A mi patria [Manuscrito]: elegía sinfónica

Dedicatoria : "Si de mi amada patria sin ventura / En trists notas la desdicha hoy canto, / Si anubla mi pupila raudo llanto / Y mi alma de español prueba amargura, / Un dulce lenitivo a mi tortura / Prestar puede la Fe: arcano santo / que trae a mi alma misterioso encanto / y un provenir de glorias aun le augura; / Mas, si ambición, con dolo vil y artero, / Destierra de mi patria la fortuna, / Sobre el frio mármol, con buril de acero, / (Por la que fué de tantos héroes cuna,) / Escriba este epitafio el orbe entero.../Fué noble, altiva y grande, cual ninguna!"

Coloqui nou del tio Vueltes [Texto impreso] : ahon referix el chasco que pasá en la festa de Burriana

Al fin : Es propietat del seu autor. Se venen en el Mercat, pará de romansos

Coloqui del chasco de Marsela [Texto impreso]

Hay un ejemplar encuadernado con: Poesías colocadas en el pórtico del Convento de San Francisco de Valencia (NP849.91/3086).

Arquitectura judicial en Aragón en la última centuria

La arquitectura judicial puede considerarse como la manifestación construida de uno de los aspectos fundamentales que definen una cultura, periodo histórico, o ámbito geográfico, que es la administración de justicia en cada sociedad. La Ley y el Derecho requieren unos ámbitos espaciales singulares en los que desarrollar los procesos que culminan con el acto judicial, el contraste de versiones e investigaciones que tienen como objetivo la búsqueda de la verdad por encima de todo. La arquitectura se configura como el escenario en el que tiene lugar el juicio, y ha de contribuir en este noble cometido. El conocimiento de la arquitectura judicial requiere -en primera instancia- un análisis arquitectónico, pero además esta visión se puede y se tiene que enriquecer con los enfoques que la propia práctica jurídica ha de aportar, y que en gran medida condicionan su creación y proyecto, en todo lo relativo a funcionalidad y simbología. Sin olvidar que nuestra formación es fundamentalmente arquitectónica, cabe plantear que el área de conocimiento a la que va dirigida esta investigación también se abre en diversas vías, que parten de la confluencia de aspectos legales, arquitectónicos, urbanos, y simbológicos. Además, todos estos aspectos son planteados en relación con las particularidades de una región concreta, Aragón, donde la ley ha tenido sus propias manifestaciones y códigos, donde la arquitectura y la ciudad se han contextualizado en un lugar concreto, y donde la simbología ha tenido su manera particular de transmitirse. Respecto a los objetivos que esta tesis plantea, podemos plantear en un primer estadio el análisis del carácter de la arquitectura judicial, como concepto y expresión amplia que manifiesta la función del edificio y su traducción en una simbología propia, y que queda vinculado, por lo tanto, a la funcionalidad de los procedimientos que en él tienen lugar y a la solemnidad alegórica de la Justicia. Para llevar a cabo este estudio se pretende establecer una metodología de estudio propia, que surge de considerar como valores formativos del tipo de arquitectura judicial a la tríada de valores urbanos, funcionales, y simbólicos. En primer lugar se evaluará la repercusión urbana de la arquitectura judicial, conforme a su consideración de equipamiento publico representativo de una sociedad. Se analizará, por lo tanto, si se dan posiciones urbanas concretas o arbitrarias, y si éstas se pueden tratar como una constante histórica. En segundo lugar, la especificidad y delicadeza de los usos que alberga llevan consigo planteamientos funcionales absolutamente complejos y específicos. Se considera que merece la pena analizarlos para evaluar si son propios de este tipo de arquitectura, así como su posible origen e implicación en la construcción del espacio judicial. En tercer lugar, se analizarán los edificios judiciales desde su consideración de soporte de una gran cantidad de materializaciones de simbológicas, no sólo desde un punto de vista iconográfico, sino además vinculadas a los procesos y ordenamientos judiciales, que se traducen en la construcción de espacios con una fuerte carga simbólica y escenográfica. En un segundo estadio se analiza la validez de la aplicación de dichos valores en el estudio de una serie de casos concretos de la arquitectura judicial en el territorio de Aragón en el siglo XX. Se buscará con ello la posibilidad de establecer variantes geográficas y temporales al tipo propias de esta comunidad, con unas particularidades forales que pueden dar lugar a ellas, así como posibles líneas evolutivas, o por el contrario, la imposibilidad de establecer pautas y relaciones a partir del análisis de los casos concretos y su valoración global. ABSTRACT Judicial architecture can be seen as the built manifestation of one of the key aspects that define a culture, a historical period, or a geographic scope, which is the administration of justice in every society. Law requires specific spaces to develop its own proceedings, that culminate with the judicial act. It is the contrast of versions and investigations that have an objective, the search for the truth. Architecture is configured as the stage in which the trial takes place, and has to contribute to this noble task. The knowledge of the judicial architecture requires -in the first instance - an architectural analysis, but in addition this vision can be enriched by some questions from the legal practice. They determine project decissions, specially functional and symbologycal aspects. Our main visión of the theme is architectural, but this research is also opened in many ways, that com from the confluence of legal, architectural, urban, and simbologic aspects In addition, all these questios are considered in relation to the peculiarities of a specific region, Aragon, where the law has its own manifestations and codes, where the architecture and the city have been contextualized in a particular way, and where the symbology has its particular way to be transmitted. About the objectives that this thesis purposes, we can suggest in a first stage the analysis of the character of the judicial architecture, as a concept that expresses the function of a building, and its translation into a particular symbology, allegorical to the solemnity of the Justice. To carry out the investigation proccess is neccesary to define a new methodology. It comes form considering the formative values of the judicial architecture, developed on the triad of urban, functional, and symbolic, values. Firstly, we analyse the urban aspects of judicial architecture, according to its consideration as a main public equipment of a society. Therefore we can search for specific or arbitrary urban locations of the courts, and if they can be considered as historic constants. Secondly, we analyse the specificity an complexity of the judicial uses, their possible origin, and involvement in the construction of judicial space. Thirdly, we analyse the court as scenographic stage, that support lots of symbolic elements and aspects linked to legal system. The second stage applies the values methodology on judicial architecture in Aragon in the twentieth century, with the possibility of establishing geographical and temporal variants os the court type in this community, or on the contrary, the inability to establish patterns and relationships from the analysis of specific cases and their overall rating.

