996 resultados para CM chondrites
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BACKGROUND Most guidelines recommend at least 2-cm excision margin for melanomas thicker than 2 mm. OBJECTIVE We evaluated whether 1- or 2-cm excision margins for melanoma (>2 mm) result in different outcomes. METHODS This is a retrospective cohort study on patients with melanomas (>2 mm) who underwent tumor excision with 1-cm (228 patients) or 2-cm (97 patients) margins to investigate presence of local recurrences, locoregional and distant metastases, and disease-free and overall survival. RESULTS In all, 325 patients with mean age of 61.84 years and Breslow thickness of 4.36 mm were considered for the study with a median follow-up of 1852 days (1995-2012). There was no significant difference in the frequency of locoregional and distant metastasis between the 2 groups (P = .311 and .571). The survival analysis showed no differences for disease-free (P = .800; hazard ratio 0.948; 95% confidence interval 0.627-1.433) and overall (P = .951; hazard ratio 1.018; 95% confidence interval 0.575-1.803) survival. LIMITATIONS The study was not prospectively randomized. CONCLUSIONS Our study did not show any significant differences in important outcome parameters such as local or distant metastases and overall survival. A prospective study testing 1- versus 2-cm excision margin is warranted.
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Lagout
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Fil: Ivars, Lorena Ángela. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras
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Fil: Lozada, María Helena.
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Fil: Ferreyra de Medrano, Edith.
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Fil: Vicente, Sonia.
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Fil: Nállim, Magdalena Ercilia.
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Fil: Romano, María Graciela.
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Fil: Zembrino, Anna.
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El volumen que reseñamos constituye las ACTAS de las XXIII Jornadas Nacionales de Literatura Francesa y Francófona que se llevaron a cabo en Mendoza, en la sede de la Facultad de Filosofía y Letras de la U.N.Cuyo, los días 27, 28 y 29 de mayo de 2010.