Factors that affect non-adherence to first line antiretroviral medications among HIV infected children and adolescents in Botswana

The aims of the study were to determine the prevalence of and factors that affect non-adherence to first line antiretroviral (ARV) medications among HIV infected children and adolescents in Botswana. The study used secondary data from Botswana-Baylor Children's Clinical Center of Excellence for the period of June 2008 to February 10th, 2010. The study design was cross-sectional and case-comparison between non-adherent and adherent participants was used to examine the effects of socio-demographic and medication factors on non-adherence to ARV medications. A case was defined as non-adherent child with adherence level < 95% based on pill count and measurement of liquid formulations. The comparison group consisted of children with adherence levels ≥95%.^ A total of 842 participants met the eligibility criteria for determination of the prevalence of non-adherence and 338 participants (169 cases and 169 individuals) were used in the analysis to estimate the effects of factors on non-adherence. ^ Univariate and multivariable logistic regression were used to estimate the association between non-adherence (outcome) and socio-demographic and medication factors (exposures). The prevalence of non-adherence for participants on first line ARV medications was 20.0% (169/842).^ Increase in age (OR (95% CI): 1.10 (1.04–1.17) p = 0.001) was associated with nonadherence, while increase in number of caregivers (OR (95% CI): 0.72 (0.56–0.93) p = 0.01) and increase in number of monthly visits (OR (95% CI): 0.92 (0.86–0.99) p = 0.02), were associated with good adherence in both the unadjusted and the adjusted models. For the categorical variables, having more than two caregivers (OR (95% CI): 0.66 (0.28–0.84), p = 0.002) was associated with good adherence even in the adjusted model. ^ Conclusion. The prevalence of non-adherence to antiretroviral medicines among the study population was estimated to be 20.0%. In previous studies, adherence levels of ≥ 95% have been associated with better clinical outcomes and suppression of virus to prevent development of resistance. Older age, fewer numbers of caregivers and fewer monthly visits were associated with non-adherence. Strategies to improve and sustain adherence especially among older children are needed. The role of caregivers and social support should be investigated further.^

Social network size and perceived network sufficiency as predictors of perceived health status

This study focused on the relationship between social network size (number of friends and relatives), perceived sufficiency of the network and self-rated health utilizing data from the National Survey of Personal Health Practices and Consequences, 1979. For men neither perceived sufficiency nor number of relatives were associated with self-rated health status. The number of friends was positively associated with health status. For women perceived network sufficiency was positively and significantly related to health status, independent of network size. The number of friends and relatives was not associated with self-rated health status. The sociodemographic variables accounted for most of the explained variance in health status for both males and females. Social networks may hold different meanings for women and men, and may require qualitative as well as quantitative analysis. There may have been insufficient variance in the major variables to produce meaningful results. ^

El hermetismo del mito de Adonis en la literatura británica

Si bien el termino Adonai o su variante Adonis en la mitología Griega remiten tanto a la divinidad Bíblica como a la mitología antigua e inclusive a los tratados filosóficos de Aristóteles o Spinoza, es curioso que el concepto haya sido personificado y alegorizado con tanta frecuencia en la literatura Anglófona, inclusive en textos cuya interpretación tradicional ha sido de carácter secular. La forma fragmentada en la que la crítica ha entendido el concepto Adonai en obras clásicas de escritores como Shakespeare, Spenser, Milton, Blake, Coleridge, Shelley, Bulwer, Joyce, T. S. Eliot, entre otros se convierte en el desencadenante de debates no solo literarios sino también filosóficos y religiosos como por ejemplo los desatados por la aparición de El Código Da Vinci (en su formato de novela y de película), en el que el concepto Adonai es recreado desde una perspectiva esotérica que invita a reconsiderar la concepción del mismo en los clásicos escritos siglos antes. Si el contacto que tuvieron Shelley, Shakespeare, Milton, Spenser, Bulwer, Blake y Joyce con la doctrina hermética les proporcionó el sustento simbólico y el imaginario alquímico de sus obras, entonces se puede afirmar que sus obras pueden condensar de manera alegórica el conocimiento que ellos tenían de las ciencias ocultas. Si el mito de Adonis alegóricamente recrea, de acuerdo al hermetismo, la caída sexual de Adonis, y a través de él la caída de la humanidad, entonces las obras analizadas aludirían a la debilidad carnal del ser humano. Si se puede descubrir una esencia arquetípica de Adonis en las obras estudiadas y asimismo detectarse un paralelismo en las ideas planteadas por la película norteamericana The Da Vinci Code, entonces es posible identificar analogías y relaciones entre los intereses artísticos e ideológicos presentes en ambas culturas.