Bando

Hay un ejemplar encuadernado con: La Real Compañia formada por S.M. para llevar a efecto el canal de navegación y riego del reyno de Murcia, las... experiencias de que informa D. Domingo Aguirre... le han confirmado en los abusos y fraudes que hacen muchos... (XVIII/4279).

Amadis de Gaula. Francés

Graesse, t. 1, p. 94: los libreros Rigaud, Robinot y Varennes encargaron esta continuación (libros XXII, XXIII y XXIV) que no ha existido nunca en español

O PAPEL DA COMUNICAÇÃO FACE A FACE NAS ORGANIZAÇÕES NO CONTEXTO DA SOCIEDADE MIDIATIZADA

Este estudo trata da comunicação face a face nas organizações sob diferentes abordagens teóricas. Considera a perspectiva da simultaneidade dos meios, já que as empresas utilizam diversos canais para dialogar com seus públicos de interesse. Leva em conta o fenômeno da midiatização, que reestrutura o modo como as pessoas se relacionam na sociedade contemporânea. O objetivo geral da pesquisa é sistematizar papeis potencialmente exercidos pela interação face a face e conhecer algumas circunstâncias que envolvem sua prática nas organizações. Por se tratar de uma tese teórica, a pesquisa bibliográfica se apresenta como um dos principais procedimentos metodológicos; análises de casos empíricos e um estudo de caso desenvolvido na Embrapa Pantanal constituem situações ilustrativas. Conclui-se que a comunicação face a face nas empresas ocorre de forma simultânea e combinada a outros canais de comunicação, porém, ela proporciona resultados práticos e filosóficos ainda pouco explorados. É rara a utilização estratégica de contatos presenciais como mecanismo para estabelecer relacionamentos, conhecer as reações alheias e ajustar a comunicação, aliar o discurso corporativo às práticas empresariais e avaliar o contexto onde se desenvolvem as interações, o que pode ser decisivo para a comunicação organizacional.

