A non-interventional phase IV Belgian survey to assess the antiviral effectiveness of pegylated interferon-alpha-2b and ribavirin treatment according to the stage of liver fibrosis in previously untreated patients with genotype 1/4/5/6 chronic hepatitis C (PRACTICE).

BACKGROUND AND STUDY AIMS: This was an observational, non-interventional, multicenter, phase IV study, in patients with genotype 1/4/5/6 chronic hepatitis C (CHC). The primary objectives were to evaluate SVR in patients with no or minimal fibrosis (METAVIR F0-F1) versus well established fibrosis (F2-F4), and to estimate response on Weeks 12, 24 and 48 on treatment in previously untreated patients with genotypes 1/4/5/6 CHC. PATIENTS AND METHODS: 538 patients treated with pegylated interferon alfa 2b 1.5 mcg/kg in combination with ribavirin 800-1200 mg/day were enrolled in 55 sites in Belgium and Luxembourg, 505 being considered for the analysis. 40% of the patients were female and 60% male, the average age was 47.5 years, 10.5% were 65 or older. RESULTS: SVR was observed in 35% of the patients, EVR in 68%, of which pEVR in 33% and cEVR in 35%. SVR was observed in 43% of the low fibrosis group (F0, F1) and 30% of the high fibrosis group (F2, F3, F4) (p = 0.005). SVR rates were 34% for genotype 1, 37% for genotype 4, and 47% for genotype 5 (NS). Multivariate analysis showed that EVR and baseline METAVIR score are independent prognostic factors for SVR. CONCLUSIONS: This trial confirms that fibrosis stage and early viral response are the most important key-factors to predict sustained response, suggesting that the earlier patients are treated, the better the outcome. Non-invasive techniques enable us to closely monitor progression of fibrosis, allowing a better selection of patients for antiviral treatment in the DAA-era.

[Tasavallan Presidentin vierailu Yhdysvaltoihin 1.8.-5.8.1976] (Tasavallan Presidentin vastaus Presidentti Fordille Valkoisen Talon nurmikolla pidettyjen tervetuliaisseremonioiden yhteydess�� 3.8.1976)

Puhe

Elektronisten julkaisujen identifiointi : versio 1.0 5.5.1998

Tallenteen alussa huomautus: Artikkelin uusin versio osoitteessa http://www.lib.helsinki.fi/meta/id.html.

Healthy Aging Update, August 1, 2006, Vol. 1, no. 5

This bimonthly electronic newsletter will provide information and resources on nutrition and health promotion and disease prevention. The Healthy Aging Update is produced for informal and educational purposes only. The newsletter will be distributed electronically and posted on the Department���s website at www.state.ia.us/elderaffairs.

Immunization Update, June 2007, Vol. 1, no. 5

Monthly newsletter for the Iowa Department of Public Health

Missouri River Flood Recovery, January 27, 2012 Vol. 1, no. 5

The Missouri River Flood Recovery newsletter is published by the Iowa Homeland Security and Emergency Management Division in cooperation with members of the Missouri River Recovery Coordination Task Force.

Acreage Answers, December 2000-January 2001, Vol. 1, no. 5

Newsletter for those who reside on acreages in Iowa. Produced by the Iowa State University Extension Office.

1.�� Glossarium vetus. ��� 2.�� Ciceronis synonyma. ��� 3.�� Senecae, Publii Syri et aliorum sententiae. ��� 4.�� Eucherii, Episcopi, glossae spiritales : maxima pars desideratur. ��� 5.�� Glossae in Horatii libros carminum, epodon, de arte po��tica et epistolarum : nonnulla passim desiderantur. ��� Hujusce codicis pars decimo ; pars duodecimo saeculo videtur exarata.

Puteanus

Endeavors Update, Iowa Medicaid Enterprise, Vol. 1, Issue 5, January 27, 2011

The Iowa Medicaid Enterprise (IME) is an endeavor, started in 2005, to unite State staff with ���best of breed��� contractors into a performance-based model for administration of the Medicaid program.

Grand sonata Piano forte and Violoncello No 1 Op 5

Museokokoelma: 005.