Dihydropyrimidinase and β-ureidopropionase gene variation and severe fluoropyrimidine-related toxicity

AIMS To assess the association of DPYS and UPB1 genetic variation, encoding the catabolic enzymes downstream of dihydropyrimidine dehydrogenase, with early-onset toxicity from fluoropyrimidine-based chemotherapy. PATIENTS & METHODS The coding and exon-flanking regions of both genes were sequenced in a discovery subset (164 patients). Candidate variants were genotyped in the full cohort of 514 patients. RESULTS & CONCLUSIONS Novel rare deleterious variants in DPYS (c.253C > T and c.1217G > A) were detected once each in toxicity cases and may explain the occurrence of severe toxicity in individual patients, and associations of common variants in DPYS (c.1-1T > C: padjusted = 0.003; OR = 2.53; 95% CI: 1.39-4.62, and c.265-58T > C: padjusted = 0.039; OR = 0.61; 95% CI: 0.38-0.97) with 5-fluorouracil toxicity were replicated.

Lifetime prevalence and risk factors for cancer in a Mexican American population with severe health disparities: The Cameron County Hispanic Cohort

Retrospective data from the Cameron Country Hispanic Cohort (1) were analyzed to assess the burden of cancer in the Mexican American population living in Brownsville TX. Data provided by the study participants for themselves and their parents and other extended relatives on cancer and related risk factors were used to determine both the prevalence of cancer and these risk factors as well as any associations between them. Lifetime incidence of cancer among the study participants was of 2.8%. Lifetime incidence of cancer among the parents of the study population was calculated for cancer in general and for specific cancer sites to determine the ranking of occurrence of each type of cancer. Some cancer types in this population were ranked higher than what would be expected when compared with national data from Hispanics in the U.S, these were: Liver cancer (3rd vs. 7th nationally in males and 6th vs. 13th nationally in females), stomach cancer (4th vs. 8th nationally in males and 5th vs. 11th nationally in females) and ovarian cancer (3rd vs. 8th nationally in females). A significant association with cancer was found for being born in the United States compared to being born elsewhere (O.R. 1.62, 95% C.I. 1.01–2.60) among study participants and the same association was also found between birth of parents in the United States regardless of gender for cancers in general (O.R. 1.38 95% C.I. 1.12–1.70), stomach cancer (O.R. 1.92 95% C.I. 1.01–3.67) and colorectal cancer (O.R. 2.93 95% C.I. 1.28–6.72). Having been born in the United States and having a family history of cancer was also found to be significantly associated with other risk factors for cancer such as obesity, diabetes and insulin resistance, both among the parents and the participant population, suggesting these interactions are complex. These high rates of cancer and particular prominence of less usual cancer such as liver and ovary in health disparities warrant evaluation of early detection strategies.^

L. Annaei Senecae Ad aebutium liberalem De Beneficiis libri VII : Ad Neromen Caesarem De Clementia libri II. Ad novautm De ira libri III /

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L. Annaei Senecae Dialogi IX : Ad Lucilium Naturalium quaestionum libri VII. Ludus de morte Claudii /

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L. Annaei Senecae philosophi opera omnia ex ult. I. Lipsii emendatione et M. Annaei Senecae rhetoris quae exstant ex And. Schotti recens.

La obra de Marco Anneo Séneca con portada y paginación propias.

L. Annaei Senecae Pars secunda sive Opera declamatoria /

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Iusti Lipsi Manuductionis ad stoicam philosophiam Libri tres : L. Annaeo Senecae, Aliisque scriptoribus illustrandis.

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Iusti Lipsi Physiologiae stoicorum libre tres L. Annaeo Senecae aliisque scriptoribus illustrandis.

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L' esprit de Seneque , ou Les plus belles Pensées de ce Grand Philosophe : einsegnant l'art de bien vivre. Pour servir de guide à conduire nos passions, pratiquer la vertu, & fuïr les vices ...

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Lelio o Diálogo de Marco Tulio Cicerón sobre la amistad... seguida de algunos fragmentos de Séneca sobre la amistad... y de la refutación que hace Tulio en el libro de Finibus de la doctrina de Epicuro, aplicada a la amistad /

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Oeuvres de Séneque le Philosophe /

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Oeuvres de Séneque le Philosophe /

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Oeuvres de Séneque le Philosophe /

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Oeuvres de Séneque le Philosophe /

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