Platelet Recruitment during Multiple Donor Platelet Apheresis Differs between Cell Separators

SUMMARY: BACKGROUND: Recruitment of platelets (PLT) during donor PLT apheresis may facilitate the harvest of multiple units within a single donation. METHODS: We compared two PLT apheresis procedures (Amicus and Trima Accel) in a prospective, randomized, paired cross-over study in 60 donors. The 120 donations were compared for depletion of circulating PLT in the donors, PLT yields and PLT recruitment. A recruitment was defined as ratio of total PLT yield and donor PLT depletion > 1. RESULTS: Despite comparable differences of pre- and post-apheresis PLT counts (87 × 10(9)/l in Trima Accel vs. 92 × 10(9)/l in Amicus, p = 0.383), PLT yields were higher with Trima Accel (7.48 × 10(11) vs. 6.06 × 10(11), p < 0.001), corresponding to a higher PLT recruitment (1.90 vs. 1.42, p < 0.001). We observed a different increase of WBC counts after aphereses, which was more pronounced with Trima Accel than with Amicus (1.30 × 10(9)/l vs. 0.46 × 10(9)/l, p < 0.001). CONCLUSION: Both procedures induced PLT recruitment. This was higher in Trima Accel, contributing to a higher yield in spite of a comparable depletion of circulating PLT in the donors. This recruitment facilitates the harvest of multiple units within a single donation and seems to be influenced by the procedure utilized. The different increases of circulating donor white blood cells after donation need further investigation.

Effects of high-yield thrombocytapheresis on the quality of platelet products

BACKGROUND: The steadily increasing demands for single-donor apheresis platelet (PLT) concentrates (APCs) are a challenge to the PLT supply system. Therefore, efforts to improve plateletpheresis yield, allowing apheresis products to be split into 2 or more units, are valuable strategies. No data to demonstrate in vivo transfusion efficacy of these high-yield split-APCs are currently available, however. STUDY DESIGN AND METHODS: The transfusion efficacy of APCs produced by two apheresis methods involving different harvest and storing procedures and varying PLT yields was investigated. Efficacy measures were the 1-hour percent PLT recovery (PPR(1h)) and the 1-hour corrected count increment (CCI(1h)). In total, 400 APCs, produced with either an Amicus device (Baxter) and stored in PLT additive solution (T-Sol; Amicus method [AM], n = 107) or a Trima device (Gambro) and stored in plasma (Trima method [TM], n = 293), were transfused to 55 children (31 girls; median age, 9.5 years; range, 0.2-18.5 years) with thrombocytopenia due to chemotherapy or aplastic anemia (median, 4 APCs per child; range, 1-68). RESULTS: Transfusion efficacy was significantly lower for AM-APCs than for TM-APCs (median PPR(1h), 17 and 33%; median CCI(1h), 7.9 and 15.6, respectively; p < 0.001). Reduced transfusion efficacy correlated in a yield-dependent manner with high apheresis PLT yields (>/=6 x 10(11)) for AM-APCs (p < 0.001). CONCLUSION: Although in vitro validation of AM- and TM-APCs has been performed, only by evaluating transfusion efficacy in vivo did the AM turn out to be not suitable for high-yield thrombocytapheresis. This study recommends the implementation of in vivo transfusion efficacy studies for high-yield APC apheresis donations.

Finding Onesimus: Recovering the Story of a First-Century Fugitive Slave

Author: Ryan Lokkesmoe Title: Finding Onesimus: Recovering the Story of a First-Century Fugitive Slave Advisor: Pamela Eisenbaum Degree Date: August 2015 ABSTRACT This dissertation is an investigation into the experience of a first-century fugitive slave named Onesimus, who is known to us primarily through Paul’s letter to Philemon (Phlm) in the New Testament. Within this broader purpose, this project challenges a popular historical theory for Onesimus’ flight, the so-called Amicus Domini theory. This is the theory that Onesimus fled his master Philemon with the premeditated intention of seeking out the Apostle Paul as a peacemaker in a conflict Onesimus was having with Philemon. The Amicus Domini theory is accepted by many scholars, though rarely discussed in detail or examined critically. The goal of this project is to offer a more probable historical reconstruction of Onesimus’ flight – one that takes better stock of the available evidence (historical, textual, archaeological, legal, and rhetorical). This project is rooted in the sub-discipline of the Historical Critical method, though rhetorical analysis is applied as well. This study offers a translation and commentary of Phlm, as well as an examination of Paul’s rhetoric in the letter. Other sources that specifically mention Onesimus are also investigated, e.g. Colossians, ancient Christian commentators, and the subscriptions in the manuscripts. The project also examines slavery in the Ancient Mediterranean world with a view toward understanding what most slaves experienced, and especially fugitive slaves. Roman law of slavery is also discussed, as well as the estimated travel times and cost of Onesimus’ journey (whether from Colossae to Rome, Caesarea Maritima, or Ephesus). There are many factors that are problematic for the Amicus Domini theory, e.g. the duration of Onesimus’ journey, the financial cost to Philemon, and the fact that the documents typically used to support the Amicus Domini theory (Pliny’s letters to Sabinianus and the writings of Roman jurists) do not comport with the data in Phlm. This dissertation offers a modified theory for Onesimus’ predicament: Amicus Domini Ex Post Facto. Onesimus did not leave Philemon intending to seek out Paul and reconcile with Philemon, but he eventually decided to seek help long after the fact. This historical reconstruction makes better sense of the evidence, and provides a clearer view of what Onesimus faced during his flight.

Original and miscellaneous essays /

Attributed to Robert Ruffin Collier. Cf. Shoemaker. Wrongly attributed to Francis Walker Gilmer by Halkett & Laing.

Diogenis Laertii De vitis, dogmatibus et apophthegmatibus clarorum philosophorum libri X. Graece et latine ad fidem optimorum librorum ... recensiti ... insertis XXVI. philosophorvm figuris aere incisis ... a Paullo Daniele Longolio.

Translated by A. Traversarius. cf. Brit. mus. Catalogue.

Strictures and remarks on the Earl of Selkirk's Observations on the present state of the Highlands of Scotland, with a view of the causes and probable consequences of emigration.

Bound with: Amicus (pseud.) Eight letters on the subject of the Earl of Selkirk's pamphlet on Highland emigration. 1806.

Elementa juris canonici veteris et moderni ... : accedunt Vindiciae jurisdictionis ecclesiasticae tomus I [-II] : elementa juris canonici moderni ... /

Appendix I : Praxis ecclesiastica Curiae romanae Henrico Aburlys presbytero dictata per DD. Philippum Monaldinum in urbe Romana procuratorem anno ... MDCCXXXI, 72 p., con antep. ; Appendix II : Modus facilis inveniendi textus et titulos ex Jure canonico et civili ..., [52] p. finales, con antep.

Laurentii Amico Hispano-Regalium exercituum medici consultoris praelectio academica ...

Mode of access: Internet.

The utility of ardent spirits. An address for an anti-temperance society.

Mode of access: Internet.

Remarks on the observations made on the discipline of the Quakers, by the Monthly Reviewers in their examination of William Rathbone's Narrative and memoir /

Remarks on the observations "signed": Amicus [pseud]; "postscript" signed: Philo [pseud.]

Historia reformationis ecclesiarum Raeticarum.

Mode of access: Internet.

Munimenta academica; or, Documents illustrative of academical life and studies at Oxford,

pt. 1. Libri cancellarii et procuratorum -- pt. 2. Libri cancellarii et procuratorum, accedunt acta curiae cancellarii et memoranda ex registris nonnulla.