Special investigation of the City of Defiance for the period March 12, 2013 through April 30, 2015

Special investigation of the City of Defiance for the period March 12, 2013 through April 30, 2015

CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.

In mammals, transcriptional autorepression by Period (PER) and Cryptochrome (CRY) protein complexes is essential for the generation of circadian rhythms. We have identified CAVIN-3 as a new, cytoplasmic PER2-interacting protein influencing circadian clock properties. Thus, CAVIN-3 loss- and gain-of-function shortened and lengthened, respectively, the circadian period in fibroblasts and affected PER:CRY protein abundance and interaction. While depletion of protein kinase Cδ (PKCδ), a known partner of CAVIN-3, had little effect on circadian gene expression, CAVIN-3 required the PKCδ-binding site to exert its effect on period length. This suggests the involvement of yet uncharacterized protein kinases. Finally, CAVIN-3 activity in circadian gene expression was independent of caveolae.

Report on a review of the Iowa Department of Administrative Services (DAS) for the period April 5, 2011 through February 7, 2014

Report on a review of the Iowa Department of Administrative Services (DAS) for the period April 5, 2011 through February 7, 2014

Agreed-upon procedures report on the City of Urbana, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Urbana, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Sidney, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Sidney, Iowa for the period July 1, 2014 through June 30, 2015

Report on a special investigation of the Nutrition Department of the Northeast Hamilton Community School District for the period August 1, 2013 through June 4, 2014

Report on a special investigation of the Nutrition Department of the Northeast Hamilton Community School District for the period August 1, 2013 through June 4, 2014

Agreed-upon procedures report on the City of Glidden, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Glidden, Iowa for the period July 1, 2014 through June 30, 2015

Density, climate and varying return points: an analysis of long-term population fluctuations in the threatened European tree frog.

Experimental research has identified many putative agents of amphibian decline, yet the population-level consequences of these agents remain unknown, owing to lack of information on compensatory density dependence in natural populations. Here, we investigate the relative importance of intrinsic (density-dependent) and extrinsic (climatic) factors impacting the dynamics of a tree frog (Hyla arborea) population over 22 years. A combination of log-linear density dependence and rainfall (with a 2-year time lag corresponding to development time) explain 75% of the variance in the rate of increase. Such fluctuations around a variable return point might be responsible for the seemingly erratic demography and disequilibrium dynamics of many amphibian populations.

Agreed-upon procedures report on the City of Fruitland, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Fruitland, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Walcott, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Walcott, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Pleasanton, Iowa for the period July 1, 2014 through June 30, 2015

Agreed-upon procedures report on the City of Pleasanton, Iowa for the period July 1, 2014 through June 30, 2015

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Iowa Collection and Reporting System (ICAR) for the period April 1, 2013 through April 24, 2013 and April 1, 2014 through April 29, 2014

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Iowa Collection and Reporting System (ICAR) for the period April 1, 2013 through April 24, 2013 and April 1, 2014 through April 29, 2014

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Targeted Case Management System (TCM) for the period March 31, 2014 through April 18, 2014

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Targeted Case Management System (TCM) for the period March 31, 2014 through April 18, 2014

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Kindertrack System for the period March 30, 2015 through April 17, 2015

Report on a review of selected general and application controls over the Iowa Department of Human Services’ Kindertrack System for the period March 30, 2015 through April 17, 2015