Cyropaedia /

Greek and English on opposite pages.

Report of the d'Hauteville case: The commonwealth of Pennsylvania, at the suggestion of Paul Daniel Gonsalve Grand d'Hauteville, versus David Sears, Miriam C. Sears, and Ellen Sears Grand d'Hauteville. Habeas corpus for the custody of an infant child.

In the Court of general sessions for the city and county of Philadelphia. Habeas corpus for the custody of Frederick Sears Grand d'Hauteville.

Stories from English history from B. C. 55 to A. D. 1901;

Mode of access: Internet.

Illustrated English history, B.C. 55-A.D.[1886]

Mode of access: Internet.

Indian antiquities: or, Dissertations relative to the ancient geographical divisions, the pure system of primeval theology, the grand code of civil laws, the original form of government, the widely-extended commerce, and the various profound literature, of Hindostan: compared, throughout, with the religion, laws, government, and literature, of Persia, Egypt, and Greece ...

A mixed set; imprint varies: v. 1, 2, and 7 as above; v. 3 and 6: sold by John White, Luke Hansard, printer, 1801; v. 4: Printed by H.L. Galabin and sold by R. Faulder, 1800; v. 5: Printed by C. and W. Galabin and sold by W. Richardson, 1801.

Forty years in the Turkish Empire, or, Memoirs of Rev. William Goodell : late missionary of the A.B.C.F.M. at Constaninople /

Mode of access: Internet.

Who was who 5000 B. C. to date; biographical dictionary of the famous and those who wanted to be /

Mode of access: Internet.

Alsace and Lorraine from Cæsar to Kaiser, 58 B.C.-1871 A.D.,

Appendices: I. The treaties; diplomatic articles by which the political status of Alsace and Lorraine ... has been affected (p. 201-205); II. Main sources used for the narrative (p. 206-208)

The Tell el Amarna period. The relations of Egypt and western Asia in the fifteenth century B.C. according to the Tell el Amarna tablets.

"Bibliographical appendix": p. [61]-62.

T V C Â M A R A D E B A U R U PAPEL SOCIAL DO CANAL LEGISLATIVO E SUAS RELAÇÕES COM A COMUNIDADE LOCAL

Esta pesquisa analisa a TV CÂMARA canal legislativo municipal da cidade de Bauru, SP. Os objetivos foram levantar as formas de uso do canal, analisar o conteúdo da programação produzida e veiculada para a realidade bauruense, suas contribuições sociais na construção da consciência cidadã e a aceitação do canal junto ao telespectador. Os procedimentos metodológicos incluíram a observação participante, que consistiu no acompanhamento interno das atividades do canal de março de 2002 a fevereiro de 2003 e em julho de 2003. A pesquisa documental que ofereceu dados sobre estratégias da programação e entrevistas, as quais permitiram colher informações sobre participação da comunidade nos programas e sua percepção sobre o papel do canal televisivo no município. Conclui-se que o canal abriu um considerável leque de opções na televisão local. A cidade se enxerga quando assiste o canal legislativo. Ainda assim a TV Câmara precisa se solidificar no meio em que atua. A participação da sociedade pode ser ampliada com mais programas e ainda de forma mais direta, inclusive na elaboração de pautas. O mais importante: o canal é um instrumento público.

Plan of the town of Alexandria, D.C. with the environs : exhibiting the outlet of the Alexandria Canal, the shipping channel, wharves, Hunting Cr. &c. /

Relief shown by hachures. Depths shown by contours.

Recruitment and results of a pilot trial of vitamin D supplementation in the general population of Australia

Context: The benefits of high serum levels of 25-hydroxyvitamin D [25(OH)D] are unclear. Trials are needed to establish an appropriate evidence base. Objective: We plan to conduct a large-scale trial of vitamin D supplementation for the reduction of cancer incidence and overall mortality and report here the methods and results of a pilot trial established to inform its design. Design: Pilot D-Health was a randomized trial carried out in a general community setting with 12 months intervention and follow-up. Participants: Participants were 60- to 84-yr-old residents of one of the four eastern Australian states who did not have any vitamin D-related disorders and who were not taking more than 400 IU supplementary vitamin D per day. A total of 644 participants were randomized, and 615 completed the study (two persons withdrew because of nonserious adverse events). Interventions: The interventions were monthly doses of placebo or 30,000 or 60,000 IU vitamin D3. Main Outcomes: The main outcomes were the recruitment rate and changes in serum 25(OH)D. Results: Ten percent of those approached were recruited. At baseline, the mean 25(OH)D was 42 nmol/liter in all three study arms. The mean change in 25(OH)D in the placebo group was 0.12 nmol/liter, compared with changes of 22 and 36 nmol/liter in the 30,000- and 60,000-IU groups, respectively. Conclusions: The D-Health pilot has shown that a large trial is feasible in Australia and that a dose of 2000 IU/d will be needed to ensure that a large proportion of the population reaches the target serum 25(OH)D level. Copyright © 2012 by The Endocrine Society.

A concise approach to the polycyclic scaffold of frondosin D

Frondosins A−E, 1−5 (Figure 1), are a family of related marine sesquiterpenoids first isolated in their dextro-rotatory form from the sponge Dysidea frondosa.(1a) Additionally, levo-rotatory frondosins A and D were isolated from an unidentified Eurospongia species.(1b) Frondosins A−E are compounds of interest due to their promising interleukin-8 (IL-8) affinity and protein kinase C inhibition.(1a) IL-8 antagonists are of particular interest in view of their antiinflammatory,(2a) anti-HIV,(1b, 2b) and antitumor(2c-2f) properties. To date, frondosins A, B, and C have been synthesized.(3) Notwithstanding these successes, the frondosins have proved quite a formidable synthetic challenge, and as of yet, there has been no synthesis of frondosin D or E. In this report, we describe our approaches to the molecular scaffold of frondosins D. This work has culminated in a very effective means of producing the trimethylbicyclo[5.4.0]undecane ring system common to all frondosins (shown in bold, Figure 1).

Infection and cellular defense dynamics in a novel 17beta-estradiol murine model of chronic human group B streptococcus genital tract colonization reveal a role for hemolysin in persistence and neutrophil accumulation

Genital tract carriage of group B streptococcus (GBS) is prevalent among adult women; however, the dynamics of chronic GBS genital tract carriage, including how GBS persists in this immunologically active host niche long term, are not well defined. To our knowledge, in this study, we report the first animal model of chronic GBS genital tract colonization using female mice synchronized into estrus by delivery of 17β-estradiol prior to intravaginal challenge with wild-type GBS 874391. Cervicovaginal swabs, which were used to measure bacterial persistence, showed that GBS colonized the vaginal mucosa of mice at high numbers (106–107 CFU/swab) for at least 90 d. Cellular and histological analyses showed that chronic GBS colonization of the murine genital tract caused significant lymphocyte and PMN cell infiltrates, which were localized to the vaginal mucosal surface. Long-term colonization was independent of regular hormone cycling. Immunological analyses of 23 soluble proteins related to chemotaxis and inflammation showed that the host response to GBS in the genital tract comprised markers of innate immune activation including cytokines such as GM-CSF and TNF-α. A nonhemolytic isogenic mutant of GBS 874391, Δcyle9, was impaired for colonization and was associated with amplified local PMN responses. Induction of DNA neutrophil extracellular traps, which was observed in GBS-infected human PMNs in vitro in a hemolysin-dependent manner, appeared to be part of this response. Overall, this study defines key infection dynamics in a novel murine model of chronic GBS genital tract colonization and establishes previously unknown cellular and soluble defense responses to GBS in the female genital tract.