Triangular Objects and Systematic K-Theory

We investigate modules over “systematic” rings. Such rings are “almost graded” and have appeared under various names in the literature; they are special cases of the G-systems of Grzeszczuk. We analyse their K-theory in the presence of conditions on the support, and explain how this generalises and unifies calculations of graded and filtered K-theory scattered in the literature. Our treatment makes systematic use of the formalism of idempotent completion and a theory of triangular objects in additive categories, leading to elementary and transparent proofs throughout.

Handbook of Disabled Children's Childhoods: Building Understandings: Child, Youth, Family and Disability. Palgrave Macmillan:Disabled Children in Out-of-Home Care: Issues and Challenges for Practice Kelly, B., Sandra, D. & Winter, K. 2016

This chapter provides an overview of some of the key findings from a large mixed methods study regarding disabled children in care in Northern Ireland

Majorantes para a ordem de subgrafos induzidos k-regulares

Muitos dos problemas de otimização em grafos reduzem-se à determinação de um subconjunto de vértices de cardinalidade máxima que induza um subgrafo k-regular. Uma vez que a determinação da ordem de um subgrafo induzido k-regular de maior ordem é, em geral, um problema NP-difícil, são deduzidos novos majorantes, a determinar em tempo polinomial, que em muitos casos constituam boas aproximações das respetivas soluções ótimas. Introduzem-se majorantes espetrais usando uma abordagem baseada em técnicas de programação convexa e estabelecem-se condições necessárias e suficientes para que sejam atingidos. Adicionalmente, introduzem-se majorantes baseados no espetro das matrizes de adjacência, laplaciana e laplaciana sem sinal. É ainda apresentado um algoritmo não polinomial para a determinação de umsubconjunto de vértices de umgrafo que induz umsubgrafo k-regular de ordem máxima para uma classe particular de grafos. Finalmente, faz-se um estudo computacional comparativo com vários majorantes e apresentam-se algumas conclusões.

Effects of vitamin K deficiency and its mechanisms in vertebrate's early development: zebrafish as a model

Disertação de mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2015

Action for a cleaner tomorrow : K-1

Action for a cleaner tomorrow, a South Carolina environmental curriculum supplement has been developed to teach the children of South Carolina and, ultimately, their parents to think about their daily habits and to make environmentally responsible choices. This curriculum supplement tries to reflect the environmental issues facing the world today with a particular emphasis on South Carolina’s concerns and goals. This document deals with grades K-1.

Annual message of his excellency Robert K. Scott, Governor of South Carolina, to the General Assembly, at the regular session, commencing November 28, 1871

This speech was delivered to by the Governor to give the general assembly information of the condition of the state and give them recommendations to consider measures that the Governor deems necessary or expedient. He provides the information regarding the state debt, taxes, and bonded debt. He describes the financial agent of the state as well as the expenditures of the state government.

Message of Robert K. Scott, Governor of South Carolina to the General Assembly, November 24, 1869

This speech was addressed to the people of the Senate and House of Representatives. It was delivered to inform them of the progress over the past year made to place the finances of the state on a firm and healthy basis. He gives a report on all departments and projects funded by the government in the past year.

K'cidade : um modo de viver a intervenção comunitária

Relatório de estágio de mestrado, Ciências da Educação (Formação de Adultos), Universidade de Lisboa, Instituto de Educação, 2011

Cost-Effectiveness of Non-Vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation in Portugal

INTRODUCTION AND OBJECTIVES:Recently, three novel non-vitamin K antagonist oral anticoagulants received approval for reimbursement in Portugal for patients with non-valvular atrial fibrillation (AF). It is therefore important to evaluate the relative cost-effectiveness of these new oral anticoagulants in Portuguese AF patients. METHODS: A Markov model was used to analyze disease progression over a lifetime horizon. Relative efficacy data for stroke (ischemic and hemorrhagic), bleeding (intracranial, other major bleeding and clinically relevant non-major bleeding), myocardial infarction and treatment discontinuation were obtained by pairwise indirect comparisons between apixaban, dabigatran and rivaroxaban using warfarin as a common comparator. Data on resource use were obtained from the database of diagnosis-related groups and an expert panel. Model outputs included life years gained, quality-adjusted life years (QALYs), direct healthcare costs and incremental cost-effectiveness ratios (ICERs). RESULTS:Apixaban provided the most life years gained and QALYs. The ICERs of apixaban compared to warfarin and dabigatran were €5529/QALY and €9163/QALY, respectively. Apixaban was dominant over rivaroxaban (greater health gains and lower costs). The results were robust over a wide range of inputs in sensitivity analyses. Apixaban had a 70% probability of being cost-effective (at a threshold of €20 000/QALY) compared to all the other therapeutic options. CONCLUSIONS:Apixaban is a cost-effective alternative to warfarin and dabigatran and is dominant over rivaroxaban in AF patients from the perspective of the Portuguese national healthcare system. These conclusions are based on indirect comparisons, but despite this limitation, the information is useful for healthcare decision-makers.

Toyota RAV4 model year marketing plan for the U.K

NSBE - UNL

The fourth extracellular loop of the alpha subunit of Na,K-ATPase. Functional evidence for close proximity with the second extracellular loop.

Na,K-ATPase is the main active transport system that maintains the large gradients of Na(+) and K(+) across the plasma membrane of animal cells. The crystal structure of a K(+)-occluding conformation of this protein has been recently published, but the movements of its different domains allowing for the cation pumping mechanism are not yet known. The structure of many more conformations is known for the related calcium ATPase SERCA, but the reliability of homology modeling is poor for several domains with low sequence identity, in particular the extracellular loops. To better define the structure of the large fourth extracellular loop between the seventh and eighth transmembrane segments of the alpha subunit, we have studied the formation of a disulfide bond between pairs of cysteine residues introduced by site-directed mutagenesis in the second and the fourth extracellular loop. We found a specific pair of cysteine positions (Y308C and D884C) for which extracellular treatment with an oxidizing agent inhibited the Na,K pump function, which could be rapidly restored by a reducing agent. The formation of the disulfide bond occurred preferentially under the E2-P conformation of Na,K-ATPase, in the absence of extracellular cations. Using recently published crystal structure and a distance constraint reproducing the existence of disulfide bond, we performed an extensive conformational space search using simulated annealing and showed that the Tyr(308) and Asp(884) residues can be in close proximity, and simultaneously, the SYGQ motif of the fourth extracellular loop, known to interact with the extracellular domain of the beta subunit, can be exposed to the exterior of the protein and can easily interact with the beta subunit.