Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment

Doxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin.

Histologic Evaluation of the Osteoinductive Property of Autogenous Demineralized Dentin Matrix on Surgical Bone Defects in Rabbit Skulls Using Human Amniotic Membrane for Guided Bone Regeneration

The aim of this investigation was to evaluate the osteoinductive property of autogenous demineralized dentin matrix (ADDM) on experimental surgical bone defects in the parietal bone of rabbits using the guided bone regeneration (GBR) technique incorporating human amniotic membrane (HAM). Thirty-six rabbits were divided into 2 groups, HAM and ADDM+HAM. It was possible to conclude that HAM did not interfere with bone repair and was resorbed. Slices of ADDM induced direct bone formation and were incorporated by the newly formed bone tissue and remodeled. The bone defects healed faster in the ADDM+HAM group than in the group with HAM only.

Televisão e música popular na década de 60: as vozes conflitantes de José Ramos Tinhorão e Augusto de Campos

Pós-graduação em Comunicação - FAAC

Uma análise do conceito antropológico do outro na obra do escritor Augusto Emílio Zaluar

Pós-graduação em Ciências Sociais - FFC

A construção da imagem do imperador Augusto nas obras de Veléio Patérculo, Plutarco e Suetônio

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A imagem de César e Augusto: representações do ideal de princeps em Suetônio

Pós-graduação em História - FCLAS

Um filósofo na rua Erê: presença de Pascal em O amanuense Belmiro, de Cyro dos Anjos

Pós-graduação em Letras - FCLAS

O processo de aprendizagem e as epifanias em Os anjos, de Teolinda Gersão

Pós-graduação em Letras - IBILCE

Efeitos da infusão contínua de lidocaína em bezerros anestesiados pelo isofluorano: Marcelo Augusto de Araújo. -

Pós-graduação em Ciência Animal - FMVA

Poesia e composição na canção: estudo analítico dos Três Cantos de Hilda Hilst (2002) de Almeida Prado e de canções do álbum Poesia Paulista (1998) de Achille Picchi, Eduardo Guimarães Álvares e José Augusto Mannis; composição comentada da canção A Casa do Tempo Perdido (2008) de Diogo Lefèvre

Pós-graduação em Música - IA

Insensibilização de frangos de corte em atmosfera controlada na promoção do bem estar animal: Diego Augusto Bitencourt. -

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Determination of phenolic compounds and coumarins in sugar cane spirit aged in different species of wood

The identities and quantities of the phenolic compounds and coumarins in twelve samples of sugar cane spirit aged in Quercus sp., Amburana cearensis, Cariniana legalis, Castanea sativa Mill, Ocotea sp., Cotyledon orbiculata L., and Hymenaea sp. casks were determined. These compounds have a direct influence on the sensory characteristics of aged beverages; some of them are considered to be markers for the aging process. The analysis of phenolic compounds was performed by HPLC. Solid phase extraction (SPE) was also used for the determination of coumarins. The concentrations of the principal compounds extracted varied according to the species of wood. The concentrations of total phenolic compounds ranged from 0.08 for a sample stored in a 4000-L jatobá barrel for a period of six months to 40.9 mg · L−1 for a sample aged in a 50000-L oak barrel for a period of 48 months. The use of the SPE technique removed interfering compounds from the samples, thereby improving the detection of coumarin.

Claras dos anjos

Pós-graduação em Letras - IBILCE

Theodoro Augusto Ramos: um estudo comentado de sua tese de doutoramento

Pós-graduação em Educação Matemática - IGCE