Affidavit of the administrators of the estate of Hannah Lee, 17 January 1788

Handwritten affidavit declaring Isaac Story of Marblehead, Mass. the executor of the estate of Hannah Lee, with the estate's proceeds to be distributed to Thomas and Sarah Fayerweather, Thomas Hubbard Townsend of Needham, and Andrew and Mary Bordman of Tewksbury. The affidavit also appoints London merchants to recover lands in England.

A proof of Jesus Christ's being the ancient promised Messiah: a sermon preached in the Chapel of Harvard College at Cambridge in New England, June 23, 1756

The hand-sewn notebook contains a 24-page manuscript draft of the second Dudleian lecture, delivered by John Barnard on June 23, 1756. The copy includes a small number of edits and struck-out words adopted in the printed version published by J. Draper of Boston in 1756. The sermon begins with the Biblical text Mark 14:61, 62. The covers are no longer with the item.

The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes

Tricyclo-DNA (tcDNA) is a sugar-modified analogue of DNA currently tested for the treatment of Duchenne muscular dystrophy in an antisense approach. Tandem mass spectrometry plays a key role in modern medical diagnostics and has become a widespread technique for the structure elucidation and quantification of antisense oligonucleotides. Herein, mechanistic aspects of the fragmentation of tcDNA are discussed, which lay the basis for reliable sequencing and quantification of the antisense oligonucleotide. Excellent selectivity of tcDNA for complementary RNA is demonstrated in direct competition experiments. Moreover, the kinetic stability and fragmentation pattern of matched and mismatched tcDNA heteroduplexes were investigated and compared with non-modified DNA and RNA duplexes. Although the separation of the constituting strands is the entropy-favored fragmentation pathway of all nucleic acid duplexes, it was found to be only a minor pathway of tcDNA duplexes. The modified hybrid duplexes preferentially undergo neutral base loss and backbone cleavage. This difference is due to the low activation entropy for the strand dissociation of modified duplexes that arises from the conformational constraint of the tc-sugar-moiety. The low activation entropy results in a relatively high free activation enthalpy for the dissociation comparable to the free activation enthalpy of the alternative reaction pathway, the release of a nucleobase. The gas-phase behavior of tcDNA duplexes illustrates the impact of the activation entropy on the fragmentation kinetics and suggests that tandem mass spectrometric experiments are not suited to determine the relative stability of different types of nucleic acid duplexes.

Attic tragedies : Sophocles, Euripides, Aeschylus.

Oedipus, Antigone and Electra are translated by Robert Whitelaw, Medea and Hippolytus by Arthur S. Way. The name of the translator of Prometheus bound is not given.

The early days of railroads in Fitchburg /

Mode of access: Internet.

The Hull-Easton correspondence during the expedition against Tripoli, 1804-1805;

Mode of access: Internet.

The Odes & Epodes of Horace : Latin text /

Printed by H.O. Houghton & Co., Cambridge, Mass.

Supplementary concordance to the minor Italian works of Dante,

Mode of access: Internet.

Catalogue of the historical collection and pictures in Pilgrim hall, Plymouth.

Mode of access: Internet.

Year book.

The volumes contain miscellaneous contributions by various authors, annual reports of the organization, list of members, etc.

Catalogue of the ... annual exhibition ...

First and second exhibitions were held in connection with the 2d-3d annual exhibitions of the Columbian Society of Artists, Philadelphia and were issued with that title.

Proceedings of the first ten years. To which is added a brief view of the principal religious tract societies throughout the world.

Mode of access: Internet.

An abstract of a letter to Cotton Mather of Boston in New England /

Mode of access: Internet.

The name of Christian the only appropriate name for believers in Christ. A sermon, preached at the dedication of the Third Congregational Church in Cambridge. Dec. 25, 1827. ...

Half-title: Dr. Lowell's dedication sermon.

Christian hymns : adapted to the worship of God our saviour in public and private devotion /

Includes indexes.