999 resultados para 1995_12200054 CTD-122 5402301
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Líderes dos partidos reunidos com o Presidente da ANC decidem que não haverá recesso. Ulysses Guimarães(PMDB-SP) diz que seria danoso para o país e para as instituições a interrupção dos trabalhos da Constituinte. Bonifácio de Andrada(PMDB-MG) também é contra a paralisação dos trabalhos. Os líderes decidiram também que a Comissão de Sistematização não aceitará emendas que mudem o sentido das propostas já apresentadas pelas comissões. Bernardo Cabral(PMDB-AM) afirma que, segundo o Regimento, só cabem emendas de adequação. Mario Covas(PMDB-SP) explica que se for alterado o Regimento Interno, permitindo a apresentação de substitutivos, corre-se o risco de uma maioria parlamentar fazer a Constituição sozinha. Brandão Monteiro(PDT-RJ) diz que há uma distorção em relação aos trabalhos na Constituinte. Na sessão O Povo Pergunta, cidadão quer saber o que os constituintes estão fazendo em termos de justiça no Brasil. Paes Landim(PFL-PI) responde que, para acelerar os processos judiciais, a Assembleia Nacional Constituinte criou a figura dos juízes distritais que participarão dos julgamentos, com a presença de populares. Iram Saraiva(PMDB-GO) apresenta projeto de decisão a Comissão de Sistematização, para que seja possível a transmissão, pelas emissoras de televisão e de rádio, das votações da Constituinte. Terminou o prazo para apresentação de emendas, tendo sido recebidas mais de 5 mil.
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Observations and laboratory experiments are summarised that examine the widely discussed issue of what Gammarus pulex feeds on. On the basis of the observations of the authors and data from the literature it can be noted that G. pulex belongs to the omnivorous organisms, but, depending on the conditions of subsistence, in its rations either plant or animal food can predominate.
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The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.
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An investigation of a commercial oxide dispersion-strengthened steel (MA9561) irradiated with high energy Ne-ions to high doses at elevated temperatures is presented. Specimens of MA956 oxide dispersion strengthened steel together with a 9% Cr ferritic/martensitic steel, e.g., Grade 92 steel were irradiated simultaneously with 20Ne-ions (with 122 MeV) to successively increasing damage levels of 1, 5 and 10 dpa at the damage peak at 440 C and 570 C, respectively. Cross-sectional microstructures of the specimens were investigated with transmission electron microscopy. MA956 oxide dispersion strengthened steel showed a higher resistance to void swelling especially to void growth at the grain boundaries than the ferritic/martensitic steel, e.g., Grade 92 steel did, and thus exhibited a prominence for an application in the situation of a high He production at high temperatures. The suppression of the growth of voids especially at the grain boundaries in MA956 is ascribed to an enhanced recombination of the point defects and a trapping of Ne atoms at the interfaces of the yttrium–aluminum oxide particles and the matrix.
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BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.
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Dissertação de Mestrado, Arquitetura Paisagista, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015
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One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved local control (p = .007). Local control significantly influenced all considered endpoints, except the metastases free survival. The global rates of G3-G4 acute and late toxicity were 13.1% and 8.2%, respectively, and they were not increased by concomitant chemotherapy. Finally, concomitant chemotherapy is efficacious and safe in the treatment of T1-2N0 anal canal cancer patients and should be prospectively studied.
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Collection : Théâtre contemporain illustré ; 121e et 122e livraisons
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Fragment 2 :Col. 1 + vignette : chapitre 98 (formule pour aller chercher le bac dans le ciel). La vignette montre une divinité assise dans la barque solaire.Col. 2 + vignette : chapitre 100 (livre pour rendre parfait un bienheureux et permettre qu'il descende dans la barque de Rê avec Ceux qui sont dans sa suite). La vignette montre le défunt sur une barque solaire avec un phénix. Osiris est debout à droite de la barque.Col. 3 + vignette : chapitre 108 (formule pour connaître les bas des Occidentaux). La vignette montre le défunt en adoration devant deux divinités assises et un serpent.Fragment 1 :Col. 1 + vignette : chapitre 109 (?) (formule pour connaître les bas des Orientaux). La vignette montre une barque solaire avec une vache, une divinité à tête de faucon coiffée d'un disque solaire et du signe divin et une divinité à tête de saurien.Col. 2 : scène figurée du chapitre 110 représentant les champs de souchets dans l'au-delà.
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Servicios registrales
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Amendment to the Act of Incorporation, chapter 122 of the Long Point Company. This is put out by John I. Mackenzie, secretary, treasurer (2 printed pages), Feb. 18, 1885.