Mémoires du Maréchal Suchet, Duc d'Albufera, sur ses campagnes en Espagne : [Texto impreso] depuis 1808 jusqu' en 1814

V. 3 contiene el Atlas

Identification of a structural determinant for resistance to β-lactam antibiotics in Gram-positive bacteria

Streptococcus pneumoniae is the main causal agent of pathologies that are increasingly resistant to antibiotic treatment. Clinical resistance of S. pneumoniae to β-lactam antibiotics is linked to multiple mutations of high molecular mass penicillin-binding proteins (H-PBPs), essential enzymes involved in the final steps of bacterial cell wall synthesis. H-PBPs from resistant bacteria have a reduced affinity for β-lactam and a decreased hydrolytic activity on substrate analogues. In S. pneumoniae, the gene coding for one of these H-PBPs, PBP2x, is located in the cell division cluster (DCW). We present here structural evidence linking multiple β-lactam resistance to amino acid substitutions in PBP2x within a buried cavity near the catalytic site that contains a structural water molecule. Site-directed mutation of amino acids in contact with this water molecule in the “sensitive” form of PBP2x produces mutants similar, in terms of β-lactam affinity and substrate hydrolysis, to altered PBP2x produced in resistant clinical isolates. A reverse mutation in a PBP2x variant from a clinically important resistant clone increases the acylation efficiency for β-lactams and substrate analogues. Furthermore, amino acid residues in contact with the structural water molecule are conserved in the equivalent H-PBPs of pathogenic Gram-positive cocci. We suggest that, probably via a local structural modification, the partial or complete loss of this water molecule reduces the acylation efficiency of PBP2x substrates to a point at which cell wall synthesis still occurs, but the sensitivity to therapeutic concentrations of β-lactam antibiotics is lost.

First EURONEAR NEA discoveries from La Palma using the INT

Since 2006, the European Near Earth Asteroids Research (EURONEAR) project has been contributing to the research of near-Earth asteroids (NEAs) within a European network. One of the main aims is the amelioration of the orbits of NEAs, and starting in 2014 February we focus on the recovery of one-opposition NEAs using the Isaac Newton Telescope (INT) in La Palma in override mode. Part of this NEA recovery project, since 2014 June EURONEAR serendipitously started to discover and secure the first NEAs from La Palma and using the INT, thanks to the teamwork including amateurs and students who promptly reduce the data, report discoveries and secure new objects recovered with the INT and few other telescopes from the EURONEAR network. Five NEAs were discovered with the INT, including 2014 LU14, 2014 NL52 (one very fast rotator), 2014 OL339 (the fourth known Earth quasi-satellite), 2014 SG143 (a quite large NEA), and 2014 VP. Another very fast moving NEA was discovered but was unfortunately lost due to lack of follow-up time. Additionally, another 14 NEA candidates were identified based on two models, all being rapidly followed-up using the INT and another 11 telescopes within the EURONEAR network. They include one object discovered by Pan-STARRS, two Mars crossers, two Hungarias, one Jupiter trojan, and other few inner main belt asteroids (MBAs). Using the INT and Sierra Nevada 1.5 m for photometry, then the Gran Telescopio de Canarias for spectroscopy, we derived the very rapid rotation of 2014 NL52, then its albedo, magnitude, size, and its spectral class. Based on the total sky coverage in dark conditions, we evaluate the actual survey discovery rate using 2-m class telescopes. One NEA is possible to be discovered randomly within minimum 2.8 deg2 and maximum 5.5 deg2. These findings update our past statistics, being based on double sky coverage and taking into account the recent increase in discovery.

Algeria, 1856 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'Algérie, Tell, Kabylie et Sahara Algérien, dressée ... d'après les renseignements oficiels et sous la direction de ... Mr. Daumas, par C. Delaroche ; gravée par Charpentier. It was published by Longuet; Ministère de la Guerre in 1856. Scale 1:800,000. Covers northern part of Algeria and portions of Tunisia and Morocco. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Europe Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads and routes, administrative and territorial boundaries, shoreline features, forests, telegraph poles, and more.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Journées physiques ; tome second.

Mode of access: Internet.

La journée du chrétien, sanctifiée par la priere et la méditation ...

Mode of access: Internet.

Remarques sur les premiers versets du premier livre des Maccabées, ou dissertation sur une médaille d'Alexandre le Grand, du cabinet de l'Hotel-de-Ville de Lion /

Mode of access: Internet.

Histoire navale d'Angleterre, depuis la Conquête des Normands en 1066, jusqu'à la fin de l'année 1734 ... avec un grand nombre de faits et d'observations ... /

Barbier,

Les caracteres de theophraste et la suite traduits du grec avec les caracteres ou les moeurs de ce siecle ... : tome second.

Mode of access: Internet.

Sentences de l'amour diuin.

Mode of access: Internet.

Sermons pour l'avent /

Mode of access: Internet.

Sermons pour l'Avent /

Mode of access: Internet.

Les caracteres de Theophraste et la suite /

En p. 1-233: "Les caracteres ou les moeurs de ce siecle : tome premier", con portadilla, paginación y sign. propias.