Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels.

Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.

Asdiwal. Revue genevoise d'anthropologie et d'histoire des religions

ASDIWAL. Revue genevoise d’anthropologie et d’histoire des religions, émanation de la Société genevoise d’histoire des religions, paraît chaque année depuis 2006. Son siège est établi à l’Université de Genève, Faculté des lettres, Unité d’histoire des religions. Héros de la mythologie tsimshian (Colombie-Britannique), Asdiwal est un personnage qui voyage, qui passe d’un monde à l’autre, sans jamais pouvoir dépasser ce qui fait de lui un Homme. Aujourd’hui, les cloisons qui séparent les différentes sciences humaines tendent elles aussi à s’effacer. Aussi, la revue ASDIWAL se donne-t-elle pour ambition, comme son héros éponyme, de faire voyager le lecteur d’un monde à l’autre. ASDIWAL revendique une approche anthropologique et historique du champ religieux, respectueuse des contextes culturels et sensible aux écarts comme aux ressemblances. Sans limite quant aux domaines abordés, la Revue genevoise d’anthropologie et d’histoire des religions plaide résolument pour une démarche comparatiste et un « regard éloigné », sans oublier un esprit de liberté et d'humour. Eclectique et ouverte, ASDIWAL donne la parole aussi bien à de jeunes chercheurs qu'à des spécialistes reconnus.

Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D

Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors form a transport machinery that localizes a remarkable diversity of mRNAs to specific cellular regions during oogenesis and embryogenesis. Bic-D family proteins also promote dynein-dependent transport of Golgi vesicles, lipid droplets, synaptic vesicles and nuclei. However, the transport of these different cargoes is still poorly understood. We searched for novel proteins that either mediate Bic-Ddependent transport processes or are transported by them. Clathrin heavy chain (Chc) co-immunopurifies with Bic-D in embryos and ovaries, and a fraction of Chc colocalizes with Bic-D. Both proteins control posterior patterning of the Drosophila oocyte and endocytosis. Although the role of Chc in endocytosis is well established, our results show that Bic-D is also needed for the elevated endocytic activity at the posterior of the oocyte. Apart fromaffecting endocytosis indirectly by its role in osk mRNA localization, Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex, pointing to an additional,more direct role of Bic-D in the endocytic pathway. Furthermore, similar to Bic-D, Chc also contributes to proper localization of osk mRNA and to oocyte growth. However, in contrast to other endocytic components and factors of the endocytic recycling pathway, such as Rabenosyn-5 (Rbsn-5) and Rab11, Chc is needed during early stages of oogenesis (from stage 6 onwards) to localize oskmRNA correctly.Moreover,we also uncovered a novel, presumably endocytosis-independent, role of Chc in the establishment of microtubule polarity in stage 6 oocytes.

Management of postpartum hemorrhage (PPH): algorithm of the interdisciplinary D-A-CH consensus group PPH (Germany – Austria – Switzerland)

Postpartum hemorrhage (PPH) is one of the main causes of maternal deaths even in industrialized countries. It represents an emergency situation which necessitates a rapid decision and in particular an exact diagnosis and root cause analysis in order to initiate the correct therapeutic measures in an interdisciplinary cooperation. In addition to established guidelines, the benefits of standardized therapy algorithms have been demonstrated. A therapy algorithm for the obstetric emergency of postpartum hemorrhage in the German language is not yet available. The establishment of an international (Germany, Austria and Switzerland D-A-CH) "treatment algorithm for postpartum hemorrhage" was an interdisciplinary project based on the guidelines of the corresponding specialist societies (anesthesia and intensive care medicine and obstetrics) in the three countries as well as comparable international algorithms for therapy of PPH.The obstetrics and anesthesiology personnel must possess sufficient expertise for emergency situations despite lower case numbers. The rarity of occurrence for individual patients and the life-threatening situation necessitate a structured approach according to predetermined treatment algorithms. This can then be carried out according to the established algorithm. Furthermore, this algorithm presents the opportunity to train for emergency situations in an interdisciplinary team.

Die Grundlegung jüdischer Lehre für Haus und Schule : zugl. als theoret. Begründung u. prakt. Einf. in d. Gebrauch d. vom Verf. hrsg. hebräischen Lehrbücher leson limmudim dargest.

von Daniel Fink

Beiträge zu einer Geschichte der Schulen und der Cultur unter den Juden : von d. Rückkehr aus d. babylonischen Exil bis zum Schlusse d. Talmuds

von Daniel Ehrmann

Aperçu général de la gestion de 1825 à 1838 : Rapport présenté par la commission administrative

Société d'encouragement au travail en faveur Israélites indigents du Bas-Rhin

Gedenkboek ter gelegenheid van het honderjarig bestaan van het Nederlandsch Israelietisch armbestuur te Amsterdam : 1825 - 1925

samengest. door S. I. Philips

Die Vertreibung der Juden aus der Bukowina 1774 - 1783

Aus: Jeschurun 15,1/2, 3/4

Lešōn limmūdīm

von Daniel Fink

Lešōn limmūdīm

von Daniel Fink

Maʿaśē Šôšān : ir libn laiṭ ṭuṭ lainn dś groś ḥiduš waś da iz gšehn ... ez iz oif loišn hakoideš gdrukṭ gwarn ...

Jaʿakov Brogr mip-Prag matik gwezn oif ṭaiṭš ...