Experimental investigation of truck tire inflation pressure on pavement-tire contact area and pressure distribution. Interim report.

Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin

Dīwān al-Kāshif : min sanat 1315 ilʹa sanat 1320 /

Title also in French.

Proceedings of the United States senate and the House of representatives in the trial of impeachment of Robert W. Archbald, additional circuit judge of the United States from the third judicial circuit and designated a judge of the Commerce court.

Mode of access: Internet.

“A Man After God’s Own Heart”: Biblical, Hegemonic and Toxic Masculinities in As Meat Loves Salt

Maria McCann paints a dark picture of masculinity and its effects in her novel As Meat Loves Salt (2001). The violent Jacob Cullen struggles with his masculinity as he faces the intricacies of religion, sexuality and politics in the midst of the English Civil War where he falls in love with fellow soldier Christopher Ferris. By using R.W. Connell and James Messerschmidt’s framework for the hierarchy of masculinities, I explore masculinities on local, regional and global levels and emphasized femininity in a close reading of McCann’s novel. My aim is not only to analyse the masculinities of the novel but also to use the framework to redefine toxic masculinity in order to make it a useable concept when analysing masculinities in literature. I redefine toxic masculinity because it lacks a clear definition anchored in an established framework used to study masculinity that does not see masculinity as inherently toxic. I believe that anchoring it to Connell and Messerschmidt’s framework will make it a useable concept. Due to the novel’s relationship to the Bible, I will use masculinity studies done on David and Jesus from the Bible to compare and reveal similarities with the masculinities in the novel, how they appear on the local, regional and global levels in the novel and its effects. I draw parallels between the love story in As Meat Loves Salt to the love story of David and Jonathan in the Bible by using queer readings of David and Jonathan in order to explore how masculinity affects the relationships and how the novel uses these two love stories as a study of toxic masculinity and how it relates it to hegemonic masculinity.

Data compilation on the biological response to ocean acidification: environmental and experimental context of data sets and related literature

The exponential growth of studies on the biological response to ocean acidification over the last few decades has generated a large amount of data. To facilitate data comparison, a data compilation hosted at the data publisher PANGAEA was initiated in 2008 and is updated on a regular basis (doi:10.1594/PANGAEA.149999). By January 2015, a total of 581 data sets (over 4 000 000 data points) from 539 papers had been archived. Here we present the developments of this data compilation five years since its first description by Nisumaa et al. (2010). Most of study sites from which data archived are still in the Northern Hemisphere and the number of archived data from studies from the Southern Hemisphere and polar oceans are still relatively low. Data from 60 studies that investigated the response of a mix of organisms or natural communities were all added after 2010, indicating a welcomed shift from the study of individual organisms to communities and ecosystems. The initial imbalance of considerably more data archived on calcification and primary production than on other processes has improved. There is also a clear tendency towards more data archived from multifactorial studies after 2010. For easier and more effective access to ocean acidification data, the ocean acidification community is strongly encouraged to contribute to the data archiving effort, and help develop standard vocabularies describing the variables and define best practices for archiving ocean acidification data.

What is this thing called Historical Archaeology?

Historical archaeology, in its narrow temporal sense -as an archaeology of the emergence and subsequent evolution of the Modern world- is steadily taking pace in Spanish academia. This paper aims at provoking a more robust debate through understanding how Spanish historical archaeology is placed in the international scene and some of its more relevant particularities. In so doing, the paper also stresses the strong links that have united historical and prehistorical archaeology since its inception, both in relation to the ontological, epistemological and methodological definition of the first as to the influence of socio-political issues in the latter. Such reflection is partly a situated reflection from prehistory as one of the paper���s authors has been a prehistorian for most of her professional life.

Polskie czasopisma z nauk humanistycznych i nauk społecznych w liczbach

Raport zawiera dane naukometryczne na temat 818 polskich czasopism naukowych z obszaru nauk humanistycznych i społecznych poddanych ewaluacji i umieszczonych na trzech Wykazach czasopism punktowanych opublikowanych w latach: 2012, 2013 i 2015. Analizowaliśmy zmiany punktacji poszczególnych czasopism jak r��wnież rozkład punktów dla czasopism przyporządkowanych do danej dyscypliny naukowej z obszaru nauk humanistycznych i społecznych. Uwzględniliśmy wyłącznie czasopisma znajdujące się we wszystkich trzech wykazach w części B. Nie uwzględniliśmy natomiast czasopism, które w trakcie tych lat były indeksowane na r��żnych częściach Wykazu czasopism punktowanych, np. w wykazie z 2013 r. znajdowały się w części C, a w 2015 r. zostały przeniesione do części B. Redakcje w ankiecie ewaluacyjnej wskazywały jedną lub dwie dyscypliny podstawowe, w ramach których funkcjonuje czasopismo. Dyscypliny były wskazywane zgodnie z Rozporządzeniem Ministra Nauki i Szkolnictwa Wyższego z dnia 8 sierpnia 2011 r. w sprawie obszar��w wiedzy, dziedzin nauki i sztuki oraz dyscyplin naukowych i artystycznych (Dz.U. 2011 nr 179 poz. 1065). Dane: stan na 31 grudnia 2015 r.

