Ulrike Meinhofin tie terroristiksi: kaupunkisissitaktiikka poliittisen intervention välineenä

Abstract: Ulrike Meinhof's way to terrorism: the urban guerilla tactics as a means of political intervention

Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy.

BACKGROUND & AIMS: Vitamin D is an important immune modulator and preliminary data indicated an association between vitamin D deficiency and sustained virologic response (SVR) rates in hepatitis C virus (HCV) genotype 1 patients. We, therefore, performed a comprehensive analysis on the impact of vitamin D serum levels and of genetic polymorphisms with functional relevance within the vitamin D cascade on chronic hepatitis C and its treatment. METHODS: Vitamin D serum levels, genetic polymorphisms within the vitamin D receptor and 1α-hydroxylase were determined in a cohort of 468 HCV genotype 1, 2, and 3 infected patients who were treated with interferon-alfa based regimens. RESULTS: Chronic hepatitis C was associated with a high incidence of severe vitamin D deficiency compared to controls (25(OH)D(3)<10 ng/ml in 25% versus 12%, p<0.00001). 25(OH)D(3) deficiency correlated with SVR in HCV genotype 2 and 3 patients (50% and 81% SVR for patients with and without severe vitamin D deficiency, respectively, p<0.0001). In addition, the CYP27B1-1260 promoter polymorphism rs10877012 had substantial impact on 1,25-dihydroxyvitamin D serum levels (72, 61, and 60 pmol/ml for rs10877012 AA, AC, and CC, respectively, p=0.04) and on SVR rates in HCV genotype 1, 2, and 3 infected patients (77% and 65% versus 42% for rs10877012 AA, AC, and CC, respectively, p=0.02). CONCLUSIONS: Chronic hepatitis C virus infection is associated with vitamin D deficiency. Reduced 25-hydroxyvitamin D levels and CYP27B1-1260 promoter polymorphism leading to reduced 1,25-dihydroxyvitamin D levels are associated with failure to achieve SVR in HCV genotype 1, 2, and 3 infected patients.

Cell-mediated immunity to predict cytomegalovirus disease in high-risk solid organ transplant recipients.

Late-onset cytomegalovirus (CMV) disease commonly occurs after discontinuation of antiviral prophylaxis. We determined the utility of testing CD8+ T-cell response against CMV as a predictor of late-onset CMV disease after a standard course of antiviral prophylaxis. Transplant patients at high-risk for CMV disease were enrolled. CD8+ T-cell-mediated immunity (CMI) was tested using the QuantiFERON-CMV assay at baseline, 1, 2 and 3 months posttransplant by measurement of interferon-gamma response to whole blood stimulation with a 21-peptide pool. The primary outcome was the ability of CMI testing to predict CMV disease in the first 6 months posttransplant. There were 108 evaluable patients (D+/R+ n = 39; D-/R+ n = 34; D+/R- n = 35) of whom 18 (16.7%) developed symptomatic CMV disease. At the end of prophylaxis, CMI was detectable in 38/108 (35.2%) patients (cutoff 0.1 IU/mL interferon-gamma). CMV disease occurred in 2/38 (5.3%) patients with a detectable interferon-gamma response versus 16/70 (22.9%) patients with a negative response; p = 0.038. In the subgroup of D+/R- patients, CMV disease occurred in 1/10 (10.0%) patients with a detectable interferon-gamma response (cutoff 0.1 IU/mL) versus 10/25 (40.0%) patients with a negative CMI, p = 0.12. Monitoring of CMI may be useful for predicting late-onset CMV disease.

anonymi tractatus de magia, sive de philosophia naturali, in quo praesertim de astrologia judiciaria disseritur.

Colbertinus

Francisci Maurolyci, Siculi, demonstratio algebrae ; sive potiùs, regulae calculi litteralis ad inveniendum terminum quemlibet proportionis geometricè continuae.

Colbertinus

Euclidis elementorum libri decem priores, à Francisco Maurolyco in epitomen contracti.

Colbertinus

1.° Francisci Maurolyci demonstrationes in duodecimum librum Euclidis elementorum. — 2.° Ejusdem modus fabricandi astrolabium, cum demonstrationibus geometricis. — 3.° Ejusdem opusculum de fabrica et usu quadrati horarii, ad omnem horisontem accommodati. — 4.° Collectanea ex fabula et historia antiqua.

Colbertinus

1.° Sereni cylindricorum libri duo : Francisco Maurolyco interprete. — 2.° Archimedis libellus de circuli dimensione : eodem Maurolyco interprete.

Colbertinus

1.° Francisci Maurolyci de centro solidi parabolae demonstratio : praemittuntur catalogus ejusdem operum et observationes de ordine quo singula legenda sunt. — 2.° Descriptio hyperbolarum contrapositarum, diametrorum, tangentium, linearum continuè proportionalium et triangulorum aequalium : authore eodem. — 3.° Ejusdem algebra, sive potiùs, regulae calculi litteralis ad inveniendum terminum quemlibet proportionis geometricè continuae.

Colbertinus

1.° Theonis, ex traditione Pappi, datorum libri duo : interprete Francisco Maurolyco ; cum ejusdem Maurolyci additionibus. — 2.° Euclidis phaenomena, cum expositione Maurolyci.

Colbertinus

1.° Autolyci liber de sphaera quae movetur, cum interpretatione et commentario Francisci Maurolyci. — 2.° Theodosii de habitationibus, de noctibus ac diebus libri duo, cum ejusdem Maurolyci interpretatione et notis. — 3.° Autolyci de vario ortu et occasu siderum non errantium libri duo : interprete Francisco Maurolyco.

Colbertinus

radices motuum, latera diametrorum, distantiae tabellae, cum regulis ad calculum pertinentibus et demonstrationibus : authore Francisco Maurolyco.

Colbertinus

Hieronymi Cardani, Mediolanensis Medici, commentariorum in Euclidis elementa libri novem.

Mazarinaeus

1.° Francisci Barocii, Patricii Veneti, lectiones in Procli commentarios in primum Euclidis elementorum librum : finis desideratur ; praemittuntur Christoph. Clavii, Fran. Barocii et aliorum epistolae nonnullae : italico idiomate. — 2.° Excerpta è sancto Augustino et Lud. Vive de Sibylla Erythrea.

D. Dufresne

[caractères grecs] seu transparentium libellus in tres partes divisus : authore Francisco Maurolyco.

Colbertinus