1000 resultados para 12-111A


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“We wish you a Merry Christmas, and a Happy New Year” ... when the Christmas carols start playing in the pharmacy, it is a reminder the silly season has crept up on us. Christmas should be a time of celebration, fun and spending time with loved ones and families. However, if pharmacies are not prepared it can easily turn into the “nightmare before Christmas”. So to make sure everything runs smoothly like Santa’s schedule, we have compiled a few tips to help retailers survive and prepare for Christmas...

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Solvolysis of nine representative half ester acid chlorides in aqueous acetone have been studied. Isomers solvolyse at distinctly different rates and furnish the original acids. Contrary to the well accepted views, no evidence for tautomerism or isomerism between the isomeric pairs of acid chlorides could be detected. In a number of cases alkoxy group participates in the solvolysis of neighbouring acid chlorides. This results in (a) rate enhancement and (b) partial or total shift of the reaction pattern from SN2 to SN1. Isomeric half ester acid chlorides, in the presence of a sufficiently strong Lewis acid, could give the same oxonium salt. Rearrangements observed in the reactions of unsymmetrical 1,2- and 1,3-dicarboxylic acid derivatives could be ascribed to the prior formation of common oxonium salt intermediates in the presence of Lewis acids.

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The aim of this study was to validate a multiplex PCR for the species identification and serotyping of Actinobacillus pleuropneumoniae serovars 1, 5, 7, 12 and 15. All 15 reference strains and 411 field isolates (394 from Australia, 11 from Indonesia, five from Mexico and one from New Zealand) of A. pleuropneumoniae were tested with the multiplex PCR. The specificity of this multiplex PCR was validated on 26 non-A. pleuropneumoniae species. The multiplex PCR gave the expected results with all 15 serovar reference strains and agreed with conventional serotyping for all field isolates from serovars 1 (n = 46), 5 (n = 81), 7 (n = 80), 12 (n = 16) and serovar 15 (n = 117). In addition, a species-specific product was amplified in the multiplex PCR with all 411 A. pleuropneumoniae field isolates. Of 25 nontypeable field isolates only two did not yield a serovar-specific band in the multiplex PCR. This multiplex PCR for serovars 1, 5, 7, 12 and 15 is species specific and capable of serotyping isolates from diverse locations. Significance and Impact of the Study A multiplex PCR that can recognize serovars 1, 5, 7, 12 and 15 of A. pleuropneumoniae was developed and validated. This novel diagnostic tool will enable frontline laboratories to provide key information (the serovar) to guide targeted prevention and control programmes for porcine pleuropneumonia, a serious economic disease of pigs. The previous technology, traditional serotyping, is typically provided by specialized reference laboratories, limiting the capacity to respond to this key disease.

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Background Studies investigating the relationship between malnutrition and post-discharge mortality following acute hip fracture yield conflicting results. This study aimed to determine whether malnutrition independently predicted 12-month post-fracture mortality after adjusting for clinically relevant covariates. Methods An ethics approved, prospective, consecutive audit was undertaken for all surgically treated hip fracture inpatients admitted to a dedicated orthogeriatric unit (November 2010–October 2011). The 12-month mortality data were obtained by a dual search of the mortality registry and Queensland Health database. Malnutrition was evaluated using the Subjective Global Assessment. Demographic (age, gender, admission residence) and clinical covariates included fracture type, time to surgery, anaesthesia type, type of surgery, post-surgery time to mobilize and post-operative complications (delirium, pulmonary and deep vein thrombosis, cardiac complications, infections). The Charlson Comorbidity Index was retrospectively applied. All diagnoses were confirmed by the treating orthogeriatrician. Results A total of 322 of 346 patients were available for audit. Increased age (P = 0.004), admission from residential care (P < 0.001), Charlson Comorbidity Index (P = 0.007), malnutrition (P < 0.001), time to mobilize >48 h (P < 0.001), delirium (P = 0.003), pulmonary embolism (P = 0.029) and cardiovascular complication (P = 0.04) were associated with 12-month mortality. Logistic regression analysis demonstrated that malnutrition (odds ratio (OR) 2.4 (95% confidence interval (CI) 1.3–4.7, P = 0.007)), in addition to admission from residential care (OR 2.6 (95% CI 1.3–5.3, P = 0.005)) and pulmonary embolism (OR 11.0 (95% CI 1.5–78.7, P = 0.017)), independently predicted 12-month mortality. Conclusions Findings substantiate malnutrition as an independent predictor of 12-month mortality in a representative sample of hip fracture inpatients. Effective strategies to identify and treat malnutrition in hip fracture should be prioritized.

