994 resultados para 198-1209B


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Kate Evans Cathcart Lindsey (1898-1975) was a Winthrop graduate (Class of 1919) and a former president of the Greenville, SC Chapter of the Winthrop Alumni Association. The Kate Evans Cathcart Lindsey Papers consist of a scrapbook and a diary relating to Mrs. Lindsey’s college days at Winthrop, as well as, correspondence and newspaper clippings pertaining to her role as the Greenville Alumni Association President. Correspondents include James P. Kinard and Shelton Phelps. The collection is a great source for information concerning student life at Winthrop (1915-1919) and of collegiate life during World War I.

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Benzimidazoles were the first broad-spectrum anthelmintics and are still in use today against gastro-intestinal nematodes of ruminants such as Haemonchus contortus. Benzimidazoles block the polymerization of nematode microtubules. However, their efficacy is jeopardized by the spread of drug-resistant parasites that carry point mutations in beta-tubulin. Here we use a novel in vitro selection-in vivo propagation protocol to breed drug-resistant H. contortus. After 8 generations of selection with thiabendazole an in vitro resistance factor of 1000 was reached that was also relevant in vivo in infected sheep. The same procedure carried out with ivermectin produced only a moderate resistance phenotype that was not apparent in sheep. Cloning and sequencing of the beta-tubulin genes from the thiabendazole-resistant H. contortus mutants revealed all of the isotype 1 alleles, and part of the isotype 2 alleles, to carry the mutation glutamate(198) to alanine (E198A). An allele-specific PCR was developed, which may be helpful in monitoring the prevalence of alanine(198) encoding alleles in the beta-tubulin isotype 1 gene pool of H. contortus in the field.

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Here, we report a case of OXA-48-producing Salmonella enterica serovar Kentucky of sequence type 198 (ST198) from perianal screening cultures of a patient transferred from Libya to Switzerland. The blaOXA-48 gene was carried by Tn1999.2 and located on an ∼60-kb IncL/M plasmid. This Salmonella strain also possessed the blaVEB-8, aac(6)-Ib, tet(A), sul1, and mphA resistance genes and substitutions in GyrA (Ser83Phe and Asp87Asn) and ParC (Ser80Ile). This finding emphasizes that prompt screening strategies are essential to prevent the dissemination of carbapenemase producers imported from countries where they are endemic.

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Vorbesitzer: Dominikanerkloster Frankfurt am Main

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Kondolation zum Tode Marie Stoltzes, Einladung zu einem Besuch

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1 Brief von Frederick Pollock an Thomas Mann, 13.12.1943; 1 Brief von John Slawson an Frederick Pollock, 29.11.1943; 1 Brief von Ernst Simmel an Frederick Pollock, 14.10.1943; 1 Brief von Edith Kriss an Margot von Mendelssohn, 13.10.1943; 1 Brief von Margot von Mendelssohn an Max Horkheimer, 23.01.1944;

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Vorbesitzer: Heinrich Anton Cornill-d'Orville (Exlibris im Vorderdeckel)

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The Cretaceous has long been recognized as a time when greenhouse conditions were fueled by elevated atmospheric CO2 and accompanied by perturbations of the global carbon cycle described as oceanic anoxic events (OAEs). Yet, the magnitude and frequency of temperature change during this interval of warm and equable climate are poorly constrained. Here we present a high-resolution record of sea-surface temperatures (SSTs) reconstructed using the TEX86 paleothermometer for a sequence of early Aptian organic-rich sediments deposited during the first Cretaceous OAE (OAE1a) at Shatsky Rise in the tropical Pacific. SSTs range from ~30 to ~36 °C and include two prominent cooling episodes of ~4 °C. The cooler temperatures reflect significant temperature instability in the tropics likely triggered by changes in carbon cycling induced by enhanced burial of organic matter. SST instability recorded during the early Aptian in the Pacific is comparable to that reported for the late Albian-early Cenomanian in the Atlantic, suggesting that such climate perturbations may have recurred during the Cretaceous with concomitant consequences for biota and the marine environment.

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