Pacific Neogene carbonate accumulation rates

I have compiled CaCO3 mass accumulation rates (MARs) for the period 0-25 Ma for 144 Deep Sea Drilling Project and Ocean Drilling Program drill sites in the Pacific in order to investigate the history of CaCO3 burial in the world's largest ocean basin. This is the first synthesis of data since the beginning of the Ocean Drilling Program. Sedimentation rates, CaCO3 contents, and bulk density were estimated for 0.5 Myr time intervals from 0 to 14 Ma and for 1 Myr time intervals from 14 to 25 Ma using mostly data from Initial Reports volumes. There is surprisingly little coherence between CaCO3 MAR time series from different Pacific regions, although regional patterns exist. A transition from high to low CaCO3 MAR from 23-20 Ma is the only event common to the entire Pacific Ocean. This event is found worldwide. The most likely cause of lowered pelagic carbonate burial is a rising sea-level trend in the early Miocene. The central and eastern equatorial Pacific is the only region with adequate drill site coverage to study carbonate compensation depth (CCD) changes in detail for the entire Neogene. The latitude-dependent decrease in CaCO3 production away from the equator is an important defining factor of the regional CCD, which shallows away from the equatorial region. Examination of latitudinal transects across the equatorial region is a useful way to separate the effects of changes in carbonate production ('productivity') from changes in bottom water chemistry ('dissolution') upon carbonate burial.

Dothidea muhlenbergiae; Dothideaceae

Dothidea muhlenbergiae Ellis

Ombrophila aurea; Leotiaceae

Ombrophila aurea Ellis

The economy of human life. Tr. from an Indian manuscript,

Authorship attributed also to the Earl of Chesterfield. cf. Notes and queries, 1st ser., v. 10 p. 8, 74, 318.

The economy of human life,

Authorship of pt. 2 attributed also to John Hill. Cf. Dict. Nat. Biog.

Jenaische Zeitschrift für Medizin und Naturwissenschaft

Includes the "Sitzungsberichte der Jenaische Gesellschaft für Medicin- und Naturwissenschaft"; 1877 bound with v. 12, 1878-86 supplements to v. 13-20, 1914-31 in v. 51-64; and the "Jahresbericht der Medizinisch-naturwissenschaftlichen Gesellschaft zu Jena", 1884-85, 1887, 1893-1938, in v. 18 suppl.-v. 19, suppl., v. 22, v. 28-33, 35, 37-39, 42-43, 46-48, 50, 52-72

The human papillomavirus type 16 E7 protein binds human interferon regulatory factor-9 via a novel PEST domain required for transformation

It is critical that viruses are able to avoid the antiviral activities of interferon (IFN). We have shown previously that the human papillomavirus (HPV) is able to avoid IFN-alpha via interaction of the HPV-16 E7 protein with IFN regulatory factor-9 (IRF-9). Here, we investigated the details of the interaction using HPV-16 E7 peptide mapping to show that IRF-9 binds HPV-16 E7 in a domain encompassing amino acids 25-36. A closer examination of this region indicates this is a novel proline, glutamate, serine, and threonine-rich (PEST) domain, with a PEST score of 8.74. We have also mapped the region of interaction within IRF-9 and found that amino acids 354-393 play an important role in binding to HPV-16 E7. This region of IRF-9 encompasses the IRF association domain (IAD), a region important for protein-protein interaction central to IRF function. Finally, we used alanine-scanning mutagenesis to determine if E7-IRF-9 interaction was important for E7-mediated cellular transformation and found that the HPV-16 E7 mutants Y25A, E26A, S31A, S32A, and E35A, but not L28A and N29A, caused loss of transformation ability. Preliminary data suggest loss of IRF-9 interaction with E7 mutants correlated with transformation. Our work suggests E7- IRF- 9 interaction is important for the transforming ability of HPV-16 E7 and that HPV-16 E7 may interact with other IRF proteins that have IAD domains.

Annotated record of the detailed examination of Mn deposits from BENTHIFACE Expedition stations

The cores described in this report were taken on the BENTHIFACE Expedition in June 1973 to July 1973 by the Scripps Institution of Oceanography from the R/V Melville. A total of 128 cores and dredges were recovered and are available at Scripps for sampling and study.