“Dishonourable disobedience” – Why refusal to treat in reproductive healthcare is not conscientious objection

In medicine, the vast majority of conscientious objection (CO) is exercised within the reproductive healthcare field – particularly for abortion and contraception. Current laws and practices in various countries around CO in reproductive healthcare show that it is unworkable and frequently abused, with harmful impacts on women's healthcare and rights. CO in medicine is supposedly analogous to CO in the military, but in fact the two have little in common. This paper argues that CO in reproductive health is not actually Conscientious Objection, but Dishonourable Disobedience (DD) to laws and ethical codes. Healthcare professionals who exercise CO are using their position of trust and authority to impose their personal beliefs on patients, who are completely dependent on them for essential healthcare. Health systems and institutions that prohibit staff from providing abortion or contraception services are being discriminatory by systematically denying healthcare services to a vulnerable population and disregarding conscience rights for abortion providers. CO in reproductive healthcare should be dealt with like any other failure to perform one's professional duty, through enforcement and disciplinary measures. Counteracting institutional CO may require governmental or even international intervention.

Spectral reflectance library of selected biotic and abiotic coral reef features in Glovers Reef, Belize

Underwater spectral reflectance was measured for selected biotic and abiotic coral reef features of Glovers Reef, Belize from March 6 - 10, 2005. Spectral reflectance's of 63 different benthic types were obtained in-situ. An Ocean Optics USB2000 spectrometer was deployed in an custom made underwater housing with a 0.5 m fiber-optic probe mounted next to an artificial light source. Spectral readings were collected with the probe (bear fibre) about 5 cm from the target to ensure that the target would fill the field of view of the fiber optic (FOV diameter ~4.4 cm), as well as to reduce the attenuating effect of the intermediate water (Roelfsema et al., 2006). Spectral readings included for one target included: 1 reading of the covered spectral fibre to correct for instrument noise, 1 reading of spectralon panel mounted on divers wrist to measure incident ambient light, and 8 readings of the target. Spectral reflectance was calculated for each target by first subtracting the instrument noise reading from each other reading. The corrected target readings were then divided by the corrected spectralon reading resulting in spectral reflectance of each target reading. An average target spectral reflectance was calculated by averaging the eight individual spectral reflectance's of the target. If an individual target spectral reflectance was visual considered an outlier, it was not included in the average spectral reflectance calculation. See Roelfsema at al. (2006) for additional info on the methodology of underwater spectra collection.

Cruces post estructuralistas entre la Geografía y la Literatura

¿Por qué no pensar en John Steimbeck para una relación entre la narrativa, la cuestión social, la marginalidad y la espacialidad, en un Joseph Conrad sobre el colonialismo o en el James Joyce de la vida cotidiana?. Estos temas se podrían explorar a través de la crítica tradicional, pero el giro posmoderno hizo revalorizar las relaciones entre la literatura y geografía. El geógrafo estadounidense Edward Soja, comenzando su análisis en El Aleph de Borges y especialmente en Henri Lefebvre fue pionero fundamentando su teoría del Tercer Espacio. El geógrafo británico Nigel Thrift elabora su teoría no representacional en su crítica a la racionalidad y nos alienta a cierto alejamiento de las representaciones espaciales, lineales y directas en la escritura y la lectura. Para finalizar también se indaga en los re posicionamientos de las teorías poscoloniales y su impacto en la literatura y se explicitan conclusiones provisorias

Cruces post estructuralistas entre la Geografía y la Literatura

¿Por qué no pensar en John Steimbeck para una relación entre la narrativa, la cuestión social, la marginalidad y la espacialidad, en un Joseph Conrad sobre el colonialismo o en el James Joyce de la vida cotidiana?. Estos temas se podrían explorar a través de la crítica tradicional, pero el giro posmoderno hizo revalorizar las relaciones entre la literatura y geografía. El geógrafo estadounidense Edward Soja, comenzando su análisis en El Aleph de Borges y especialmente en Henri Lefebvre fue pionero fundamentando su teoría del Tercer Espacio. El geógrafo británico Nigel Thrift elabora su teoría no representacional en su crítica a la racionalidad y nos alienta a cierto alejamiento de las representaciones espaciales, lineales y directas en la escritura y la lectura. Para finalizar también se indaga en los re posicionamientos de las teorías poscoloniales y su impacto en la literatura y se explicitan conclusiones provisorias

