Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate

Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In this study, we evaluated the Sb content of tissues from male rats 24 h and three weeks after a 21-day course of treatment with MA (300 mg SbV/kg body wt/d, subcutaneous). Sb concentrations in the blood and organs were determined by inductively coupled plasma-mass spectrometry. In rats, as with in humans, the Sb blood levels after MA dosing can be described by a two-compartment model with a fast (t1/2 = 0.6 h) and a slow (t1/2 >> 24 h) elimination phase. The spleen was the organ that accumulated the highest amount of Sb, while bone and thyroid ranked second in descending order of tissues according to Sb levels (spleen >> bone, thyroid, kidneys > liver, epididymis, lungs, adrenals > prostate > thymus, pancreas, heart, small intestines > skeletal muscle, testes, stomach > brain). The pathophysiological consequences of Sb accumulation in the thyroid and Sb speciation in the liver, thyroid, spleen and bone warrant further studies.

Negotiation Techniques in a Digital Library

The Andalusian eHealth Library (Biblioteca Virtual del Sistema Sanitario Público de Andalucía, BV-SSPA), created in June 2006 as a strategic action of the Andalusian Government with the aim of becoming the engine for the knowledge management of the health system in the region, has meant a radical change of mind in the way libraries can be managed: - As a regional library, it coordinates the 42 document library centers of the hospital network. - It is an organization in charge of its own budget and management. - It is the only intermediary for contracting health science resources. These factors have empowered the library in its dealings with other organizations such as stakeholders, suppliers, universities, etc. The centralization of the purchasing and the librarian network has made this library strong enough to deal with the economic recession and budgetary problems.

New challenges, new skills for a digital library

The Andalusian eHealth Library (BV-SSPA) was set up in 2006, but the region already had 42 librarians who worked at hospitals or other centers and were in charge of their libraries. The Digital library meant for all of them the availability of a greater amount of scientific resources and also the challenge of adapting to this new environment which brought new tasks and responsibilities to their daily work, and required the development of new skills. The time has arrived to analyze how they have implemented this change and how it has transformed their professional profile within the Andalusian Health System. Nowadays, the Andalusian eHealth Library establishes the librarian’s targets and their work is evaluated according to the fulfillment of these targets. This evaluation is carried out by the director of the BV-SSPA, taking into account the performance related to the general stated targets, as well as their level of commitment to the Digital Library through the performing of specific assigned tasks.

Modelling scenarios of diffusion and control of pandemic influenza, italy

En aquest article es resumeixen els resultats publicats en un informe de l' ISS (Istituto Superiore di Sanità) del desembre de 2006, sobre un model matemàtic desenvolupat per un grup de treball que inclou a investigadors de les Universitats de Trento, Pisa i Roma, i els Instituts Nacionals de Salut (Istituto Superiore di Sanità, ISS), per avaluar i mesurar l'impacte de la transmissió i el control de la pandèmia de grip

La storia del diritto privato e l’organizzazione giuridica nell’antica Persia

Il sottoscritto lavoro e ricerca è risultato di circa tre anni di ricerche presso l’Università autonoma di Barcellona ed altre università europee ed iraniane. Il tema della ricerca s’intitola “La storia del Diritto Privato e l’organizzazione giuridica nell’antica Persia” ed è stato realizzato con la gentile direzione della Professoressa Gete Alonso, cattedratica di Diritto Civile presso l’Università Autonoma di Barcellona. In questo lavoro si è parlato maggiormente di due dinastie principali dell’era antica persiana ovvero la dinastia degli achemenide ed i sassani , ovvero un periodo di tempo tra l’anno 550 a.c. ed il 651 d.c. in qui fu il culmine dell’evoluzione storica e giuridica iraniana nell’antica Persia che va a sostituirsi con l’attacco e l’invasione araba e l’inizio dell’era islamica. Questo studio ci offre una base adatta ad effettuare di un lato uno studio comparato tra un sistema giuridico mediorientale antico con altri sistemi giuridici vigenti al tempo nel mondo come l’antica Babilinia, Grecia e Roma e d'altronde creare una base per confrontare il diritto antico applicato in Persia con il diritto attuale applicato nella Repubblica Islamica dell’Iran e quindi proporre una base di studio comparato nel tempo e tra vari sistemi giuridici antichi. Spero tanto che questa ricerca possa essere utile agli studiosi interessati a conoscere vari sistemi giuridici per poi confrontarli con altri sistemi antichi ed oggigiorno vigenti in modo tale di poter migliorare giorno dopo giorno le idee giuridiche applicabili nei vari sistemi attuali.

