Obtenção de forma farmacêutica sólida de extrato etanólico de Casearia sylvestris Swartz

A espécie vegetal Casearia sylvestris é uma planta nativa do Brasil e de uso tradicional, sendo utilizada popularmente para combate de doenças do trato digestório. Seus extratos e mesmo substâncias purificadas apresentaram diversas atividades farmacológicas, sendo a mais eficaz a ação antiulcerogênica. Neste trabalho, desenvolveram-se granulados a partir do extrato etanólico de folhas de C. sylvestris. A metodologia envolve métodos de extração de droga vegetais, granulação via úmida e ensaios de caracterização do perfil micromerítico dos granulados

Avaliação da permeação cutânea do acetato de dexametasona incorporado em sistemas nanoestruturados

O acetato de dexametasona (DXM) é um glicocorticoide com eficácia antiinflamatória e imunossupressora, sendo utilizado nas doenças autoimunes. Sua ação antiinflamatória advém da inibição do acúmulo de células (macrófagos, linfócitos e neutrófilos) na área da inflamação, inibindo também a liberação de mediadores da inflamação como interferon-γ e TNF-α. Já a atividade imunossupressora é alcançada com a redução do concentrado de linfócitos e inibição da síntese e/ou liberação de interleucinas. Porém o uso contínuo do DXM ocasiona uma série de efeitos colaterais sistêmicos, sendo interessante sua aplicação tópica para viabilizar a promoção do aumento da liberação e a estabilização dos níveis plasmáticos do fármaco. Sistemas nanoestruturados como microemulsões (ME) e os cristais líquidos (CL) vêm sendo estudados como novos sistemas de liberação, pois além de se comportarem como reservatórios de fármacos também possibilitam o aumento da estabilidade e da solubilidade dos princípios ativos. Os objetivos deste trabalho foram desenvolver e caracterizar sistemas micro e nanoestruturados, com intuito de incorporar DXM e avaliar sua permeação cutânea in vitro. Foram desenvolvidos sistemas utilizando água, silicone (DC® 193C fluido) e polioxietileno-20-oleil éter (Brij® 98). Os 36 pontos do diagrama de fases foram avaliados, sendo elaboradas formulações com diferentes proporções de água, óleo e tensoativo, sendo possível delimitar regiões como: sistemas transparentes de alta viscosidade (STAV), sistemas transparentes de baixa viscosidade (STBV), sistemas líquido-transparentes (SLT), emulsão viscosa (EV) e emulsão líquida (EL). Três formulações foram selecionadas para os ensaios de caracterização, fixando-se a concentração de tensoativo (T) em 40% e variando-se as concentrações de água e de silicone, denominadas A, B e C. As análises de microscopia de luz polarizada ...

Incorporação do trans-resveratrol em sistemas nanoestruturados: avaliação das ações antioxidante e despigmentante in vitro

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise do desempenho físico-mecânico de painéis compensados de Pinus sp. produzidos com adesivos aquosos a base de poliacetato de vinila e de homopolímero vinílico

This study aimed to evaluate the physico-mechanical performance of three PVA adhesive formulations according to the Brazilian standards for plywood testing and to evaluate the results with those presented in the technical literature and specified in normative documents. The study presents the production process of the panels, the obtaining of samples and, finally, the implementation of physico-mechanical characterization tests based on plywood Brazilian standards. For the panels production it was used a gramature of 120 g / m² and applied a pressure of 15 bars and two temperature combinations and pressing time for each adhesive. The commercial adhesives used were PVA 1810, PVA 1060 and Vinyltec 239. The physical tests conducted were thickness swelling, density, moisture content and water absorption. The mechanical tests were static flexion, for the determination of elasticity modulus (MOE) and rupture modulus (MOR), and shear in the glue line. Among the three formulations studied none showed good performance in the presence of water. However, other trials in the adhesive showed better results and closer to the commercially equivalent used, in the case the urea-formaldehyde, was the PVA 1810, that can be applied in non-structural uses and in environments without the presence of moisture

Análise da influência do agente umectante na estabilidade reológica e avaliação de cristais líquidos em formulações cosméticas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Reaproveitamento de lamas residuais do processo de fabricação do concreto.