Cruces post estructuralistas entre la Geografía y la Literatura

¿Por qué no pensar en John Steimbeck para una relación entre la narrativa, la cuestión social, la marginalidad y la espacialidad, en un Joseph Conrad sobre el colonialismo o en el James Joyce de la vida cotidiana?. Estos temas se podrían explorar a través de la crítica tradicional, pero el giro posmoderno hizo revalorizar las relaciones entre la literatura y geografía. El geógrafo estadounidense Edward Soja, comenzando su análisis en El Aleph de Borges y especialmente en Henri Lefebvre fue pionero fundamentando su teoría del Tercer Espacio. El geógrafo británico Nigel Thrift elabora su teoría no representacional en su crítica a la racionalidad y nos alienta a cierto alejamiento de las representaciones espaciales, lineales y directas en la escritura y la lectura. Para finalizar también se indaga en los re posicionamientos de las teorías poscoloniales y su impacto en la literatura y se explicitan conclusiones provisorias

Biochar and compost effects on mobility of Cu and other soil parameters and plant growth

A pot experiment was conducted to determine the effects of three biochars and compost on plant growth and the immobilisation of Cu in a contaminated soil obtained from a former wood preservation site in the Gironde County Saint Médard d'Eyrans, France (N 44° 43.353, W 0° 30.938). To assess Cu mobility, amended soils were analysed using CaCl**2 leaching tests pre- and post-incubation, and post-growth. Amended and unamended soils were planted with sunflower, and the resulting plant material was assessed for yield (mass and height) and Cu concentration. All amendments significantly reduced leachable Cu compared to the unamended soil, however, the greatest reductions in leachable Cu were associated with the higher biochar application rate. The greatest improvements in plant yields were obtained with the higher application rate of biochar in combination with compost. pH, DOC, EH were measured in soils to help explain the leaching and plant growth trends. Soil pore water was collected during plant growth and analysed for metal concentration, pH and EH. Prior to treatment, background analyses were carried out on the soil and individual amendments (including PAH + metal concentrations measured by gas chromatography mass spectrometry and ICP-AES respectively).

Studentisches Medienprojekt zur Internationalen REKLIM Konferenz in Kooperation mit der DEKRA-Hochschule Berlin

