Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria

The aim of this study was to assess the variation between neuropathologists in the diagnosis of common dementia syndromes when multiple published protocols are applied. Fourteen out of 18 Australian neuropathologists participated in diagnosing 20 cases (16 cases of dementia, 4 age-matched controls) using consensus diagnostic methods. Diagnostic criteria, clinical synopses and slides from multiple brain regions were sent to participants who were asked for case diagnoses. Diagnostic sensitivity, specificity, predictive value, accuracy and variability were determined using percentage agreement and kappa statistics. Using CERAD criteria, there was a high inter-rater agreement for cases with probable and definite Alzheimer's disease but low agreement for cases with possible Alzheimer's disease. Braak staging and the application of criteria for dementia with Lewy bodies also resulted in high inter-rater agreement. There was poor agreement for the diagnosis of frontotemporal dementia and for identifying small vessel disease. Participants rarely diagnosed more than one disease in any case. To improve efficiency when applying multiple diagnostic criteria, several simplifications were proposed and tested on 5 of the original 210 cases. Inter-rater reliability for the diagnosis of Alzheimer's disease and dementia with Lewy bodies significantly improved. Further development of simple and accurate methods to identify small vessel lesions and diagnose frontotemporal dementia is warranted.

Malaria vectors on Buka and Bougainville islands, Papua New Guinea

Anophelines were sampled from 82 locations oil Buka and Bougainville islands in Papua New Guinea by larval collections, carbon dioxide-baited Mosquito traps, and human biting catches. Anopheles farauti s.s. was collected in larval Surveys but infrequently in mosquito traps on both islands; on Buka Island this species was readily collected in human biting catches. Anopheles faraunti 2 was commonly collected in larval surveys on both islands however. it was not collected in either mosquito traps or human biting catches. Anopheles punctulatus was found only on Buka Island, where it was commonly collected as larvae, but rarely in human biting catches and mosquito traps. Anopheles lungae was collected Lis larvae from only I site on Bougainville. Anopheles farauti s.s. led consistently throughout the night (1900-0600 h): small peaks at midnight and dawn were not statistically significant. Of 1,156 An. farauti s.s. specimens examined by enzyme-linked immunosorbent assay for malaria sporozoites. 20 were found to be positive: 12 were positive for Plasmodium falciparum and 8 were positive for P. vivax (247 variant = 5: 210 variant = 3). Anopheles farauti s.s. seems to be the major malaria vector on these islands, whereas An. punctulatus may play a minor role on Buka Island. Anophele farauti 2 is unlikely to be involved in malaria transmission on Buka or Bougainville islands.

Extensive multiple test centre evaluation of the VecTest malaria antigen panel assay

To determine which species and populations of Anopheles transmit malaria in any given situation, immunological assays for malaria sporozoite antigen can replace traditional microscopical examination of freshly dissected Anopheles. We developed a wicking assay for use with mosquitoes that identifies the presence or absence of specific peptide epitopes of circumsporozoite (CS) protein of Plasmodium falciparum and two strains of Plasmodium vivax (variants 210 and 247). The resulting assay (VecTest(TM) Malaria) is a rapid, one-step procedure using a 'dipstick' test strip capable of detecting and distinguishing between P. falciparum and P. vivax infections in mosquitoes. The objective of the present study was to test the efficacy, sensitivity, stability and field-user acceptability of this wicking dipstick assay. In collaboration with 16 test centres world-wide, we evaluated more than 40 000 units of this assay, comparing it to the standard CS ELISA. The 'VecTest(TM) Malaria' was found to show 92% sensitivity and 98.1% specificity, with 97.8% accuracy overall. In accelerated storage tests, the dipsticks remained stable for >15 weeks in dry conditions up to 45degreesC and in humid conditions up to 37degreesC. Evidently, this quick and easy dipstick test performs at an acceptable level of reliability and offers practical advantages for field workers needing to make rapid surveys of malaria vectors.

Pegamento e crescimento inicial de mudas de jabuticabeiras 'Açu' e 'Sabará' submetidas a dois tipos de enxertia

A jabuticabeira (Plinia sp.) pertence à família Myrtaceae e é nativa do Centro/Sul/Sudeste do Brasil. O objetivo deste trabalho foi determinar o pegamento e o crescimento inicial de mudas das jabuticabeiras 'Sabará' e 'Açu' submetidas aos métodos de enxertia de garfagem no topo em fenda cheia e garfagem no topo à inglesa simples. Foram avaliados o pegamento inicial aos 50 dias após a enxertia, o pegamento final aos 262 dias após a enxertia, o diâmetro e o comprimento da haste e o número de folhas emitidas aos 78, 107 136, 167, 199, 228 e 262 dias após a enxertia. A cultivar 'Sabará' apresentou maior pegamento inicial quando submetida ao método inglesa simples. A jabuticabeira 'Açu' obteve maior pegamento final em relação à cultivar 'Sabará'. A cultivar 'Açu' apresentou maior diâmetro, maior comprimento da haste e maior número de folhas emitidas.

