Seedling establishment after prescribed burning of a Clear-Cut and Partially Cut mesic boreal forest in Southern Finland

Summary

Aika, gerontologia ja vanheminen

Kirjoitus perustuu III Gerontologian päivillä 30.1.1998 pidettyyn esitelmään

FOXC2 and NFATc1 control formation and maturation of collecting lymphatic vessels

The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide a molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process. We further identify transcription factor NFATc1 as a novel regulator of lymphatic development and describe a previously unsuspected link between NFATc1 and Foxc2 in the regulation of lymphatic maturation. We also provide a genome-wide map of FOXC2-binding sites in lymphatic endothelial cells, identify a novel consensus FOXC2 sequence, and show that NFATc1 physically interacts with FOXC2-binding enhancers. These data provide novel insights into the molecular program of lymphatic vascular specification and suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention.

Kansanedustajaksi rekrytoituminen ja vaalimenestykseen vaikuttavat tekijät : tapaustutkimus vuoden 1999 eduskuntavaaleista Pirkanmaan vaalipiiristä

Abstract: Recruitment of MP's and determination of electoral success

Yellow-flowered lucerne : properties and influence on performance and reproduction of ewes

Selostus: Sirppimailanen astutettavien uuhien ruokinnassa