Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy: a prospective study

BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question. So far, its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial. METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012. After written informed consent, all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible, were included in the study. Upon completion of lung resection, a catheter was placed in the proximal paraphrenic tissue on the pericardial surface. After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy. The controlled, temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1% at a rate of 3 mL/h (30 mg/h) via the above-mentioned catheter. RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation. Spirometry showed a significant decrease in dynamic lung volumes (forced expiratory volume in 1 second and forced vital capacity; p < 0.05) with the paralyzed hemidiaphragm. Blood oxygen saturation levels did not change significantly. CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy. Therefore, in these already compromised patients, intraoperative phrenic nerve injury should be avoided whenever possible.

Diversificación con frambuesa : : el impacto de su introducción en sistemas hortícolas de Coronda, Santa Fe, Argentina : análisis de un caso de estudio

El objetivo del presente trabajo fue analizar el impacto micro-económico que produce la introducción del cultivo de frambuesa en una pyme hortícola de Coronda, dedicada esencialmente a la producción de frutillas.El patrón de diversificación actual es escaso, debido principalmente a las limitaciones financieras existentes a nivel predial. Se combina el cultivo de frutilla con otras hortalizas, a contra-ciclo, tales como zapallito, berenjena, choclo, sandía y melón. Se analizaron los resultados económicos del ejercicio 2009/2010 de una empresa pyme, estudiada como caso, con una Superficie Agrícola Útil de 5,5 ha, que implantó en el ejercicio evaluado 2 ha de frutilla e introdujo 0,5 ha de frambuesa al esquema productivo, en reemplazo de alguno de los cultivos hortícolas que realizaba. Se obtuvo un Ingreso al capital equivalente a $ 59.786, una rentabilidad sobre el capital total de 12,95 % y sobre el capital sin tierra de 28,79 %. Estos tres indicadores mostraron un incremento de 258%, 248% y 236% respecto de la situación sin frambuesa, respectivamente. Se mejora el grado de diversificación analizado a través del Índice de Entropía y exhibe una excelente complementariedad tanto en el aspecto financiero como laboral.

Las nuevas tecnologías de la información y comunicación como herramientas al servicio de la calidad educativa

Fil: Palacios, Analía Mirta. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Las nuevas tecnologías de la información y comunicación como herramientas al servicio de la calidad educativa

Fil: Palacios, Analía Mirta. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse

Heterozygous reeler mice (HRM) haploinsufficient for reelin express ≈50% of the brain reelin content of wild-type mice, but are phenotypically different from both wild-type mice and homozygous reeler mice. They exhibit, (i) a down-regulation of glutamic acid decarboxylase 67 (GAD67)-positive neurons in some but not every cortical layer of frontoparietal cortex (FPC), (ii) an increase of neuronal packing density and a decrease of cortical thickness because of neuropil hypoplasia, (iii) a decrease of dendritic spine expression density on basal and apical dendritic branches of motor FPC layer III pyramidal neurons, and (iv) a similar decrease in dendritic spines expressed on the basal dendrite branches of CA1 pyramidal neurons of the hippocampus. To establish whether the defect of GAD67 down-regulation observed in HRM is responsible for neuropil hypoplasia and decreased dendritic spine density, we studied heterozygous GAD67 knockout mice (HG67M). These mice exhibited a down-regulation of GAD67 mRNA expression in FPC (about 50%), but they expressed normal amounts of reelin and had no neuropil hypoplasia or down-regulation of dendritic spine expression. These findings, coupled with electron-microscopic observations that reelin colocalizes with integrin receptors on dendritic spines, suggest that reelin may be a factor in the dynamic expression of cortical dendritic spines perhaps by promoting integrin receptor clustering. These findings are interesting because the brain neurochemical and neuroanatomical phenotypic traits exhibited by the HRM are in several ways similar to those found in postmortem brains of psychotic patients.

Le pitture e sculture di Brescia che sono esposte al pubblico : con un'appendice di alcune private gallerie.

University of Illinois Library bookplate "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921" on the inside front cover.

Storia delle campagne e degli assedj degl' Italiani in Spagna dal MDCCCVIII [i.e. milleottocentosette] al MDCCCXIII [i.e. milleottocentodicotto] /

Other title: Storia militare degli Italiani in Spagna.

The technical and artistic branches and ways of organizing production in Argentine soap operas

Production processes and work organization in the cultural industries have been little discussed. For this reason, the study focuses on the production phases and the division of labor in technical and artistic branches in Argentine soap operas. There are six branches: production, direction, photography, art, sound and edition. We explain the branches, the workers involved and their function and activities. This research is based on a communicational perspective, the Political Economy of Communication and recovers contributions of the Sociology of Labour. From this combination, we attempt to provide elements of analysis to understand the functioning and organisation of daily television series. In the same way, we examine the creative work, the types of work redundant or random, the division of labour and the economies of time. The methodological approach is qualitative. In this way, the examination is based on the production of interviews with key actors of the sector and the documentary and bibliographical survey so as to systematize the data for the research.