Estrategias emergentes au deliberadas: um estudo de caso com os vencedores do premio "Top de Morketing" da ADYB

O presente artigo tem por objetivo principal apresentar os conceitos de estratégias emergentes e deliberadas dentro de um contexto mais amplo de marketing estratégico. A administração dessas estratégias na empresa é de extrema importância para seus objetivos. Para tanto, o método do estudo de casos foi aplicado a fim de buscar as várias dimensões pertinentes a esse tema. Como contribuição à administração estratégica nas organizações, fica a composição das estratégias emergentes e deliberadas, visando, fundamentalmente, à flexibilidade no curto prazo, com consistência no longo prazo.

Recensão de: CHARLOT, Bernard (1999). Le Rapport au Savoir en milieu populaire. Une recherche dans les Lycées Professionnels de banlieue. Paris: Anthropos, 390 p.

Revista Lusófona de Educação

La social stock exchange au Portugal: un nouvel allié de l'économie sociale

Résumé Cet article vise à contribuer à la connaissance de la Bolsa de Valores Sociais (BVS) — Social Stock Exchange — récemment créé au Portugal, dont le but primatial était de permettre la prise de moyens de financement des entités de l'Économie Sociale engagées dans des projets d'éducation et d'entreprenariat. Il se penchera sur la qualification juridique des divers types d'entités cotées dans la BVS, sur le concept d'investisseur social et sur la protection dont il jouira, vis-à-vis des exigences de transparence et de gouvernance qui incombent à ces entités. Le thème proposé sera examiné en soulignant les virtualités et le potentiel de la BVS, faisant référence à l'un ou à l'autre sujet qui viennent à effet, avec un accent particulier sur l'avantage d'élaborer un code de gouvernance corporative pour les entités de l'Économie Sociale. Abstract This article aims to contribute to the knowledge of the Bolsa de Valores Sociais (BVS) — Social Stock Exchange — recently created in Portugal, whose primatial purpose was to allow the taking of means of financing the Social Economy entities, engaged in projects in education and entrepreneurship. It will reflect on the legal classification of the various types of entities rated in the BVS, on the concept of social investor and on the protection he will enjoy, leading to the consequent demands for transparency and governance that falls upon those entities. The proposed theme will be discussed highlighting the virtues and potential of BVS, playing in one or two topics that comes to purpose, with particular emphasis on the relevance of drawing up a code of corporate governance for entities of the Social Economy. Resumen Este artículo tiene como objetivo contribuir al conocimiento de la Bolsa de Valores Sociales (BVS), recientemente creada en Portugal, cuya finalidad principal es que las entidades de la economía social dedicadas a proyectos en las áreas de educación y de iniciativa empresarial puedan obtener medios financieros. Se abordará la calificación jurídica de los diversos tipos de entidades que cotizan en la BVS, así como el concepto de inversor social y la protección de que éste goza, con las consiguientes exigencias en materia de transparencia y de gobierno que recaen sobre esas entidades. Se analizará la temática propuesta destacando las virtudes y potencialidades de la BVS, sin omitir algún otro tópico adyacente que resulte relevante, en especial la conveniencia de que sea elaborado un código de gobernanza corporativa para las entidades de la economía social.

Structural and optical studies of Au doped titanium oxide films

Thin films of TiO2 were doped with Au by ion implantation and in situ during the deposition. The films were grown by reactive magnetron sputtering and deposited in silicon and glass substrates at a temperature around 150 degrees C. The undoped films were implanted with Au fiuences in the range of 5 x 10(15) Au/cm(2)-1 x 10(17) Au/cm(2) with a energy of 150 keV. At a fluence of 5 x 10(16) Au/cm(2) the formation of Au nanoclusters in the films is observed during the implantation at room temperature. The clustering process starts to occur during the implantation where XRD estimates the presence of 3-5 nm precipitates. After annealing in a reducing atmosphere, the small precipitates coalesce into larger ones following an Ostwald ripening mechanism. In situ XRD studies reveal that Au atoms start to coalesce at 350 degrees C, reaching the precipitates dimensions larger than 40 nm at 600 degrees C. Annealing above 700 degrees C promotes drastic changes in the Au profile of in situ doped films with the formation of two Au rich regions at the interface and surface respectively. The optical properties reveal the presence of a broad band centered at 550 nm related to the plasmon resonance of gold particles visible in AFM maps. (C) 2011 Elsevier B.V. All rights reserved.