Nos dias atuais, um dos maiores problemas de uma central dosadora de concreto são as sobras de resíduos de concretos que retornam nos caminhões, das obras gerando lamas decantadas com pH elevado caracterizando-a como resíduo perigoso e representando gastos elevados com destinação. O objetivo do presente trabalho visa estudar em detalhes a composição da lama residual do processo de fabricação do concreto excluindo o agregado graúdo, verificando qual é a influência de sua adição no concreto. Com isso, pretende-se estudar algumas formas de tratamento e viabilizar economicamente o seu reaproveitamento em substituição ao agregado miúdo. Para esse estudo foram coletadas duas amostras desse material cimentício, sendo uma coletada diretamente do tanque de decantação e a segunda coletada da própria lavagem dos caminhões betoneiras. Elas foram submetidas a ensaios de caracterização como: análise termogravimétrica (TG), granulometria a laser e calorimetria e ensaios de concreto fresco (reologia e abatimento) e concreto endurecido. Para a viabilização econômica foi realizado um estudo de caso em três centrais dosadoras de concreto, afim de identificar perdas de materiais, custos de destinação e custo variável na fabricação de concreto. Os resultados mostraram que a forma de coleta do material cimentício influencia na finura do material conforme ensaio de granulometria e densidade aparente, mas não foi possível obter cimento anidro. A possibilidade de utilização da lama em concretos foi possível com ajuda de aditivos superplastificantes, mas para a viabilização economicamente viável a cadeia produtiva do concreto estudou-se um teor ótimo de substituição da lama pelo agregado miúdo.

Degradação anaeróbia de fenol sob diferentes condições nutricionais

A tecnologia anaeróbia tem sido utilizada com sucesso no tratamento de água residuária contendo compostos fenólicos. Recentes pesquisas incluem tais compostos entre aqueles que podem ser degradados através desse processo. O objetivo desse trabalho foi avaliar a degradação do fenol em diferentes condições nutricionais, com ênfase na redução do sulfato. Os experimentos foram realizados com meio de cultura específico para esses microrganismos anaeróbios. Foram realizados ensaios de degradação em reatores em batelada alimentados nas seguintes condições: (1) fenol e sulfato, a diferentes concentrações, com inóculo previamente enriquecido; (2) fenol, sulfato e co-substratos e; (3) fenol, sulfato e extrato de levedura. Todos os ensaios foram realizados em temperatura de 30 graus Celsius, sob agitação de 150 rpm. Foi avaliado o consumo de fenol e sulfato e, produção de metano, em função do tempo, para diferentes concentrações iniciais de fenol e sulfato. Nos ensaios com reatores alimentados com fenol (329,3 mg/l); fenol (307,3 mg/l) e sulfato (160 mg/l); fenol (322.3 mg/l), sulfato (160 mg/l) e lactato (478,16 mg/l); fenol (332,1 mg/l), sulfato (150 mg/l) e etanol (129,76 mg/l), a remoção foi de, respectivamente, 99,8%, 98,2%, 98,8% e 98,8%. Os reatores alimentados com fenol (239,7 mg/l) obtiveram 100% de eficiência na degradação em apenas 11 dias e, os reatores alimentados com fenol (234,3 mg/l) e sulfato (162,5 mg/l) e fenol (256,0 mg/l) e sulfato (500 mg/l) tiveram eficiências de degradação de, respectivamente, 98,8% e 99,3% com 17 dias de operação. Tais eficiências foram obtidas pelo acréscimo de extrato de levedura nos reatores, no início dos ensaios. A caracterização morfológica foi realizada através de microscopia óptica. A diversidade microbiana referente aos Domínios Bacteria e Archaea, além do grupo de bactérias redutoras de sulfato foi avaliada através da técnica de PCR DGGE, onde foram observadas alterações nas populações microbianas, em função das condições nutricionais. Para o Domínio Archaea não foram observadas diferenças nos ensaios realizados. Para o Domínio Bacteria e Grupo das BRS essas diferenças foram, mais facilmente, percebidas com relação ao inóculo e entre os diversos reatores. A alteração na diversidade microbiana pode ter sido decorrente da composição do meio que, nesse caso, foi específico para BRS e a composição do inóculo que continha parte previamente adaptada às BRS. Essas condições adequadas puderam propiciar surgimento e desenvolvimento de populações microbianas capazes de degradar fenol, utilizando sulfato.

