The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.

The weaver mutation in mice results in a severe ataxia that is attributable to the degeneration of cerebellar granule cells and dopaminergic neurons in the substantia nigra. Recent genetic studies indicate that the GIRK2 gene is altered in weaver. This gene codes for a G-protein-activated, inwardly rectifying K+ channel protein (8). The mutation results in a single amino acid substitution (glycine-->serine) in the pore-forming H5 region of the channel. The functional consequences of this mutation appear to depend upon the co-expression of other GIRK subunits--leading to either a gain or loss of function. Here, we show that G-protein-activated inwardly rectifying K+ currents are significantly reduced in cerebellar granule cells from animals carrying the mutant allele. The reduction is most pronounced in homozygous neurons. These findings suggest that the death of neurons in weaver is attributable to the loss of GIRK2-mediated currents, not to the expression of a nonspecific cation current.

Shape Effect of Electrochemical Chloride Extraction in Structural Reinforced Concrete Elements Using a New Cement-Based Anodic System

This article shows the research carried out by the authors focused on how the shape of structural reinforced concrete elements treated with electrochemical chloride extraction can affect the efficiency of this process. Assuming the current use of different anode systems, the present study considers the comparison of results between conventional anodes based on Ti-RuO2 wire mesh and a cement-based anodic system such as a paste of graphite-cement. Reinforced concrete elements of a meter length were molded to serve as laboratory specimens, to closely represent authentic structural supports, with circular and rectangular sections. Results confirm almost equal performances for both types of anode systems when electrochemical chloride extraction is applied to isotropic structural elements. In the case of anisotropic ones, such as rectangular sections with no uniformly distributed rebar, differences in electrical flow density were detected during the treatment. Those differences were more extreme for Ti-RuO2 mesh anode system. This particular shape effect is evidenced by obtaining the efficiencies of electrochemical chloride extraction in different points of specimens.

Intermediate (field) (direct and general support) and depot level maintenance manual : generator set, diesel engine driven, tactical skid mtd. 15 kw, 3 phase, 4 wire, 120/208 and 240/416 volts : DoD model MEP-004A ... 6115-00-463-9094.

"January 1975."

Intermediate (field) (direct and general support) and depot level maintenance manual : generator set, diesel engine driven, tactical skid mtd 5kw, 1 phase - 2 wire, 1 phase - 3 wire, 3 phase - 4 wire, 120, 120/240 and 120/208 volts, DoD model MEP-002A, class utility, hertz 60, NSN 6115-00-465-1044.

"July 1977."

Transportability guidance : tube-launched, optically-tracked, wire-guided, heavy antitank/assault weapon system (TOW) : guided missile, surface attack, BGM-71-A (in shipping container) (FSN 1410-087-1521), launcher, tubular, guided missile, M220 (FSN 1440-179-4152), carrier, guided missile equipment ... truck ... training set ... shop equipment ... contact support ....

"September 1973."

Operator and organizational maintenance manual : generator set, diesel engine driven, tactical skid mtd 5kw, 1 phase - 2 wire, 1 phase - 3 wire, 3 phase - 4 wire, 120, 120/240 and 120/208 volts : DoD model MEP-002A, class utility, hertz 60, NSN 6115-00-465-1044.

"July 1977."

Operator, organizational, field, and depot maintenance manual : welding set, ARC, inert gas shielded, plastic or metal lined gun, for 3/64 in. wire, DC, 115V, (Linde model SWM-9-A) FSN 3431-972-7672.

Includes index.

Operator's, organizational, DS, and GS maintenance manual : welding set, arc, inert gas shielded, air cooled, metal lined gun for 3/64 in. wire (Westinghouse model SA-136), FSN 3431-121-5878.

"August 1969."

Organizational, DS, GS, and depot maintenance manual including repair parts : air conditioner, floor mounting, air cooled, electric motor driven, AC, 208/416 volt, 3 phase, 4 wire, 50/60 cycle, 60,000 Btu/hr (Airflow model MAS-10-S19) FSN 4120-869-7842.

"April 1968."

Organizational, direct support, and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools) : air conditioner, 25,000 Btu, electric motor driven, 120/208V, 3 phase, 50/60 Hz, 4 wire, Ellis Watts model MOAC-336, NSN 4120-01-030-6883.

Includes index.

Operator, organizational, direct support and general support manual : air conditioner, 25,000 BTU, electric motor driven, 120/208V, 3 phase, 50/60 Hz, 4 wire, Ellis watts, model MOAC-336, NSN 4120-01-030-6883.

"February 1977."

Technical manual, operator, organizational, direct support, and general support maintenance manual : air conditioner, wall or base mounted, air cooled, self contained, electric motor driven, 6,000 BTU/hr, 115V, 1 phase, 2 wire, 50/60 hertz (Therm-air model CE-6A-60A2), FSN 4120-476-9249.

"January 1972."

Operator and organizational maintenance manual : generator set, gas turbine engine : 45 KW, AC, 120/208, 240/416V, 3 phase, 4 wire : skid mounted, winterized, (Airesearch model GTGE 70-6-1), FSN 6115-075-1639.

"24 November 1971."

Direct support and general support maintenance manual : generator set, gas turbine engine, 45 KW, AC, 120/208, 240/416 V, 3 phase, 4 wire, skid mounted, winterized (Airesearch model GTGE 70-6-1), FSN 6115-075-1639.

Includes index.

Direct and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools) : generator set, DED, wheel mtd, liquid cooled, 15KW, 400 HZ, AC, 3 phase, 4 wire,120/208 V, non-winterized, special purpose mdl SP-HF-15, w/Hercules engine D198ERX28, FSN 6115-089-5099.

Includes index.