Pratiques d’enseignement en lecture-écriture et apprentissages des élèves au début du primaire

Esta investigação pretende contribuir para o desenvolvimento da investigação interessada nas questões relativas ao ensino/ aprendizagem do modo escrito nos primeiros anos do primeiro ciclo do ensino básico, particularmente tendo em conta as práticas mais propensas a apoiar a aprendizagem bem-sucedida da leitura e de escrita. Especificamente, esta investigação tem como objetivo descrever as práticas de ensino observadas nas áreas da leitura e da escrita com 22 professores, mas também para relacionar essas práticas observadas com o desempenho em leitura e escrita dos seus alunos do primeiro e do segundo ano. Globalmente, os resultados indicam que as práticas observadas, tanto do ponto de vista dos Dispositivos mobilizados como do conteúdo ensinado, são variadas e contribuem para uma visão complexa da entrada na escrita. As análises de correlação sugerem que determinadas práticas, que geralmente procuram a participação activa das crianças e as interações com os outros, estão relacionados com o progresso dos alunos durante o ano letivo.

Modèles animaux pour l’évaluation préclinique des dispositifs médicaux en radiologie interventionnelle au CR21 AP-HP INRA

Dissertação de Mestrado, Engenharia Zootécnica, 14 de Maio de 2015, Universidade dos Açores.

Le crayon et le clavier pour écrire au préscolaire et en première anneée

Plusieurs études se sont intéressées à l’utilisation de l’ordinateur comme outil pédagogique pour améliorer la compétence à écrire des élèves de même qu’aux productions écrites et aux préoccupations des élèves lorsqu’ils écrivent avec le crayon. Cependant, peu de chercheurs ont comparé ces deux modes d’écriture lors de l’entrée dans l’écrit. On peut donc se demander si les performances en orthographe et les justifications orthographiques de scripteurs débutants seront les mêmes avec le crayon et avec le clavier. On peut également se questionner sur les difficultés qu’ils rencontrent avec les deux outils d’écriture. Cet article présente une étude exploratoire qui a été menée auprès d’élèves de maternelle (5-6 ans) et de première année (6-7 ans). Les enfants ont été rencontrés individuellement pour réaliser une tâche d’écriture avec le crayon et la même tâche avec le clavier de l’ordinateur. Ensuite, les enfants ont été questionnés sur les deux outils d’écriture. Les résultats font ressortir des performances similaires avec les deux outils d’écriture, mais les justifications données par les élèves viennent moduler ces résultats, et une préférence pour l’utilisation du clavier apparaît malgré certaines difficultés.

Éssai de synthèse paléogéographique et paléobiostratigraphique du bassin occidental portugais au cours du crétacé supérieur

The Upper-Cretaceous transgressive serie is described by the authors, on the whole Occidental Portuguese Basin: it begins in the Lisbon region in the Albian and finishes in the Beira litoral province in the lower Turonian, while the sedimentation zones migrate Northward. The lithologic composition is given for each stage and sub-stage, taking into cgnsideration, in particular in the Upper Cenomanian, the lateral variations from one region to another. The paleogeography becomes clear by the study of the sedimentation environments (6 fig.). In conclusion, the authors propose a correlation between the whole serie and the accepted zonation of the Northwestern Europe. Tables show the repartition of the main macrofauna and microfauna.

Paralophiodon cf. leptorhynchum (tapiroidea, mammalia) à Vale Furado: contribution à la connaissance de l’éocène au Portugal

A canine tooth from Vale Furado is classified as Paralophiodon cf. leptorhynchum. The genus Paralophiodon indicates an age from Lower Lutetian to Auversian, Middle Eocene. As it belongs in the lineage of P. leptorhynchum, possible age span is furth~L~uced from Middle Lutetian to Auversian. This conclusion remains valid or nearly so even in the less probable case of confusion with some form included in P. isselensis lineage. Our previous (1975) datation for sandstones and pelites from Vale Furado is thus confirmed, and more accurately recognized. Paralophiodon and the crocodilian Iberosuchus are a rather sound basis for correlation with stratigraphical units near Zamora and Salamanca in Spain.

Anoplotherium (mammalia, artiodactyla) et geochelone (reptilia, testudines) à côja: les vertebras fossils et l’éocène supérieur au Portugal

A mammal (Anoplotherium cf. commune) and a land tortoise (Geochelone is. gen.] sp.) from the Ludian (Uppermost Eocene) locality of Côja have been identified. Age can be more accurately established now, from level 3 to level 5 in the Ludian stage, probably 4. Relationships between Côja's feldspathic sands, a correlative unit «Arenitos de Vale Furado», and the paroxysmal phase of pyrenean orogeny are confirmed.