948 resultados para Cresap, Michael, 1742-1775.


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In order to study the various health influencing parameters related to engineered nanoparticles as well as to soot emitted b diesel engines, there is an urgent need for appropriate sampling devices and methods for cell exposure studies that simulate the respiratory system and facilitate associated biological and toxicological tests. The objective of the present work was the further advancement of a Multiculture Exposure Chamber (MEC) into a dose-controlled system for efficient delivery of nanoparticles to cells. It was validated with various types of nanoparticles (diesel engine soot aggregates, engineered nanoparticles for various applications) and with state-of-the-art nanoparticle measurement instrumentation to assess the local deposition of nanoparticles on the cell cultures. The dose of nanoparticles to which cell cultures are being exposed was evaluated in the normal operation of the in vitro cell culture exposure chamber based on measurements of the size specific nanoparticle collection efficiency of a cell free device. The average efficiency in delivering nanoparticles in the MEC was approximately 82%. The nanoparticle deposition was demonstrated by Transmission Electron Microscopy (TEM). Analysis and design of the MEC employs Computational Fluid Dynamics (CFD) and true to geometry representations of nanoparticles with the aim to assess the uniformity of nanoparticle deposition among the culture wells. Final testing of the dose-controlled cell exposure system was performed by exposing A549 lung cell cultures to fluorescently labeled nanoparticles. Delivery of aerosolized nanoparticles was demonstrated by visualization of the nanoparticle fluorescence in the cell cultures following exposure. Also monitored was the potential of the aerosolized nanoparticles to generate reactive oxygen species (ROS) (e.g. free radicals and peroxides generation), thus expressing the oxidative stress of the cells which can cause extensive cellular damage or damage on DNA.

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No menos útil que la escritura de la historia para conocer lo que sucedió realmente es analizar las maneras de escribir esa misma historia para saber qué motivaciones, intenciones, fi lias o fobias latieron bajo la prosa de un historiador, un arte del que ya la misma antigüedad nos brindó excelentes ejercicios, por citar dos ejemplos ilustres, como la Maledicencia de Heródoto, de Plutarco, o el Cómo se debe escribir la historia, de Luciano de Samosata. A esa labor tan interesante se dedicó, en diciembre de 2006, un coloquio en el Institut für Geschichtswissenschaft, Abteilung Alte Geschichte de la Rheinische Friedrich- Wilhelms-Universität de Bonn y con el no menos importante motivo de festejar el octogésimo aniversario de una celebridad de la historia antigua como la del profesor Gerhard Wirth.

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Comprend : Consultation sur la discipline des avocats (mai 1775)

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Collection : French books before 1601 ; 298.2