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Octachlorocyclotetraphosphazene, N4P4CIa, reacts with dibenzylamine to give the chloro(dibenzy1amino) derivatives, N4P,C18,[N(CH2Ph)2],,, n = 1, 2 (two isomers), and 4 (three isomers). Nongeminal structures have been assigned to these compounds on the basis of ‘H and jlP NMR spectra. The presence of at least two tris(dibenzylamin0) derivatives in some reaction mixtures is also inferred from NMR spectra. Steric effects become important at the tetrakis stage of chlorine replacement, and further substitution by dibenzylamine to give monocyclic tetrameric derivatives does not occur. A “bicyclic” phosphazene, N4P4[N(CH2Ph)2]6(NCHzPh)is, obtained from the reaction of N4P4Claw ith an excess of dibenzylamine in boiling methyl cyanide. The formation of this derivative and its spectroscopic data are discussed.

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Autuus on katsojan silmässä: lukijakeskeinen tutkimus autuaaksijulistuksista Matt. 5 : 1-12 on reseptioanalyyttisellä metodilla tehty tutkimus siitä, miten akateeminen tutkimuskirjallisuus ja kymmenen valikoitua Jeesus-elokuvaa ovat ymmärtäneet autuaaksijulistusten merkityksen. Kartoitettuaan autuaaksijulistusten tulkintahistoriaa ja Jeesus-elokuvien kulttuurihistoriaa tutkielma kääntyy reseptiohistorialliseksi analyysiksi. Akateemisen tutkimuskirjallisuuden ja Jeesus-elokuvien esittämät tulkinnat Matteuksen evankeliumin autuaaksijulistuksista rinnas-tetaan suhteessa autuaaksijulistusten tyyliin, sisältöön, rakenteeseen ja merkitykseen. Autuaaksijulistusten tyylin tulkinnan analysointi tapahtuu vertailemalla millainen narratiivinen sijainti autuaaksijulistuksille on tarinassa annettu, millaiseksi elokuvat ja tutkimuskirjallisuus tulkitsevat julistusten esitykselliset puitteet sekä mitä näkemyksiä niillä on julistusten kohdeyleisöstä ja Jeesuksen esiintymistavasta. Autuaaksijulistusten sisällön analysointi tarkoittaa yksittäisten autuaaksijulistusten merkityksen selvittelyä. Tämä tapahtuu edelleen Jeesus-elokuvien ja tutkimuskirjallisuuden tekemiä tulkintoja vertailemalla. Näiden lisäksi tekijä esittää oman käännöksensä autuaaksijulistuksista eksegeettisen analyysin keinoin. Käännöksen tavoitteena ei kuitenkaan ole sanatarkkuus, vaan dynaamisuus lukijan tulkinnan säilyttämiseksi. Autuaaksijulistusten rakenteen analysointi esittelee muutamia erilaisia malleja, joiden mukaan tutkimuskirjallisuudessa Matteuksen evankeliumin autuaaksijulistuksia on ryhmitelty. Tässä alaluvussa elokuva-aineiston ja tutkimuskirjallisuuden erot ovat selkeimmin näkyvillä, sillä elokuvat pyrkivät ryhmittelyn sijasta luomaan autuaaksijulistuksille kokonaan uuden rakenteen, joka sopii elokuvakerrontaan julistuslistaa paremmin. Autuaaksijulistusten merkitystä analysoitaessa tutkielmassa asetetaan rinnan kolme Jeesus-elokuvaa, jotka edustavat tulkintahistoriasta tuttuja tulkinnallisia pääsuuntia: autuaaksijulistukset tulkitaan joko eettisiksi kehotuksiksi tai lupauksiksi armosta. Kolmas Jeesus-elokuva edustaa kontroversiaalista näkemystä, joka kiistää molemmat edellä mainitut tulkintatavat. Johtopäätöksissä osoitetaan reseptiohistorialliseen analyysiin viitaten, että tulkintojen muotoutuminen ei ole yksinkertaista. Tulkintaan vaikuttavat paitsi tulkitsijan ennakkokäsitykset, myös tulkittava teksti ja tulkintatilanne. Johtopäätöksissä puolustetaan myös populaarikulttuurin teologisten elementtien tutkimusta osana eksegetiikkaa.