. This article draws on key findings from a study conducted in rural New South Wales, Australia. The study interviewed 49 rural service providers working in human services and the criminal justice system. The application of architecture of rural life as a conceptual tool demonstrates challenges with service provision in a rural setting. The main results of this study found that this architecture operates as a silencing form of social control in three distinctive ways. Firstly, shame about being a victim of domestic violence encourages rural women's complicity in remaining silent. Secondly, family privacy maintains a veil of silence that accentuates rural women's social and economic dependency on men. Thirdly, community sanctions act as a deterrent to women seeking help.

Covalent tethering of the dimer interface annuls aggregation in thymidylate synthase

Thymidylate synthase (TS), a dimeric enzyme, forms large soluble aggregates at concentrations of urea (3.3-5 M), well below that required for complete denaturation, as established by fluorescence and size-exclusion chromatography. In contrast to the wild-type enzyme, an engineered mutant of TS (T155C/E188C/C244T), TSMox, in which two subunits are crosslinked by disulfide bridges between residues 155-188' and 188-155', does not show this behavior. Aggregation behavior is restored upon disulfide bond reduction in the mutant protein, indicating the involvement of interface segments in forming soluble associated species. Intermolecular disulfide crosslinking has been used as a probe to investigate the formation of larger non-native aggregates. The studies argue for the formation of large multimeric species via a sticky patch of polypeptide from the dimer interface region that becomes exposed on partial unfolding. Covalent reinforcement of relatively fragile protein-protein interfaces may be a useful strategy in minimizing aggregation of non-native structures in multimeric proteins.

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN.

Effect of amino acid substitutions at the subunit interface on the stabiity and aggregation properties of a dimeric protein: role of Arg 178 and Arg 218 at the dimer interface of thymidylate synthase

The significance of two interface arginine residues on the structural integrity of an obligatory dimeric enzyme thymidylate synthase (TS) from Lactobacillus casei was investigated by thermal and chemical denaturation. While the R178F mutant showed apparent stability to thermal denaturation by its decreased tendency to aggregate, the Tm of the R218K mutant was lowered by 5 degrees C. Equilibrium denaturation studies in guanidinium chloride (GdmCl) and urea indicate that in both the mutants, replacement of Arg residues results in more labile quaternary and tertiary interactions. Circular dichroism studies in aqueous buffer suggest that the protein interior in R218K may be less well-packed as compared to the wild type protein. The results emphasize that quaternary interactions may influence the stability of the tertiary fold of TS. The amino acid replacements also lead to notable alteration in the ability of the unfolding intermediate of TS to aggregate. The aggregated state of partially unfolded intermediate in the R178F mutant is stable over a narrower range of denaturant concentrations. In contrast, there is an exaggerated tendency on the part of R218K to aggregate in intermediate concentrations of the denaturant. The 3 A crystal structure of the R178F mutant reveals no major structural change as a consequence of amino acid substitution. The results may be rationalized in terms of mutational effects on both the folded and unfolded state of the protein. Site specific amino acid substitutions are useful in identifying specific regions of TS involved in association of non-native protein structures.

Modelling multiple disulphide loop containing polypeptides by random conformation generation. The test cases of α-conotoxin GI and edothelin I

A general procedure for arriving at 3-D models of disulphiderich olypeptide systems based on the covalent cross-link constraints has been developed. The procedure, which has been coded as a computer program, RANMOD, assigns a large number of random, permitted backbone conformations to the polypeptide and identifies stereochemically acceptable structures as plausible models based on strainless disulphide bridge modelling. Disulphide bond modelling is performed using the procedure MODIP developed earlier, in connection with the choice of suitable sites where disulphide bonds could be engineered in proteins (Sowdhamini,R., Srinivasan,N., Shoichet,B., Santi,D.V., Ramakrishnan,C. and Balaram,P. (1989) Protein Engng, 3, 95-103). The method RANMOD has been tested on small disulphide loops and the structures compared against preferred backbone conformations derived from an analysis of putative disulphide subdatabase and model calculations. RANMOD has been applied to disulphiderich peptides and found to give rise to several stereochemically acceptable structures. The results obtained on the modelling of two test cases, a-conotoxin GI and endothelin I, are presented. Available NMR data suggest that such small systems exhibit conformational heterogeneity in solution. Hence, this approach for obtaining several distinct models is particularly attractive for the study of conformational excursions.