Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.

Quantification of Myocardial Blood Flow in Absolute Terms Using (82)Rb PET Imaging: The RUBY-10 Study.

OBJECTIVES: The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models. BACKGROUND: It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET. METHODS: Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs. RESULTS: The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM. CONCLUSIONS: SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.

Body size and early growth in appropriate- and large-for-gestational-age infants.

AIMS: To study weight, length, body composition, sleeping energy expenditure (SEE), and respiratory quotient (RQ) at birth and at 5 mo of age in both adequate-for-gestational-age (AGA) and large-for-gestational-age (LGA) subjects; to compare the changes in body weight and body composition adjusting for gender, age, SEE, RQ and several maternal factors; to investigate the contribution of initial SEE and RQ to changes in body weight and body composition. METHODS: Sixty-nine neonates were recruited among term infants in the University Hospital of Verona, Italy. Forty-nine subjects participated until follow-up. At birth and follow-up, weight and length were measured and arm-fat area and arm-muscle area were calculated from triceps and subscapular skinfolds. SEE and RQ were measured by indirect calorimetry. RESULTS: At birth, weight, length, arm-muscle and arm-fat areas were significantly higher in LGA subjects than in AGA subjects. Weight status, SEE and RQ at birth did not explain the relative weight change after adjusting for gestational weight, placental weight, age at follow-up and gender. Arm-fat area and weight/length ratio at birth were negatively associated with relative changes in body weight after adjusting for the above variables (p < 0.05). CONCLUSION: Early growth from birth to 5 mo of life is significantly affected by body size and adiposity at birth. Fatter newborns had a slower growth rate than thinner newborns.

Om demanters rätta art och beskaffenhet

Invocatio: M.G.H.

L'Univers

1870/06/09 (Numéro 1127).

Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease

Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyridostigmine bromide (PYR), a reversible anticholinesterase agent, on the electrocardiographic variables, particularly QTc interval, in patients with stable coronary artery disease. In a randomized double-blind crossover placebo-controlled study, simultaneous 12-lead electrocardiographic tracings were obtained at rest from 10 patients with exercise-induced myocardial ischemia before and 2 h after the oral administration of 45 mg PYR or placebo. PYR increased the RR intervals (pre: 921 ± 27 ms vs post: 1127 ± 37 ms; P<0.01) and, in contrast with placebo, decreased the QTc interval (pre: 401 ± 3 ms vs post: 382 ± 3 ms; P<0.01). No other electrocardiographic variables were modified (PR segment, QT interval, QT and QTc dispersions). Cholinergic stimulation with PYR caused bradycardia and reduced the QTc interval without important side effects in patients with coronary disease. These effects, if confirmed in studies over longer periods of administration, may suggest a cardioprotection by cholinergic stimulation with PYR.

Relationship between Daily Habits, Oral Microbiota and Caries with Special Reference to Xylitol

Caries is a plaque-associated multifactorial chronic disease. Oral hygiene habits, sugar, and oral micobiota interactions are important for caries to occur. Xylitol has been shown to reduce caries mainly due to its effects on mutans streptococci (MS). The purpose of this study was to evaluate the relationship of daily oral health habits and bacterial level on the caries occurrence and to study the effect of xylitol on the composition of oral microflora. A total of 192, 10-12 years old, male school children had been screened for salivary MS. Healthy subjects with high MS counts participated in two parallel double-blinded, randomised, controlled trials. In the first 5-week trial, subjects were assigned into xylitol (n=35) and sorbitol gum (n=38) groups. At baseline, children were examined using International Caries Detection and Assessment System (ICDAS) criteria and interviewed for oral health habits. In the second 4-week trial, subjects were assigned into xylitol (n=25) and saccharine mouthrinse (n=25) groups. In the end of both interventions, saliva samples were collected. The samples were analysed for changes in MS counts and changes in the composition of the oral microbiota assessed by the Human Oral Microbe Identification Microarray (HOMIM). Relationships between daily habits, bacterial levels and caries were evaluated. Daily use of sweets and soft drinks were the habits significantly associated with caries severity measured by ICDAS Caries Index (CI), while toothbrushing was the only habit associated with the low caries severity. Abiotrophia defectiva and Actinomyces meyeri/ A. odontolyticus were significantly higher in caries-affected children while Shuttleworthia satelles was significantly higher in caries-free children. Xylitol showed significant reduction in salivary levels of MS in both trials. No significant effects on other members of the microbiota were found when evaluated by HOMIM. In conclusion, other members of oral microbiota than MS may be associated with caries occurrence or absence. The use of xylitol had significant effect on MS with no effects on the other members of the salivary microbiota.

