Chemical composition, age, and magnetic parameters of igneous rocks from the Franz Josef Land

A combined study of magnetic parameters of basalt and andesite samples has been carried out in the framework of geological investigations of the Franz Josef Land. This study has included determination of coercivity, saturation magnetization, Curie points, natural remanent magnetization (NRM), and magnetic susceptibility as well as examination of ferromagnetic minerals with a microscope. Data on chemical composition of the rocks have been obtained for all the samples, and radiological ages have been determined for the majority of the rocks. Thermomagnetic curves of the samples have been subdivided into four types depending on composition of ferromagnetic NRM carriers. Data showing multiple changes in the predominant composition of the igneous rocks have been obtained. Each stage of magmatism is characterized by a specific type of the ferromagnetic component in the rocks and, therefore, magnetomineralogical investigations can be used for differentiation and correlation of the igneous rocks.

Copia del codicil, 1669 jul. 20 de Fran[se]ch Oller Pagés de la Parróquia de S[an]t Iscla [i. e. Iscle] y Victoria de Vallalta [Manuscrito]

Alcance y contenido: Copia ms. de las claúsulas testamentarias que se añaden en 1669, al testamento de Francisco Oller Pagés, parroquiano de S. Iscle de Vallalta (obispado de Gerona), que en principio se redactó y firmó en 1665, constituyendo como marmesor a Jacinto March presbitero y vicario de dicha parroquia, legando 260 libras para el descanso de su alma y otras cantidades a su mujer y sus dos hermanas.

Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκB�� and IκB�� degradation

As previously reported, Listeria monocytogenes infection of P388D1 macrophages results in a rapid induction of NF-κB DNA-binding activity. Here we show that this induction of NF-κB activity occurs in a biphasic mode: first, a transient, IκB�� degradation-dependent phase of activity, also induced by the nonvirulent species Listeria innocua, which is mediated by binding of the bacteria to the macrophage, or by adding Listeria-derived lipoteichoic acid to the macrophage; the second persistent phase of activation is only markedly induced when the bacteria enter the cytoplasm of the host cell and express the virulence genes plcA and plcB, encoding two phospholipases. We suggest that products of the enzymatic activity of phospholipases directly interfere with host cell signal transduction pathways, thus leading to persistent NF-κB activation via persistent IκB�� degradation.

The Interaction and Colocalization of Sam68 with the Splicing-associated Factor YT521-B in Nuclear Dots Is Regulated by the Src Family Kinase p59fyn

Alternative pre-mRNA splicing patterns can change an extracellular stimulus, but the signaling pathways leading to these changes are still poorly characterized. Here, we describe a tyrosine-phosphorylated nuclear protein, YT521-B, and show that it interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. Northern blot analysis demonstrated ubiquitous expression, but detailed RNA in situ analysis revealed cell type specificity in the brain. YT521-B protein is localized in the nucleoplasm and concentrated in 5–20 large nuclear dots. Deletion analysis demonstrated that the formation of these dots depends on the presence of the amino-terminal glutamic acid-rich domain and the carboxyl-terminal glutamic acid/arginine-rich region. We show that the latter comprises an important protein–protein interaction domain. The Src family kinase p59fyn-mediated tyrosine phosphorylation of Sam68 negatively regulates its association with YT521-B, and overexpression of p59fyn dissolves nuclear dots containing YT521-B. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. Together, our data indicate that YT521-B and Sam68 may be part of a signal transduction pathway that influences splice site selection.

The transcriptional program of a human B cell line in response to Myc

The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of downstream genes. Here we report the identification of potential Myc target genes in a human B cell line that grows and proliferates depending on conditional myc expression. Oligonucleotide microarrays were applied to identify downstream genes of Myc at the level of cytoplasmic mRNA. In addition, we identified potential Myc target genes in nuclear run-on experiments by changes in their transcription rate. The identified genes belong to gene classes whose products are involved in amino acid/protein synthesis, lipid metabolism, protein turnover/folding, nucleotide/DNA synthesis, transport, nucleolus function/RNA binding, transcription and splicing, oxidative stress and signal transduction. The identified targets support our current view that myc acts as a master gene for growth control and increases transcription of a large variety of genes.

Beschreibung der groszen Orgel der Marienkirche zu Wismar sowie der groszen Orgel des Domes und der St. Martinikirche zu Halberstadt : ein Beitrag zur Beleuchtung und Würdigung der eigenthümlichen Ansichten und Grundsätze des Herrn Musikdirectors Wilke zu Neu-Ruppin in Bezug auf die Orgelbaukunst von Ferdinand Baake.

Contains history and description of organs built by Friedrich Schulze, David Beck, Josef Wiedemann, and Johann Gottlob Töpfer.

Aḥmad b. aṭ-Tayyib as-Saraḫsî,

Includes "Unpublished texts" (p. 127-135) in Arabic characters.

Rondo in B dur für Pianoforte, 2 Violinen, Flöte, 2 Klarinetten in B, 2 Hörner in B, Viola, Violoncello und Bass, op. 9 /

Mode of access: Internet.

Concerto in D [i.e. B minor] : for four solo violins, with accompaniment of string instruments (violas, cello and bass) and piano (cembalo) [op. 3, no. 10] /

Mode of access: Internet.

Traités mystiques d'Abou Alî al-Hosain b. Abdallah b. Sênâ ou d'Avicenne.

Added t.p. in Arabic.