Análise de estabilidade de falésias na zona costeira de Baía Formosa - RN

The natural and anthropogenic changes that are occurring at the coastal zone around the world represent the greatest problem to society in this century. This problem becomes more evident due to high density of coastal cities, to growing tourist-estate speculation of those areas and to climate change that tend to trigger and accelerate the erosive processes that operating in the littoral. In this context, it‟s possible perceive ever more a significant increase of problems associated to the coastal erosion and retreat of cliffs in the state of Rio Grande do Norte, where this study area of this search is located. The area is located in the coastal zone of the city of Baía Formosa/RN, in south-eastern coast of Rio Grande do Norte, and has a extension of about 1200 meters along the Porto beach. The main objective of this study is to analyze the stability of these cliffs in this region. Through field investigations, testings and computational analysis using the Finite Element Method and Equilibrium Limit Methods. The area was divided into four sections, and were applied checklists, and also realized characterization tests and direct shear tests with materials obtained along these sections. In this manner, it was found that the segments of cliff in this coastal zone have heights around 4 meters to 14 meters and inclinations of approximately 40° to 90°.However the constituents soils of the cliffs were classified, in general terms in accordance to Unified Soil Classification System (USCS), as clayey sands or silty sands, clays of low plasticity, clayey gravels and poorly graduaded sands. The most variegated and clayey soils belong to base of the cliff. The stability analysis showed that the safety factors ranged in section 01, from 1.92 to 4.93, in the section 02, from 1.00 to 1.43, in the section 03, from 1.36 to 1.75 , and section 04, from 1.00 to 3.64. Thus, the sections 02 and 03 were considered more unstable. However, the section 03 can be considered as the most critical section due to the absence of coastal protection structures and the narrow strip of beach.

Desenvolvimento de pastas cimentantes contendo nanossílica como material estendedor para aplicação em fases iniciais, de poços petrolíferos, submetidas à baixa temperatura (5°c ± 3ºc)

The improved performance of hydraulic binders, the base of Portland cement, consists in the careful selection and application of materials that promote greater durability and reduced maintenance costs There is a wide variety of chemical additives used in Portland cement slurries for cementing oil wells. These are designed to work in temperatures below 0 ° C (frozen areas of land) to 300 ° C (thermal recovery wells and geothermal); pressure ranges near ambient pressure (in shallow wells) to greater than 200 MPa (in deep wells). Thus, additives make possible the adaptation of the cement slurries for application under various conditions. Among the materials used in Portland cement slurry, for oil wells, the materials with nanometer scale have been applied with good results. The nanossílica, formed by a dispersion of SiO2 particles, in the nanometer scale, when used in cement systems improves the plastic characteristics and mechanical properties of the hardened material. This dispersion is used commercially as filler material, modifier of rheological properties and / or in recovery processes construction. It is also used in many product formulations such as paints, plastics, synthetic rubbers, adhesives, sealants and insulating materials Based on the above, this study aims to evaluate the performance of nanossílica as extender additive and improver of the performance of cement slurries subjected to low temperatures (5 ° C ± 3 ° C) for application to early stages of marine oil wells. Cement slurries were formulated, with densities 11.0;12.0 and 13.0 ppg, and concentrations of 0; 0.5, 1.0 and 1.5%. The cement slurries were subjected to cold temperatures (5 ° C ± 3 ° C), and its evaluation performed by tests rheological stability, free water and compressive strength in accordance with the procedures set by API SPEC 10A. Thermal characterization tests (TG / DTA) and crystallographic (XRD) were also performed. The use of nanossílica promoted reduction of 30% of the volume of free water and increased compression resistance value of 54.2% with respect to the default cement slurry. Therefore, nanossílica presented as a promising material for use in cement slurries used in the early stages of low-temperature oil wells