Le Petit journal. Supplément du dimanche

1912/06/23 (Numéro 1127).

L'Écho de Paris

1887/04/17 (Numéro 1127).

Mélanges. — Extraits de cartulaires.

Contient : Extrait du testament d'Étienne, comte de Montbéliard ; Charte de Louis, comte de Ferrette, pour l'abbaye de Pairis ; Couronnement de Charles le Chauve à Metz (869), etc ; Donation faite par Louis de Luxembourg, comte de Saint-Pol, à Antoine Villiers de l'Isle-Adam ; Mandement de Louis XI à Jacques Villiers de l'Isle-Adam de prendre possession de la ville de Paris ; Extraits du cartulaire de Brioude ; Charte du vicomte Néel pour l'abbaye de Jumièges ; Historia Selebiensis, Eboracensis dioceseos (cf. Labbe, Bibl. Nova, I, p. 594) ; Extraits d'un obituaire de l'église du Mans ; Donation de Louis, duc de Bourbon, à la même église ; Extraits du cartulaire de Saint-Aubin d'Angers ; Généalogie des fondateurs de l'abbaye de Jouarre, d'après un martyrologe ; Notice sur les origines de Ferrières en Gâtinais ; Liste des bulles pontificales de Fontevrault ; Chartes de Vernon ; Charte de Robert, duc de Normandie, pour le monastère de Montivilliers ; Extraits de l'obituaire d'Hérivaux ; Tableau des filiales de Clairvaux ; Extraits du cartulaire d'Auberive, au diocèse de Langres ; Extraits du cartulaire de Longuay ; Extraits du cartulaire de Montiérender ; Extraits du cartulaire de l'Isle-en-Barrois ; Extraits du cartulaire de Beaulieu en Limousin ; Extraits d'un cartulaire de l'évêché de Langres ; Extraits d'un cartulaire de l'église d'Angers ; Extraits d'un cartulaire de Royaumont ; Extraits d'un registre de Saint-Merri de Paris ; Chartes d'Angers ; Extraits de l'inventaire des titres de Notre-Dame-des-Clairets ; Accord entre Robert, comte de Dreux, et l'évêque de Paris (1209 ; — il y en a une autre copie au fol. 150) ; Extraits du cartulaire de la forêt de Halatte ; Chartes de Vierzon ; Extraits du cartulaire de Massay ; Généalogie des seigneurs de Vierzon ; Diplôme de Louis d'Outre-Mer pour Saint-Merri ; Extraits des cartulaires de l'évêché de Paris ; Chartes de Grammont ; Extraits du cartulaire de Maubuisson ; Extraits de l'obituaire de Sainte-Croix d'Orléans ; Extraits du cartulaire de la chapelle de Saint-Lazare de Blois ; Extraits du cartulaire de Notre-Dame du Bourg-Moyen de Blois. [Ms. Vatic. Ottoboni 2960] ; Extrait des titres de l'abbaye de l'Étoile (de Poitiers) ; Chartes de La Merci-Dieu ; Extraits du cartulaire de Saint-Martin-des-Champs concernant les seigneurs du Puiset ; Extraits d'un cartulaire de Saint-Père de Chartres ; Extraits d'un martyrologe de l'église de Chartres ; Extraits des cartulaires de Saint-Père ; Lettre de Manassès, archevêque de Reims, à Hugues de Die ; Extrait d'un obituaire de Saint-Barthélemi de Béthune ; Charte de Baudouin V, comte de Flandre, pour l'abbaye de Marchiennes ; Échange entre l'abbaye de Saint-Vaast d'Arras et Robert, comte de Flandre ; Charte de Philippe I pour l'église Saint-Pierre d'Aire ; Charte de Hugues, châtelain de Cambrai, pour l'abbaye du Mont-Saint-Éloi ; Charte d'Enguerrand, comte de Saint-Pol, pour l'abbaye de Marchiennes ; Charte de Thierri, comte de Flandre, pour Enguerrand, comte de Saint-Pol ; Chartes d'Eaucourt en Artois ; Charte de Jean, êvêque de Thérouanne, pour l'église Saint-Pierre de Lille ; Note sur le mariage d'Isabeau de Barbazan ; Inventaire de reliques, extrait d'un processionnaire de l'église de Soissons ; Extrait d'un cartulaire du prieuré de Donchery ; Catalogue des abbés de Montiéramey ; Catalogue des abbesses de Notre-Dame-du-Lys ; Charte de Brunon, abbé de Montiéramey ; Extraits du cartulaire d'Uzerche ; Extraits de chartes de la Couture du Mans ; Extraits du cartulaire de Bonlieu en Limousin ; Notes sur la maison de Mercoeur ; Extraits d'un martyrologe de Saint-Séverin de Paris ; Extraits du cartulaire de Vendôme ; Extraits du cartulaire de Saint-Pierre de Beauvais ; Extraits du cartulaire de Saint-Rémi de Reims ; Catalogue des abbés de la Chaise-Dieu ; Extraits du cartulaire de Saint-Nicaise de Meulan ; Extraits de la chronique de Saint-Mihiel de Verdun ; Serment prêté par l'hérésiarque Bérenger ; Extraits d'obituaires du Mont-Saint-Michel ; Extraits des titres de Saint-Ulface ; Extraits du cartulaire de Saint-Vincent du Mans ; Extraits du cartulaire de Nogent-le-Rotrou ; Extrait du cartulaire de Pont-aux-Dames (de Meaux) ; Chartes du prieuré de Lavardin ; Extraits d'un cartulaire de Saint-Vincent de Laon ; Extraits du cartulaire rouge de l'église de Laon ; Chartes de Saint-Quentin près Beauvais ; Extraits du cartulaire de Vierzon ; Extraits du cartulaire de Beaulieu ; Notes sur les chartes de Subiaco ; Extraits du cartulaire de Saint-Thierry de Reims ; Extraits d'un martyrologe de Saint-Avold ; Chartes de Saint-Martin d'Épernay ; Chartes de Saint-Vincent-au-Bois ; Extraits du cartulaire de Tiron ; Extraits des archives de Saint-Bavon de Gand ; Extraits du cartulaire de Marchiennes ; Extraits des archives de Saint-Pierre de Gand ; Charte de Robert, comte de Flandre, pour l'église de Tronchiennes ; Charte de Baudouin, comte de Flandre, pour l'abbaye d'Einham ; Extraits des archives de l'évêché de Gand ; Extraits de cartulaires de Saint-Bavon ; Extraits des cartulaires et registres de Fontevrault ; Extraits des titres de Beaugerais ; Chartes de Villeloin ; Extraits d'un cartulaire de l'église d'Amiens ; Extraits du cartulaire de Clairmarais ; Titres de Saint-Bertin ; Charte de Baudouin, comte de Flandre, pour l'abbaye de Marchiennes