Lactic acid bacteria from fresh fruit and vegetables as biocontrol agents of phytopathogenic bacteria and fungi

This study evaluated the efficacy of lactic acid bacteria (LAB) isolated from fresh fruits and vegetables as biocontrol agents against the phytopathogenic and spoilage bacteria and fungi, Xanthomonas campestris, Erwinia carotovora, Penicillium expansum, Monilinia laxa, and Botrytis cinerea. The antagonistic activity of 496 LAB strains was tested in vitro and all tested microorganisms except P. expansum were inhibited by at least one isolate. The 496 isolates were also analyzed for the inhibition of P. expansum infection in wounds of Golden Delicious apples. Four strains (TC97, AC318, TM319, and FF441) reduced the fungal rot diameter of the apples by 20%; only Weissella cibaria strain TM128 decreased infection levels by 50%. Cell-free supernatants of selected antagonistic bacteria were studied to determine the nature of the antimicrobial compounds produced. Organic acids were the preferred mediators of inhibition but hydrogen peroxide was also detected when strains BC48, TM128, PM141 and FF441 were tested against E. carotovora. While previous reports of antifungal activity by LAB are scarce, our results support the potential of LAB as biocontrol agents against postharvest rot. [Int Microbiol 2008; 11(4):231-236]

Extracción de contextos definitorios hacia la elaboración en corpus especializados: de una herramienta de ayuda terminográfica

Uno de los objetivos principales del trabajo terminográfico es la identificación de conocimientosobre los términos que aparecenen textos especializados. Para confeccionar diccionarios, glosarios u ontologías, los terminógrafos suelen buscar definiciones sobre los términos que pretenden definir. La búsqueda de definiciones se puede hacer apartir de corpus especializados, donde normalmente aparecen en contextos definitorios, es decir, en fragmentos de texto donde un autor explícitamente define el término en cuestión. Hoy en día hay un interés creciente por automatizar este proceso, basado enla búsqueda de patrones definitorios sobre corpus especializados anotados morfosintácticamente. En este artículo presentamos una investigación centrada en la extracción automática de contextos definitorios. Presentamos una metodología que incluye tres procesos automáticos diferentes: la extracción de ocurrencias de patrones definitorios, el filtradode contextos no relevantes, y la identificación de elementos constitutivos, es decir, términos, definiciones y patrones pragmáticos.

H. Itàlia, la gran mutació (Berlusconi)

Conté: Italia, en la gran mutación; Italia, ante el factor B; Italia: leyes a la medida; Andreotti, dos caras de Italia; Berlusconi, cogido en sus trampas; Italia, partida en dos; Italia, en el disparadero; Italia a la deriva; Roma, entre las varias Italias; Berlusconi: dos caras, a cual peor

Bases metolológicas para la traducción jurídica: traductología, derecho comparado y lexicografía bilingüe

El presente trabajo sistematiza y analiza las principales obras de referencia de tres ámbitos interdisciplinarios: la traducción jurídica, el derecho comparado y la lexicografía bilingüe con el fin de establecer una base metodológica para la producción de un futuro diccionario bilingüe rumano-español para la traducción. Observamos una falta de repertorios lexicográficos rumano-español en el marco jurídico. El análisis que presentamos se enfoca en el tratamiento de la equivalencia de las unidades léxicas relacionadas con el derecho de asilo en cuatro diccionarios bilingües de carácter general. El resultado más significativo de nuestra investigación es que estos diccionarios no reúnen técnicas de traducción jurídica y métodos de derecho comparado.

La Macedonia / descritta da Giacomo Cantelli da Vignola suddito, è Geografo del Serenis[si]mo Sig[no]r Duca di Modena ; Fran[cesc]us Donia Mess[anens]is sculp[si]t

Échelle(s) : [1:895 000 environ], Miglia Italiane 30 [= 6,1 cm]

Macedonia Epiro Livadia Albania e Ianna / divise nelle sue parti principali da Giacomo Cantelli da Vignola, su l'Esemplare delle Carte migliori, é sù le più recenti Relazioni, ... ; Fran[cesc]us Donia Messanensis sculp[si]t

Échelle(s) : [1:1 460 500 environ], Scala di Miglia Italiane 60 [= 7,6 cm]