[Archives de la Parole]. , El Phahas ; Aïta Gmaria / Maâllem Ali El Kdioui, ghaïtas [acc. perc.]

[Traditions. Afrique du Nord. Maroc]

[Archives de la Parole]. , Baïtan Hemdan ; Moual Resd Eddil / Mohamed Ben Hadj, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

[Archives de la Parole]. , Haïdous ; Ors : mariage / Maâllem Ali El Kdioui, ghaïtas [acc. perc.]

[Traditions. Afrique du Nord. Maroc]

Naächequ lebnats : [Naʿšaq al-bn̄at] ; Marcha Djezireïa : [Marša Gazā iriyya] / Marie Soussan, chant [acc. orch.]. ; Edmond N. Yafil, dir.

[Traditions. Afrique du Nord. Algérie]

Adjouadi hadi : chant du Sud Oranais / par Chikh Hammada, chant [acc. instr.]

[Traditions. Afrique du Nord. Algérie]

L'Aaroussa : en chleuh ; Moual el bafdani ; L'Aaroussa : en chleuh / troupe Bni Mtir ou Zaïane ; acc. choeurs et tahrija

[Traditions. Afrique du Nord. Maroc]

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy.

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol (ALP), on cardiac dysfunction, oxidative-nitrosative stress, apoptosis, poly(ADP-ribose) polymerase (PARP) activity and fibrosis associated with diabetic cardiomyopathy in mice. Diabetes was induced in C57/BL6 mice by injection of streptozotocin. Control and diabetic animals were treated with ALP or placebo. Left ventricular systolic and diastolic functions were measured by pressure-volume system 10 weeks after established diabetes. Myocardial XO, p22(phox), p40(phox), p47(phox), gp91(phox), iNOS, eNOS mRNA and/or protein levels, ROS and nitrotyrosine (NT) formation, caspase3/7 and PARP activity, chromatin fragmentation and various markers of fibrosis (collagen-1, TGF-beta, CTGF, fibronectin) were measured using molecular biology and biochemistry methods or immunohistochemistry. Diabetes was characterized by increased myocardial, liver and serum XO activity (but not expression), increased myocardial ROS generation, p22(phox), p40(phox), p47(phox), p91(phox) mRNA expression, iNOS (but not eNOS) expression, NT generation, caspase 3/7 and PARP activity/expression, chromatin fragmentation and fibrosis (enhanced accumulation of collagen, TGF-beta, CTGF and fibronectin), and declined systolic and diastolic myocardial performance. ALP attenuated the diabetes-induced increased myocardial, liver and serum XO activity, myocardial ROS, NT generation, iNOS expression, apoptosis, PARP activity and fibrosis, which were accompanied by improved systolic (measured by the evaluation of both load-dependent and independent indices of myocardial contractility) and diastolic performance of the hearts of treated diabetic animals. Thus, XO inhibition with ALP improves type 1 diabetes-induced cardiac dysfunction by decreasing oxidative/nitrosative stress and fibrosis, which may have important clinical implications for the treatment and prevention of diabetic cardiomyopathy and vascular dysfunction.

NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats.

Then, the expression of angiogenesis markers (western blotting), the formation of portosystemic collaterals (radioactive microspheres) and the production of superoxide anion (lucigenin-enhanced chemiluminescence) were determined. Mean arterial pressure, portal pressure, and superior mesenteric arterial blood flow and resistance were also measured.Results: In portal hypertensive rats, NAD(P)H oxidase blockade significantly decreased portosystemic collateral formation, and superior mesenteric arterial flow. It also reduced the splanchnic expression of VEGF, VEGF receptor-2 and CD31, and attenuated the increased production of superoxide, compared with vehicle.Conclusions: NAD(P)H oxidase plays an important role in experimental portal hypertension, modulating splanchnic angiogenesis, the formation of portosystemic collaterals and the development of splanchnic hyperdynamic circulation. These results suggest that NAD(P)H oxidase may represent a new target in the treatment of portal hypertension.

Abisollan Fkiraoun Laman ; Ouahed Loucham / Rais Abdallah Enair, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Guedmioua ; Tifelt / Raïs Mohamed Mouzi, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Manaoudchi M'hlic ; Nahoua Ghouziel / Mira El Marrakchia, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Tiznit ; Allouch / Abouch Tamassit, chant [acc. voc. et perc.]

[Traditions. Afrique du Nord. Maroc]

Bsit Drad Dil ; Bsit Drad Dil (suite) / Benhaïm et Melul, duo voc. [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Dialt Frouga ; Gmasa / Moulay Ahmed, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]

Ksida Dialt El M'zouda ; Ksida Dialt Haha / Moulay Ahmed, chant [acc. instr.]

[Traditions. Afrique du Nord. Maroc]