180 resultados para Carlton
Resumo:
Mos is an upstream activator of mitogen-activated protein kinase (MAPK) and, in mouse oocytes, is responsible for metaphase II arrest. This activity has been likened to its function in Xenopus oocytes as a component of cytostatic factor. Thus, Mos-deficient female mice (MOS-/-) are less fertile and oocytes derived from these animals fail to arrest at metaphase II and undergo parthenogenetic activation [Colledge, W. H., Carlton, M. B. L., Udy, C. B. & Evans, M. J. (1994) Nature (London) 370, 65-68 and Hashimoto, N., Watanabe, N., Furuta. Y., Tamemoto, B., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. & Aizawa, S. (1994) Nature (London) 370, 68-71]. Here we show that maturing MOS-/- oocytes fail to activate MAPK throughout meiosis, while p34cdc2 kinase activity is normal until late in metaphase II when it decreases prematurely. Phenotypically, the first meiotic division of MOS-/- oocytes frequently resembles mitotic cleavage or produces an abnormally large polar body. In these oocytes, the spindle shape is altered and the spindle fails to translocate to the cortex, leading to the establishment of an altered cleavage plane. Moreover, the first polar body persists instead of degrading and sometimes undergoes an additional cleavage, thereby providing conditions for parthenogenesis. These studies identify meiotic spindle formation and programmed degradation of the first polar body as new and important roles for the Mos/MAPK pathway.
Resumo:
The increased prevalence of multidrug-resistant bacterial pathogens motivated us to attempt to enhance the therapeutic efficacy of bacteriophages. The therapeutic application of phages as antibacterial agents was impeded by several factors: (i) the failure to recognize the relatively narrow host range of phages; (ii) the presence of toxins in crude phage lysates; and (iii) a lack of appreciation for the capacity of mammalian host defense systems, particularly the organs of the reticuloendothelial system, to remove phage particles from the circulatory system. In our studies involving bacteremic mice, the problem of the narrow host range of phage was dealt with by using selected bacterial strains and virulent phage specific for them. Toxin levels were diminished by purifying phage preparations. To reduce phage elimination by the host defense system, we developed a serial-passage technique in mice to select for phage mutants able to remain in the circulatory system for longer periods of time. By this approach we isolated long-circulating mutants of Escherichia coli phage lambda and of Salmonella typhimurium phage P22. We demonstrated that the long-circulating lambda mutants also have greater capability as antibacterial agents than the corresponding parental strain in animals infected with lethal doses of bacteria. Comparison of the parental and mutant lambda capsid proteins revealed that the relevant mutation altered the major phage head protein E. The use of toxin-free, bacteria-specific phage strains, combined with the serial-passage technique, may provide insights for developing phage into therapeutically effective antibacterial agents.
Resumo:
Back Row: Fred Mushinski, Jerry Hanlon, Lloyd Carr, Fritz Seyferth, Jerry Meter, Ron Vanderlinden, Milan Wooletich, Mike Gittleson, Les Miles, Paul Schudel, Bob Thornbladh, Bill McCartney, Tim Davis, Tirrel Burton
