992 resultados para BUCHANEK, ROSEMARY LOUISE


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Halftone photographic postcard showing the Mary Louise Tea Room, in the Barker Brothers Department Store in downtown Los Angeles, California. The tea room was run by Dolla Harris, sister of C. C. Chapman.

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A birth registration for Edith Louise Cowan. The birth is dated as August 24, 1885, and the date of issue for the certificate is November 8, 1927. Place of birth, Thorold. County of Welland.

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Skeletal muscle (SKM) is the most important tissue in maintaining glucose homeostasis and impairments in this tissue leads to insulin resistance (IR). Activation of 5’ AMP-activated kinase (AMPK) is viewed as a targeted approach to counteract IR. Rosemary extract (RE) has been reported to decrease blood glucose levels but its effects on SKM are not known. We hypothesized that RE acts directly on SKM to increase glucose uptake (GU). We found an increase in GU (184±5.07% of control, p<0.001) in L6 myotubes by RE to levels similar to insulin and metformin. Carnosic acid (CA) and rosmarinic acid (RA), major polyphenols found in RE, increased GU. RE, CA, and RA significantly increased AMPK phosphorylation and their effects on GU was reduced by an AMPK inhibitor. Our study is the first to show a direct effect of RE, CA and RA on SKM GU by a mechanism that involves AMPK activation.

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Cancer cells display enhanced growth rates and a resistance to apoptosis. Lung cancer accounts for the most cancer related deaths and non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer, accounting for almost 80% of all lung cancer cases. The phytochemical rosemary extract (RE) has been reported to have anticancer effects in vitro and in vivo however, limited evidence exists regarding the effects of RE and its polyphenolic constituents carnosic acid (CA) and rosmarinic acid (RA) in lung cancer. The present study shows RE, CA and RA inhibit lung cancer cell proliferation and survival in various NSCLC cell lines and that CA and RA interact synergistically to inhibit cell proliferation. Moreover RE, CA and RA are capable of altering activation and/or expression of Akt, ERK and AMPK, signaling molecules which regulate cell proliferation and survival. RE shows potential as an anticancer agent and should be further investigated.

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Indenture of assignment of mortgage between Archibald McLachlan of St. Thomas and Nicol Kingsmill of Toronto executors under the Last Will and Testament of Lavinia Day Thomson, late of Glencairn in Niagara Township to Florence Louise Thomson of Toronto. This is in regard to Lots 113, 114 and 115 in the Township of Niagara. This was registered in the Township of Niagara on Jan. 28, 1888 – instrument no. 2342 and instrument no. 2344, Apr. 5, 1887.

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Tesis (Maestría en Artes con Acentuación en Artes Visuales) UANL, 2010.

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Pour respecter les droits d’auteur, la version électronique de ce mémoire a été dépouillée de ses documents visuels et audio-visuels. La version intégrale du mémoire a été déposée au Service de la gestion des documents et des archives de l'Université de Montréal