Dystrophin analysis using a panel of anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy.

Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, was studied in 19 patients with Xp21 disorders and in 25 individuals with non-Xp21 muscular dystrophy. Antibodies raised to seven different regions spanning most of the protein were used for immunocytochemistry. In all patients specific dystrophin staining anomalies were detected and correlated with clinical severity and also gene deletion. In patients with Becker muscular dystrophy (BMD) the anomalies detected ranged from inter- and intra-fibre variation in labelling intensity with the same antibody or several antibodies to general reduction in staining and discontinuous staining. In vitro evidence of abnormal dystrophin breakdown was observed reanalysing the muscle of patients, with BMD and not that of non-Xp21 dystrophies, after it has been stored for several months. A number of patients with DMD showed some staining but this did not represent a diagnostic problem. Based on the data presented, it was concluded that immunocytochemistry is a powerful technique in the prognostic diagnosis of Xp21 muscular dystrophies.

"I'm not a box. There's more than four sides to me." : En kvalitativ textanalys av karaktären Kurt Hummel och den homosexuella stereotypen

Arbetet består av en närläsning av karaktären Kurt Hummel i tv-serien Glee med fokus på stereotyper för homosexuella män, och hur Kurt förhåller sig till dem stereotyperna. Studien är gjord utifrån ett queerteoretiskt perspektiv och visar att Kurt i viss mån framställs stereotypt i seriens tidigare avsnitt, men att han efter hand uppvisar ett djup och komplexitet som man inte ofta ser hos homosexuella karaktärer på tv.

Delimitação do conceito de personalidade em Kurt Goldstein

Dada a relevância do tema - Personalidade - em Psicologia e apesar da incompletude das diversas teorias até hoje existentes, resolveu-se estudá-la à luz de Kurt Goldstein. A escolha deste autor se deve a seu trabalho metodológico tanto quanto ao fato de ser ele desconhecido dentro do saber psicológico. Esta dissertação é de cunho teórico, embora se reconheça as limitações de só atuar em teoria. Conjuntamente à obra de Goldstein o conceito foi examinado dentro dos pressupostos gestálticos, tendo sido ele observado também fenomenologiacamente, ao nível da teoria dos sistemas, da filosofia e da abordagem holista no interior de um esquema interdisciplinar. A tentativa é de aproximar um modelo proposto por Goldstein. Conclui-se ser a personalidade um processo ininterrupto e em atividade constante. Funciona em favor da unidade organísmica dentro d'um tempo que lhe configura. Expressa-se em comportamentos privilegiados sendo representada mas n'uma representação de constituição pela linguagem. Faz parte da Personalidade interligar-se, manter relações e permanecer sempre inacabada.

CHROMOSOME-STUDIES IN MALES AFFECTED BY DUCHENNE OR BECKER MUSCULAR-DYSTROPHY

We studied cytogenetically 48 male patients with Duchenne or Becker muscular dystrophy. All of them showed normal X chromosomes. Fragility of Xp21 was investigated in 1400 G-banded chromosomes of 28 patients and only one break was observed at this band (0.07%). This low frequency of breakage excludes Xp21 as a fragile site in these patients.

A crítica política e literária de Kurt Tucholsky e o início da República de Weimar (1919-1924)

Pós-graduação em Letras - FCLAS

Alignment of the CMS tracker with LHC and cosmic ray data

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Description and performance of track and primary-vertex reconstruction with the CMS tracker

A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For t (t) over bar events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p(T) > 0.9GeV is 94% for pseudorapidities of vertical bar eta vertical bar < 0.9 and 85% for 0.9 < vertical bar eta vertical bar < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p(T) = 100GeV emitted at vertical bar eta vertical bar < 1.4, the resolutions are approximately 2.8% in p(T), and respectively, 10 m m and 30 mu m in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10-12 mu m in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung.

Avaliação da migração de nifas de Scaptocoris carvalhoi Becker, 1967 (Hemiptera, Cydnidae) em plantas de importância econômica e invasora em teste com oportunidade de escolha

One of the factors that affect the control of brown - roots environmental bedbug is the wide availability of plant species. Thus, this study aimed to evaluate the migration of nymphs of the brown - roots between plant species of economic importance and invasive stinkbug. Eight species of plants have been established in a set formed by eight circular PVC containers, connected symmetrically with free communication to a central circular container. The experiment was arranged in a completely randomized design and consisted of eight treatments and six replications. The test evaluations were performed on 15o , 30o , 45o and 60o days after the release of the nymphs, by counting the insects that migrated to the roots of different plants. It was observed that by the 30o day of early release nymphs, no significant differences (P < 0,05) in the choices nymph by plants. B. alata at 15 days of initial release and B. alata and grass-dictyoneura at 30 days were plants that had higher migration. All counts were carried out on 45o and 60o days, the migration of U. brizantha cv. Marandu presented significantly higher than all other species tested plants nymphs.