8th Row: Dennis Hammond, Jon Falk, Brad Maxon, Mike Melnyk, Fritz Burgess, Roger Joseph, John Lanman, Rolie Zagnoli, John Ferens, Larry Cerasi, Jeff Nate, Cedric Smith, Russ Miller
7th Row: Evan Cooper, Vincent Bean, Tom Dixon, Glen Dwyer, Nate Rodgers, Jeff Shaw, Mike Wilson, Larry Sweeney, Ron Prusa, Doug James, Bob Dana, Mike Boren, Carlton Rose, Tim Anderson
6th Row: Don Bracken, Greg Armstrong, Kerry Smith, Steve Smith, Dave Hall, Vince DeFelice, Stefan Humphries, Milt Carthens, Rod Lyles, Jerry DiOrio, Dave Meredith, Harry Gosier, Tom Hassel, Greg Powell
5th Row: Ali Haji-Sheikh, Nate Davis, Ricky Davis, John Lott, Duke Haynes, Jim Herrmann, Dan Yarano, Todd Triplett, Joe Mosketti, Scott Roberts, Marshall Parks, Kevin Smith, Bill Jacoby, Frank Raiford
4th Row: Anthony Carter, Larry Ricks, Rich Hewlett, Jerry Burgei, Keith Bostic, Jerald Ingram, Winfred Carraway, Craig Dunaway, Tom Neal, Vincent Shaw, Jeff Cohen, Don Ryan, Brad Fischer, Paul Girgash, Kenny Gear
3rd Row: Mike Czarnota, Fred Brockington, Robert Thompson, Jeff Felten, Tom Garrity, Bubba Paris, Ed Muransky, Rich Strenger, Mike Lemirande, Mark Warth*, Zeke Wallace, Cedric Coles, Sanford Washington, Tony Kelsie
2nd Row: Oliver Johnson, Brian Carpenter, Tony Jackson, Butch Woolfolk, Jim Breaugh, Fred Motley, Chuck Christian, Kelly Keough, Tom Wandersleben, Brad Bates, Norm Betts, Jeff Reeves, Marion Body, Karl Tech
Front Row: Alan Mitchell, Tony Osbun, Kurt Becker, Mike Trgovac, John Wangler, George Lilja, Mel Owens, John Powers, Gerald Diggs, Andy Cannavino, Dave Nicolau, Stan Edwards, Rod Feaster, Stu Harris, Coach Bo Schembechler
* = left the team
Resumo:
Back Row: Fritz Seyferth, Bob Chmiel, Alex Agase, Jerry Meter, Elliot Uzelac, Paul Schudel, Jerry Hanlon, Gary Moeller, Tirrell Burton, Milan Vooletich, Lloyd Carr, Bob Thornbladh, Dennis Doornbos, Mike Gittleson
9th Row: Chuck Ritter, Jon Falk, Ken Gear, Bob Kimball, Ed Hood, Camp Fellin, Marc Shevrin, Joe Mosketti, Charlie Fromm, Russ Miller
8th Row: Pat Moons, Derek Woodmore, Greg Randall, Triando Markray, Andy Moeller, Mike Krauss, Dan Decker, Jerry Quaerna, Rick Frazer, Dieter Heren, Ben Logue, Keith Cowan, Robert Harris
7th Row: Tony Gant, Steve Johnson, Thomas Wilcher, Eddie Garrett, Paul Schmerge, Mike Reinhold, Marty Shimko, John Mihic, Mark Hammerstein, Jim Harbaugh, Dan Rice, Bob Perryman, Gilvanni Johnson, Ivan Hicks
6th Row: Joe English, Todd Schlopy, Mike Melnyk, John Ferens, Mike Sessa, John Ghindia, Sim Nelson, Gil Zimmerman, Eric Kempthorn, Bruce Brown, Dave Simon, Sylvester Ogletree, John Paciorek, Bob Bergeron
5th Row: Tom Knoebel, Mike Odioso, Phil Lewandowski, Bob Popowski, Clay Miller, Jeff Akers, Kevin Brooks, Art Balourdos, Mike Hammerstein, Brian Mercer, Bob Tabachino, Joe Gray, Jim Scarcelli, Riley McPhee
4th Row: Greg Powell, Brad Cochran, Al Sincinch, Mike Mallory, Eric Kattus, Vince DeFelice, Tim Anderson, Dave Meredith, Larry Sweeney, Mike Wilson, Nate Rodgers, Robert Dana, Rick Rogers, Fritz Burgess
3rd Row: Evan Cooper, Greg Armstrong, Don Bracken, Carlton Rose, Tom Hassell, Kerry Smith, Dave Hall, Jerry Diorio, Ron Prusa, Milt Carthens, Doug James, Rodney Lyles, Mickey Hanlon, Lou Kovacs