Estudo da incorporação de resíduos de perfuração para aplicação em cimentação de poços de petróleo

During the drilling of oil and natural gas are generated solid waste, liquid and gaseous. These solid fragments, which are known as cuttings, are carried to the surface through the drilling fluid. Furthermore, this fluid serves to cool the bit, keeping the internal pressure of the well, and others. This solid residue is very polluting, because it has incorporated beyond the drilling fluid, which has several chemical additives harmful to the environment, some heavy metals that are harmful to the environment, such as lead. To minimize the residue generated, are currently being studied numerous techniques to mitigate the problems that such waste can cause to the environment, like addition of cuttings in the composition of soil cement brick masonry construction, addition of cuttings on the clay matrix for the manufacture of solid masonry bricks and ceramic blocks and coprocessing of the cuttings in cement. So, the main objective of this work is the incorporation of cuttings drilling of oil wells, the cement slurry used in the cementing operation of the well. This cuttings used in this study, arising from the formation Pendências, was milled and separated in a sieve of 100 mesh. After grinding had a mean particle sike in order of 86 mm and crystal structure containing phases of quartz and calcite type, characteristic of the Portland cement. Were formulated and prepared slurries of cement with density 13 lb / gal, containing different concentrations of gravel, and realized characterization tests API SPEC 10A and RP 10B. Free water tests showed values lower than 5.9% and the rheological model that best described the behavior of the mixtures was the power. The results of compressive strength (10.3 MPa) and stability (Dr <0.5 lb / gal) had values within the set of operational procedures. Thus, the gravel from the drilling operation, may be used as binders in addition to Portland cement oil wells, in order to reuse this waste and reduce the cost of the cement paste.

Estudo da adição de resíduos de quartzitos para obtenção de grés porcelanato

In States of Paraíba (PB) and Rio Grande do Norte (RN), northeast of Brazil, the most significant deposits of non-metallic industrial minerals are pegmatites, quartzites and granites, which are located in Seridó region. Extraction of clay, quartz, micas and feldspars occurs mainly in the cities of Várzea (PB), OuroBranco (RN) and Parelhas (RN). Mining companies working in the extraction and processing of quartzite generate large volumes of waste containing about 90% SiO2 in their chemical composition coming from quartz that is one of the basic constituents of ceramic mass for the production of ceramic coating. Therefore, this work evaluates the utilization of these wastes on fabrication of high-quality ceramic products, such as porcelain stoneware, in industrial scale. Characterization of raw materials was based on XRF, XRD, GA, TGA and DSC analysis, on samples composed by 57% of feldspar, 37% of argil and 6% of quartzite residues, with 5 different colors (white, gold, pink, green and black). Samples were synthesized in three temperatures, 1150°C, 1200°C and 1250°C, with one hour isotherm and warming-up tax of 10°C/min. After synthesizing, the specimens were submit to physical characterization tests of water absorption, linear shrinkage, apparently porosity, density, flexural strain at three points. The addition of 6% of quartzite residue to ceramic mass provided a final product with technological properties attending technical norms for the production of porcelain stoneware; best results were observed at a temperature of 1200°C. According to the results there was a high iron oxide on black quartzite, being their use in porcelain stoneware discarded by ethic and structural question, because the material fused at 1250°C. All quartzite formulations had low water absorption when synthesized at 1200°C, getting 0.1% to 0.36% without having gone through the atomization process. Besides, flexural strain tests overcame 27 MPa reaching the acceptance limits of the European Directive EN 100, at 1200°C synthesizing. Thus, the use of quartzite residues in ceramic masses poses as great potential for the production of porcelain stoneware.