Development And Characterization Of Microsatellite Loci For Ocotea Species (lauraceae) Threatened With Extinction.

The Atlantic rainforest species Ocotea catharinensis, Ocotea odorifera, and Ocotea porosa have been extensively harvested in the past for timber and oil extraction and are currently listed as threatened due to overexploitation. To investigate the genetic diversity and population structure of these species, we developed 8 polymorphic microsatellite markers for O. odorifera from an enriched microsatellite library by using 2 dinucleotide repeats. The microsatellite markers were tested for cross-amplification in O. catharinensis and O. porosa. The average number of alleles per locus was 10.2, considering all loci over 2 populations of O. odorifera. Observed and expected heterozygosities for O. odorifera ranged from 0.39 to 0.93 and 0.41 to 0.92 across populations, respectively. Cross-amplification of all loci was successfully observed in O. catharinensis and O. porosa except 1 locus that was found to lack polymorphism in O. porosa. Combined probabilities of identity in the studied Ocotea species were very low ranging from 1.0 x 10-24 to 7.7 x 10-24. The probability of exclusion over all loci estimated for O. odorifera indicated a 99.9% chance of correctly excluding a random nonparent individual. The microsatellite markers described in this study have high information content and will be useful for further investigations on genetic diversity within these species and for subsequent conservation purposes.

Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil

The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways. A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associated with susceptibility to human cancers. Recently, another TP53 SNP at codon 47 (Pro47Ser) was reported to have a low apoptosis-inducing ability; however, there are no association studies between this SNP and cancer. Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of these SNPs in 94 gliomas (81 astrocytomas, 8 ependymomas and 5 oligodendrogliomas) and in 100 healthy subjects by the polymerase chain reaction-restriction fragment length polymorphism approach. Chi-square and Fisher exact test comparisons for genotype distributions and allele frequencies did not reveal any significant difference between patients and control groups. Overall and disease-free survivals were calculated by the Kaplan-Meier method, and the log-rank test was used for comparisons, but no significant statistical difference was observed between the two groups. Our data suggest that TP53 Pro47Ser and Arg72Pro SNPs are not involved either in susceptibility to developing gliomas or in patient survival, at least in the Brazilian population.

Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors

The cancer is one of the most common and severe problems in clinical medicine, and nervous system tumors represent about 2% of the types of cancer. The central role of the nervous system in the maintenance of vital activities and the functional consequences of the loss of neurons can explain how severe brain cancers are. The cell cycle is a highly complex process, with a wide number of regulatory proteins involved, and such proteins can suffer alterations that transform normal cells into malignant ones. The INK4 family members (CDK inhibitors) are the cell cycle regulators that block the progression of the cycle through the R point, causing an arrest in G1 stage. The p14ARF (alternative reading frame) gene is a tumor suppressor that inhibits p53 degradation during the progression of the cell cycle. The PTEN gene is related to the induction of growth suppression through cell cycle arrest, to apoptosis and to the inhibition of cell adhesion and migration. The purpose of the present study was to assess the mutational state of the genes p14ARF, p15INK4b, p16INK4a, and PTEN in 64 human nervous system tumor samples. Homozygous deletions were found in exon 2 of the p15INK4b gene and exon 3 of the p16INK4a gene in two schwannomas. Three samples showed a guanine deletion (63 codon) which led to a loss of heterozygosity in the p15 gene, and no alterations could be seen in the PTEN gene. Although the group of patients was heterogeneous, our results are in accordance with other different studies that indicate that homozygous deletion and loss of heterozygosity in the INK4 family members are frequently observed in nervous system tumors.

GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas

Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of developing some types of tumors. We examined GSTP1 Ile105Val polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples. Patients who had the Val allele of the GSTP1 Ile105Val polymorphism had an increased risk of tumor development (odds ratio = 8.60; 95% confidence interval = 4.74-17.87; P < 0.001). Overall survival of patients did not differ significantly. We suggest that GSTP1 Ile105Val polymorphisms are involved in susceptibility to developing astrocytomas and glioblastomas.

Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma

Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar functions. Like p53, p73 can bind to DNA and activate transcription. Using PCR-SSCP and gene sequencing, we analyzed the TP53 and TP73 genes in a case of a grade III anaplastic astrocytoma that progressed to glioblastoma. We found a deletion of AAG at position 595-597 of TP53 (exon 6), resulting in the deletion of Glu 199 in the protein and a genomic polymorphism of TP73, identified as an A-to-G change, at position E8/+15 at intron 8 (IVS8-15A>G). The mutation found at exon 6 of the gene TP53 could be associated with the rapid tumoral progression found in this case, since the mutated p53 may inactivate the wild-type p53 and the p73 alpha protein, which was conserved here, leading to an increase in cellular instability.