2nd Row: Vince Bean, Stefan Humphries, Nate Davis, Ricky Davis, John Lott, Scott Roberts, Todd Triplett, Dan Yarano, Rich Hewlett, Jeff Cohen, Jim Herrman, Steve Smith, Mike Boren, Tom Dixon
Front Row: Marion Body, Jerald Ingram, Mike Lemirande, Winfred Carraway, Craig Dunaway, Keith Bostic, Rich Strenger, Robert Thompson, Anthony Carter, Lawrence Ricks, Paul Girgash, Tom Garrity, Jerry Burgei, Ali Haji-Sheikh, Bo Schembechler
Resumo:
Back Row: Bill Giarmo, Alex Agase, Jerry Hanlon, Bob Thornbladh, Elliott Uzelac, Gary Moeller, Lloyd Carr, Jerry Meter, Milan Vooletich, Tirrel Burton, Bob Chmiel, Jim Herrmann, Dave Magazu
9th Row: Doug Ham (Mgr.), Mike Gittleson, Lou Kovacs, Joe English, Joe Mosketti, James Rott, Garrett Smith, Phil Logas, John Whitledge, Andy Samosiuk, Dave Garlow, Russ Miller, Fritz Seyferth, Jon Falk
8th Row: Tim Schulte, Mike O'Connor, Billy Harris, Carlitos Bostic, Gene Cecchini, Steve Thibert, Jack Walker, John Balourdos, Pete Wentworth, Todd Schulte, Brandon Johns, Monte Robbins, John Zingales
7th Row: Billy Dawson, Doug Mallory, Gerald White, Garland Rivers, Dave Folkertsma, Andrew Borowski, Glenn Mogle, John Elliott, Andree McIntyre, Dwayne Freeman, Phil Webb, Chris Zurbrugg, Ken Higgins, Russell Rein
6th Row: Gene Lawson, Camp Fellin, Marc Shevrin, Dieter Heren, John Mihic, Jerry Quaerna, Rick Frazer, Marty Shimko, Triando Markray, Dan Decker, Keith Cowan, Pat Moons, Ed Hood, Al Bishop
5th Row: Steve Johnson, Tony Gant, Greg Randall, Ben Logue, Gilvanni Johnson, Paul Schmerge, Mark Hammerstein, Mike Reinhold, Jim Harbaugh, Bob Perryman, Andy Moeller, Mike Krauss, Ivan Hicks
4th Row: Mike Melnyk, Todd Schlopy, John Paciorek, Dave Simon, John Ghindia, Phil Lewandowski, Jim Scarcelli, Brad Cochran, Tom Knoebel, Mike Sessa, Eddie Garrett, Dan Rice, John Ferens, Bob Bergeron, Tom Wilcher
3rd Row: Joe Gray, Mike Mallory, Clay Miller, Eric Kattus, Art Balourdos, Al Sincich, Kevin Brooks, Mike Hammerstein, Sim Nelson, Jeff Akers, Rick Rogers, Bob Popowski, Bob Tabachino, Brian Mercer
2nd Row: Fritz Burgess, Tim Anderson, Mike Wilson, Nate Rogers, Dave Meredith, Vince DeFelice, Greg Armstrong, Milt Carthens, Rodney Lyles, Larry Sweeney, Dan Yarano, Gerald Ingram, Don Bracken, Kerry Smith
Front Row: Jeff Cohen, Jerry Diorio, Dave Hall, Carlton Rose, Steve Smith, Tom Dixon, Stefan Humphries, Mike Boren, Doug James, Evan Cooper, Tom Hassel, John Lott, Vince Bean, Rich Hewlett, Coach Bo Schembechler
Resumo:
Front Row: Cheryl Pearcy, Kari Kunnen, Kathryn Gleason, Karla Kunnen, Patti Benedict, assistant coach Cathy Wylie,
Middle Row: manager Tim Dryer, Tracy Carr, Erin Martino, Kathleen Berrigan, Lesa Arvia, Mary Campana
Back Row: Amy Carlton (Sports Information), student trainer Amy Brim, athletic trainer Kate Hallada, Renee Swinicki, Kelly Forbis, Kelly Kovach, Michelle Silver, Kim Clark, assistant coach Carol Bruggeman, head coach Carol Hutchins
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Running title: Analyses of crude petroleums of the United States.
Resumo:
Mode of access: Internet.
Resumo:
Prepared for U. S. Environmental Protection Agency, Office of Solid Waste Management Programs.
Resumo:
Bibliography at end of each unit.
Resumo:
At head of title: NASA space vehicle design criteria (chemical propulsion).
Resumo:
"A Reflection book."
Resumo:
Mode of access: Internet.