Análise de microestrutura e de características geotécnicas de misturas de resíduo de polimento de porcelanato e solo

Brazil is a country in development, rich in natural resources. In order to grow sustainably, it is necessary to Brazil to preserve its environment, which is an expressive challenge, especially to industries, such as those producing ceramic materials. This study was developed using Porcelain Tile Polishing Residue (RPP) in blends with soil to build compacted fills. This residue is a slurry generated during the polishing process of porcelain tiles and contains powdery material from the polished tile, the abrasives used during the process and cooling water. The RPP was collected from a private company located in Conde/PB and it was mixed with a sandy-clayey soil, to build the fills. Laboratorial tests were conducted with pure soil, pure RPP and blends in proportions of 5%, 10%, 15% and 20% of RPP in addition to the dry mass of pure soil. The Chemical and Physical Characterization tests performed were: specific solid weight, grain size distribution, laser analysis of grain size distribution, Atterberg limits, X ray fluorescence, X ray diffraction, scanning electron microscopy and soil compaction,. The materials and blends were also compacted and direct shear tests and plate load tests were performed. Plate load tests were conducted using a circular plate with 30 cm diameter, on specimens of pure soil and 5% blend, compacted in a metallic box inside the Soil Mechanics Laboratory of the Federal University of Rio Grande do Norte, Brazil. Both mechanical tests performed were conducted under inundated conditions, willing to reduce the influence of soil suction. An evaluation of the results of the tests performed shows that RPP is a fine material, with grain size distribution smaller than 0,015mm, composed mainly of silica and alumina, and particles in angular shape. The soil was characterized as a clayey sand, geologically known as a lateritic soil, with high percentages of alumina and iron oxide, and particles with rounded shape. Both the Soil and the blends presented low plasticity, while the residue showed a medium plasticity. Direct shear tests showed that the addition of RPP did not cause major changes into blends’ friction angle data, however, it was possible to note that, for the proportions studied, that is a tendency of obtain lower shear stresses for higher percentages of RPP in the blends. Both pure soil and 5% mixture showed a punching disruption for the Plate load test. For this same test, the allowable stress for 5% mixture was 44% higher than the pure soil, and smaller vertical settlement results for all stresses.

Análise de microestrutura e de características geotécnicas de misturas de resíduo de polimento de porcelanato e solo

Brazil is a country in development, rich in natural resources. In order to grow sustainably, it is necessary to Brazil to preserve its environment, which is an expressive challenge, especially to industries, such as those producing ceramic materials. This study was developed using Porcelain Tile Polishing Residue (RPP) in blends with soil to build compacted fills. This residue is a slurry generated during the polishing process of porcelain tiles and contains powdery material from the polished tile, the abrasives used during the process and cooling water. The RPP was collected from a private company located in Conde/PB and it was mixed with a sandy-clayey soil, to build the fills. Laboratorial tests were conducted with pure soil, pure RPP and blends in proportions of 5%, 10%, 15% and 20% of RPP in addition to the dry mass of pure soil. The Chemical and Physical Characterization tests performed were: specific solid weight, grain size distribution, laser analysis of grain size distribution, Atterberg limits, X ray fluorescence, X ray diffraction, scanning electron microscopy and soil compaction,. The materials and blends were also compacted and direct shear tests and plate load tests were performed. Plate load tests were conducted using a circular plate with 30 cm diameter, on specimens of pure soil and 5% blend, compacted in a metallic box inside the Soil Mechanics Laboratory of the Federal University of Rio Grande do Norte, Brazil. Both mechanical tests performed were conducted under inundated conditions, willing to reduce the influence of soil suction. An evaluation of the results of the tests performed shows that RPP is a fine material, with grain size distribution smaller than 0,015mm, composed mainly of silica and alumina, and particles in angular shape. The soil was characterized as a clayey sand, geologically known as a lateritic soil, with high percentages of alumina and iron oxide, and particles with rounded shape. Both the Soil and the blends presented low plasticity, while the residue showed a medium plasticity. Direct shear tests showed that the addition of RPP did not cause major changes into blends’ friction angle data, however, it was possible to note that, for the proportions studied, that is a tendency of obtain lower shear stresses for higher percentages of RPP in the blends. Both pure soil and 5% mixture showed a punching disruption for the Plate load test. For this same test, the allowable stress for 5% mixture was 44% higher than the pure soil, and smaller vertical settlement results for all stresses.