Ein interdisziplinäres und interaktives Medienprojekt von und für junge Menschen zum Thema "Regionale Klimaänderungen". Der Klimawandel ist eines der wichtigsten Zukunftsthemen und Handlungsfelder unserer Zivilgesellschaft, mit weltweiter Relevanz und regionalen Auswirkungen. Die jungen Menschen heute sind diejenigen, die in Zukunft von den Folgen der Klimaveränderungen besonders stark betroffen sein werden. Sie sind aber auch gleichzeitig gefordert zu erkennen, dass wir andere Lebensstile finden und Vermeidungs- und Anpassungsstrategien jetzt auf den Weg bringen müssen, da diese Maßnahmen nur sehr langfristig wirken. Es liegt noch zu wenig im Erfahrungs- und Erlebenshorizont vieler junger Menschen, Maßnahmen zu Klimaschutz und -anpassung als wichtige Bausteine für die eigene Zukunft zu begreifen und aktiv als Thema anzunehmen. Daher bedarf es einer frühen und intensiven Auseinandersetzung mit dieser gesellschaftlichen Herausforderung als Teil der eigenen Lebenswirklichkeit. Zielgruppe des Medienprojektes war hier die heranwachsende Generation im Ausbildungsalter (16-30 Jahre). Die Helmholtz-Klimainitiative REKLIM (Regionale Klimaänderungen) und die DEKRA Hochschule Berlin haben sich 2013 gemeinsam auf den Weg gemacht, den Prozess der Auseinandersetzung und der Bewusstseinsbildung für die Bedeutung dieses Themas für junge Menschen in einem gemeinsamen interdisziplinären Projekt anzustoßen (www.reklim-medienprojekt.de). Gewählt für die Umsetzung dieses Projektes wurde die internationale REKLIM Konferenz "Our Climate - Our Future, Regional Perspectives on a global Challenge", die vom 6. - 9. Oktober 2014 in Berlin stattfand. Das ins Leben gerufene Medienprojekt zu dieser wissenschaftlichen Konferenz vereinte die Expertisen beider Projektpartner, um das Thema "Regionale Klimaänderungen" von jungen Menschen für junge Menschen zu adressieren und sie in ihrer eigenen Sprache und Mediennutzung zu erreichen. Insgesamt konnten mehr als 80 Studierende aus den Studiengängen Fernsehen und Film, Journalismus und Medienmanagement der DEKRA Hochschule Berlin in diesem einzigartigen Projekt in die Wissenschaftskonferenz eingebunden werden. Mit selbst konzipierten und produzierten Medienprodukten (u.a. einem Blog, mehreren Dokumentarfilmen, Viralen Videos sowie täglichen Berichterstattungen) für die Öffentlichkeit sollten die regionalen Aspekte des Klimawandels, die in der Helmholtz-Klimainitiative REKLIM wissenschaftlich erarbeitet werden, der Öffentlichkeit zugänglich gemacht werden. Den Studierenden kam dabei die wichtige Rolle zu, die wissenschaftlichen Inhalte in eine filmkünstlerische, journalistische und junge Sprache zu transformieren, mit unvoreingenommener Perspektive auf die Probleme zu schauen und die Wissenschaftlerinnen und Wissenschaftler dabei gleichsam mit einzubinden. So ist in dem Projekt ein wichtiger Dialog- und Lernprozess zwischen den verschiedenen Disziplinen entstanden. Darüber hinaus bot die Zusammenarbeit für die Wissenschaftlerinnen und Wissenschaftler des REKLIM-Verbunds und der beteiligten Zentren eine einmalige Chance, eine mediale Öffentlichkeit herzustellen, die es in dieser Form vermutlich für eine derartige Konferenz noch nicht gegeben hat. Für die Studierenden der DEKRA Hochschule bedeutete das Medienprojekt wichtige Erfahrungen in der projektbezogenen Arbeit mit einem externen Partner zu einem gesellschaftsrelevanten Thema zu sammeln. Das REKLIM-Medienprojekt verfolgt die Ziele: - in einem interdisziplinären und interaktiven Projekt junge Menschen zur Auseinandersetzung mit dem Klimawandel und zur Bewusstseinsbildung für die Bedeutung der regionalen Klimaänderungen anzuregen, - durch die von den Studierenden entwickelten Medienprodukte eine Verbindung zwischen den wissenschaftlichen Arbeiten und einer breiten Öffentlichkeit zu ermöglichen, - einen Dialogprozess zwischen Wissenschaftler/-innen und Studierenden zu initiieren, - wissenschaftliche Inhalte über künstlerische und mediale Transferprozesse anschaulich und ansprechend einer breiten Öffentlichkeit, insbesondere jungen Menschen, näherzubringen, um sie für das Thema Klimawandel und seine regionalen Auswirkungen zu sensibilisieren, - einen Dialog- und Lernprozess zwischen den verschiedenen Disziplinen anzuregen.

Literature review of elasmobranch bycatch and retention rate

To address growing concern over the effects of fisheries non-target catch on elasmobranchs worldwide, the accurate reporting of elasmobranch catch is essential. This requires data on a combination of measures, including reported landings, retained and discarded non-target catch, and post-discard survival. Identification of the factors influencing discard vs. retention is needed to improve catch estimates and to determine wasteful fishing practices. To do this we compared retention rates of elasmobranch non-target catch in a broad subset of fisheries throughout the world by taxon, fishing country, and gear. A regression tree and random forest analysis indicated that taxon was the most important determinant of retention in this dataset, but all three factors together explained 59% of the variance. Estimates of total elasmobranch removals were calculated by dividing the FAO global elasmobranch landings by average retention rates and suggest that total elasmobranch removals may exceed FAO reported landings by as much as 400%. This analysis is the first effort to directly characterize global drivers of discards for elasmobranch non-target catch. Our results highlight the importance of accurate quantification of retention and discard rates to improve assessments of the potential impacts of fisheries on these species.