Recueil de chartes de commune.

Contient : Châteauvillain ; Troyes ; Nogaro en Armagnac ; Narbonne ; La Beuvrière (cf. fol. 73) ; Reims ; Troyes ; Beaumont ; Châteauvillain (1236 ; cf. fol. 2) ; La Chapelle [d'Angillon] ; Joigny ; Lorris ; Dixmont ; Montargis ; Barcelone (cf. fol. 149) ; Selens et Saint-Aubin ; La Beuvrière (cf. fol. 14) ; Chaumont ; Saint-Bris ; Saint-Laurent-sur-Barenjon ; Voisines ; Le Moulinet ; Barlieu ; Crespy [-en-Valois] ; Montdidier ; Laon ; Soissons ; Abbeville ; Compiègne ; Saint-Quentin ; Corbie ; Saint-Josse-sur-Mer ; La Fère ; Beauvais ; Nanteuil ; Courmelles ; Breteuil ; Beaumont-en-Argonne ; Chaumont ; Saint-Omer ; Vaux près Mouzon ; Vaux, Saconin, Mercin ; Chacrise ; Tournai ; Crandelain, etc ; Ambleteuse ; Morsain, etc ; Mantes ; Ferrières ; Aizy ; Pargny ; Saint-Riquier ; Soissons ; Saint-Martin d'Issoudun (cf. fol. 182) ; Rouen ; Dreux ; Meaux ; Reims ; Chablis ; Chatillon-sur-Seine ; Sens ; Auxerre ; Cerny ; Dixmont ; Étampes ; Orléans ; Bourges ; Issoudun (cf. fol. 148) ; Beaufort-en-Vallée ; La Rochelle ; Villefranche [d'Allier] ; Montauban ; Nevers ; Castres ; Toulouse ; Habitants de la Terre d'Albigeois ; Aigues-Mortes ; Lorrez-le-Bocage ; Le Puy ; Saint-Céré ; Barcelone ; Chatillon-sur-Marne ; Raucourt et Héraucourt ; Mézières ; Chatillon-sur-Marne ; Saint-Hellier ; Coutumes d'Anjou et du Maine ; Ervy-le-Chatel ; Cerres, Montceaux, Chaussepierre ; Notice sur un ms. de Chroniques françaises, de la bibliothèque de Colbert (= Duchesne 79)