Dresses and decorations of the Middle Ages,

Spine title: Shaw's dresses and decorations of the Middle Ages.

The story of caps and gowns,

Mode of access: Internet.

History of British costume, from the earliest period to the close of the eighteenth century.

Bibliography: p. xix-xxiv.

NYU law students reply with hangers to Secretary of Health, Education, and Welfare Joseph A. Califano's stance on "Medicaid for Abortions"

General note: Title and date provided by Bettye Lane.

Pro-ERA Demonstration and Women '80 Demonstration.

Inscription: Verso: Women '80 demonstration, New York. Around the clock watch for the ERA.

Tartuffe: Costume Design

The following thesis documents the design process and execution of Tyler Gunther’s costume design for the Theatre, Dance and Performance Studies’ production of Tartuffe. The production opened November 6, 2015 in the University of Maryland’s Kogod Theater. It was directed by Lee Mikeska Gardner with the set designed by Halea Coulter and lighting designed by Connor Dreibelbis.

Impresari, costume e societa a teatro nell'autunno della Serenissima Repubblica di Genova (1772-97)

La storiografia si interessata solo marginalmente alla vita musicale nella Genova del XVIII secolo, forse’anche scoraggiata dalla delusione espressa in una celebre dichiarazione di Charles Burney: «Genova non rispose alla mia aspettativa». Solo di recente alcuni studiosi locali, con approcci e intenti differenti, si sono interessati all’argomento senza tuttavia giungere a elaborare uno studio complessivo. Il progetto ha avviato uno studio storicamente documentato sulla gestione dei teatri a Genova nel periodo compreso tra la stesura dell’ultimo regolamento teatrale (1772) e la fine della Repubblica aristocratica (1797). La tesi si basa sullo studio di più di 3000 documenti inediti che descrivono la cessione delle tre principali sale cittadine (Teatro del Falcone, Teatro da Sant’Agostino, Teatro delle Vigne) agli impresari, i comportamenti del pubblico in sala; le opere rappresentate, l’immoralità dei ballerini e cantanti, le incidenze nei palchetti e in platea. Questi aspetti di vita teatrale quotidiana sono trattati conciliando una prospettiva storica con una sociologica. In una visione globale del teatro del XVIII secolo, l’obiettivo della tesi è quello di indagare le relazioni tra spettatori appartenenti a gruppi sociali differenti, le reazioni del pubblico, gli usi e gli obblighi di etichetta durante spettacoli e feste da ballo. Queste testimonianze non sono semplicemente pettegolezzi: esse raccontano come il teatro fosse parte integrante della vita quotidiana delle persone e come la società del XVIII secolo intendesse questo rituale d’élite. La dissertazione è correda da una cronologia degli spettacoli genovesi tra il 1772 e il 1797 e da una appendice documentaria.

Pipkiiα Is Widely Expressed In Hematopoietic-derived Cells And May Play A Role In The Expression Of Alpha- And Gamma-globins In K562 Cells.

Characterized for the first time in erythrocytes, phosphatidylinositol phosphate kinases (PIP kinases) belong to a family of enzymes that generate various lipid messengers and participate in several cellular processes, including gene expression regulation. Recently, the PIPKIIα gene was found to be differentially expressed in reticulocytes from two siblings with hemoglobin H disease, suggesting a possible relationship between PIPKIIα and the production of globins. Here, we investigated PIPKIIα gene and protein expression and protein localization in hematopoietic-derived cells during their differentiation, and the effects of PIPKIIα silencing on K562 cells. PIPKIIα silencing resulted in an increase in α and γ globins and a decrease in the proliferation of K562 cells without affecting cell cycle progression and apoptosis. In conclusion, using a cell line model, we showed that PIPKIIα is widely expressed in hematopoietic-derived cells, is localized in their cytoplasm and nucleus, and is upregulated during erythroid differentiation. We also showed that PIPKIIα silencing can induce α and γ globin expression and decrease cell proliferation in K562 cells.

Obesity And Inflammation And The Effect On The Hematopoietic System.

Bone marrow is organized in specialized microenvironments known as 'marrow niches'. These are important for the maintenance of stem cells and their hematopoietic progenitors whose homeostasis also depends on other cell types present in the tissue. Extrinsic factors, such as infection and inflammatory states, may affect this system by causing cytokine dysregulation (imbalance in cytokine production) and changes in cell proliferation and self-renewal rates, and may also induce changes in the metabolism and cell cycle. Known to relate to chronic inflammation, obesity is responsible for systemic changes that are best studied in the cardiovascular system. Little is known regarding the changes in the hematopoietic system induced by the inflammatory state carried by obesity or the cell and molecular mechanisms involved. The understanding of the biological behavior of hematopoietic stem cells under obesity-induced chronic inflammation could help elucidate the pathophysiological mechanisms involved in other inflammatory processes, such as neoplastic diseases and bone marrow failure syndromes.

Antiangiogenic And Finasteride Therapies: Responses Of The Prostate Microenvironment In Elderly Mice.

The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416+TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416+TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-β.

Egfr Activating Mutations And Their Association With Response To Platinum-doublet Chemotherapy In Brazilian Non-small Cell Lung Cancer Patients.

The aim of the study was to analyze the frequency of epidermal growth factor receptor (EGFR) mutations in Brazilian non-small cell lung cancer patients and to correlate these mutations with response to benefit of platinum-based chemotherapy in non-small cell lung cancer (NSCLC). Our cohort consisted of prospective patients with NSCLCs who received chemotherapy (platinum derivates plus paclitaxel) at the [UNICAMP], Brazil. EGFR exons 18-21 were analyzed in tumor-derived DNA. Fifty patients were included in the study (25 with adenocarcinoma). EGFR mutations were identified in 6/50 (12 %) NSCLCs and in 6/25 (24 %) adenocarcinomas; representing the frequency of EGFR mutations in a mostly self-reported White (82.0 %) southeastern Brazilian population of NSCLCs. Patients with NSCLCs harboring EGFR exon 19 deletions or the exon 21 L858R mutation were found to have a higher chance of response to platinum-paclitaxel (OR 9.67 [95 % CI 1.03-90.41], p = 0.047). We report the frequency of EGFR activating mutations in a typical southeastern Brazilian population with NSCLC, which are similar to that of other countries with Western European ethnicity. EGFR mutations seem to be predictive of a response to platinum-paclitaxel, and additional studies are needed to confirm or refute this relationship.

Intermittent Fasting Induces Hypothalamic Modifications Resulting In Low Feeding Efficiency, Low Body Mass And Overeating.

Intermittent fasting (IF) is an often-used intervention to decrease body mass. In male Sprague-Dawley rats, 24 hour cycles of IF result in light caloric restriction, reduced body mass gain, and significant decreases in the efficiency of energy conversion. Here, we study the metabolic effects of IF in order to uncover mechanisms involved in this lower energy conversion efficiency. After 3 weeks, IF animals displayed overeating during fed periods and lower body mass, accompanied by alterations in energy-related tissue mass. The lower efficiency of energy use was not due to uncoupling of muscle mitochondria. Enhanced lipid oxidation was observed during fasting days, whereas fed days were accompanied by higher metabolic rates. Furthermore, an increased expression of orexigenic neurotransmitters AGRP and NPY in the hypothalamus of IF animals was found, even on feeding days, which could explain the overeating pattern. Together, these effects provide a mechanistic explanation for the lower efficiency of energy conversion observed. Overall, we find that IF promotes changes in hypothalamic function that explain differences in body mass and caloric intake.