Aditivo polimérico derivado de fonte renovável para aplicação em cimento asfáltico de petróleo

This study evaluated the effects of incorporating an additive from an agro-industrial residue, after some chemical modification reactions, to petroleum asphalt cement (CAP) through the polymerization reaction of a viscous polyol obtained by bagasse biomass oxypropylation reaction sugarcane with anhydrides. The polyol is obtained by biomass oxypropylation reaction with propylene oxide, the reaction was performed in an autoclave sealed with pressure and temperature control using 25 mL of OP for every 5 grams of biomass 200°C, which time reaction was two hours. The reaction is revealed by varying the system pressure, initially at atmospheric pressure to reach a maximum pressure value and its subsequent return to atmospheric pressure. For the choice of the most suitable reaction time for polymerization of the polyol with pyromellitic anhydride, the reaction was also conducted in an autoclave sealed with temperature controller (150 ° C) using 20 g of polyol, 1 g of sodium acetate (catalyst) and 8 g of pyromellitic anhydride with the times 30 and 60 minutes. The polymerized materials with different times were characterized by determining the relative viscosity and percentage content of extractable in cyclohexane / ethanol. Given the results with the polymerized material 30 minutes showed the lowest percentage content of extractives and an increased viscosity relative indicating that this time is highlighted with respect to time 60 minutes, because the material is possibly in the form of a crosslinked polymer. Given the choice of time of 30 minutes other polymerization reactions were performed with various anhydrides and other conditions employed different proportions by mass of polyol anhydrides we were referred to as condition I (20 g anhydride and 8 g of polyol), II (20 g anhydride and 20 g of polyol) and III (8 g anhydride and 20 g of polyol). The FTIR spectra of polymeric materials with different polymerization conditions used to prove the occurrence of chemical modification due to the appearance of a characteristic band ester groups (1750 cm-1) present in the polymerized material. He chose to work with the condition III, as is the condition which employs a larger amount of polyol, and even with the smaller amount of anhydride used FTIR spectra revealed that the polymerization reaction was performed. Among the various anhydrides (phthalic, maleic and pyromellitic) of the different conditions used that stood out before the solubility test with solvents analyzed was polymerized material with pyromellitic anhydride because the polymerized material likely in the form of a crosslinked polymer because it was insoluble or poorly soluble in the solvents tested. Polymerization of the polyol with pyromellitic anhydride using condition III, that is, BCPP30, CSPP30, PCPP30 e BCPPG30, provided an increase in thermal stability relative to material in the form of polyol. Applicability tests concerning the incorporation of 16% m / m BCPP30, CSPP30, PCPP30 e BCPPG30 additive in relation to the mass of 600 g CAP showed through characterization tests used, softening point, elastic recovery and marshall dosage, it is possible to use BCPP30 as an additive the conventional CAP, because even with the incorporation of this new additive modified CAP met the specifications of the appropriate standard.

influência da adição de diferentes sais em pastas de cimento portland para cimentação de poços de petróleo

One of the great challenges at present time related with the materials area concerns of products and processes for use in petroleum industry, more precisely related to the Pre-salt area. Progresses were reached in the last years allowing the drilling of the salt layer, with the time reduction for drilling and larger success at the end. For the oil wells companies the preponderant factor is the technology, however, in spite of the progress, a series of challenges is still susceptible to solutions and one of them refers to the slurries preparation for cementing in those areas. Inside of this context, this study had for objective to analyze the influence of the salts NaCl, KCl, CaSO4 and MgSO4 in strength and chemical structure of the hydrated products. As methodology, they were prepared and analyzed cement slurries with varied concentrations of these salts that are commonly found in the saline formations. The salts concentrations used in formulations of the slurries were of 5%, 15% and 30%. The slurries were formulated with specific weight of 15,8 lb / gal and the cement used was Class G. Strength tests were accomplished in samples cured by 24 hours and 28 days. Also were realized crystallographic characterization (XRD) and morphologic (SEM). In agreement with the presented results, it is observed that the largest resistance values are attributed to the slurries with concentration of 15%. There was reduction of the strength values of the slurries formulated with concentration of 30%. Through the characterization microstructural it was possible to note the salts influence in the main cement hydrated products