Resolving taxonomic uncertainty in vulnerable elasmobranchs : are the Madeira skate (Raja maderensis) and the thornback ray (Raja clavata) distinct species?

We are grateful to all those who helped with sample collection. This includes the MEDITS survey programme (IEO Mallorca) for Mediterranean samples. Portugal mainland samples were collected under the EU Data Collection Framework (DCF, PNAB). Azores specimens from the Department of Oceanography and Fisheries (DOP) of the University of the Azores (UAc) were collected under the project DEMERSAIS “Monitorização das espécies demersais dos Açores” financed by the Azorean government, and the project DEECON “Unravelling population connectivity for sustainable fisheries in the Deep Sea” project approved by the European Science Foundation (ESF) under the EUROCORES programme (proposal No 06-EuroDEEP-FP-008 & SFRH-EuroDEEP/0002/2007). This study was funded by the UK Natural Environment Research Council (NERC) Oceans 2025 Strategic Research Programme Theme 6 (Science for Sustainable Marine Resources). REB was supported by the Fisheries Society of the British Isles (FSBI), BSP was funded by the Fundação para a Ciência e a Tecnologia, SFRH/BPD/72351/2010 and JL was supported by The Alasdair Downes Marine Conservation Fund.

(Re)discovering the Gaulcross Hoard

Acknowledgements We would like to thank Charles and Helen Gray for permitting access to the land and for support in the excavation of the hoard. Thanks also to Bruce Mann and the Aberdeenshire Council Archaeology Service for advice and supporting the radiocarbon dating. Fraser Hunter and Tanja Romankiewicz assisted during a very cold excavation. Fraser and Alice Blackwell kindly read and commented on drafts of this paper. The fieldwork was funded through a donation to the University of Aberdeen’s Development Trust and undertaken as part of the Northern Picts project, in association with the Tarbat Discovery Centre.

Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro

As part of our attempts at understanding fundamental principles that underlie the generation of nondividing terminally differentiated progeny from dividing precursor cells, we have developed approaches to a quantitative analysis of proliferation and differentiation of oligodendrocyte type 2 astrocyte (O-2A) progenitor cells at the clonal level. Owing to extensive previous studies of clonal differentiation in this lineage, O-2A progenitor cells represent an excellent system for such an analysis. Previous studies have resulted in two competing hypotheses; one of them suggests that progenitor cell differentiation is symmetric, the other hypothesis introduces an asymmetric process of differentiation. We propose a general model that incorporates both such extreme hypotheses as special cases. Our analysis of experimental data has shown, however, that neither of these extreme cases completely explains the observed kinetics of O-2A progenitor cell proliferation and oligodendrocyte generation in vitro. Instead, our results indicate that O-2A progenitor cells become competent for differentiation after they complete a certain number of critical mitotic cycles that represent a period of symmetric development. This number varies from clone to clone and may be thought of as a random variable; its probability distribution was estimated from experimental data. Those O-2A cells that have undergone the critical divisions then may differentiate into an oligodendrocyte in each of the subsequent mitotic cycles with a certain probability, thereby exhibiting the asymmetric type of differentiation.

Inhibition of interferon γ induced interleukin 12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor

Inflammation is associated with production of cytokines and chemokines that recruit and activate inflammatory cells. Interleukin (IL) 12 produced by macrophages in response to various stimuli is a potent inducer of interferon (IFN) γ production. IFN-γ, in turn, markedly enhances IL-12 production. Although the immune response is typically self-limiting, the mechanisms involved are unclear. We demonstrate that IFN-γ inhibits production of chemokines (macrophage inflammatory proteins MIP-1α and MIP-1β). Furthermore, pre-exposure to tumor necrosis factor (TNF) inhibited IFN-γ priming for production of high levels of IL-12 by macrophages in vitro. Inhibition of IL-12 by TNF can be mediated by both IL-10-dependent and IL-10-independent mechanisms. To determine whether TNF inhibition of IFN-γ-induced IL-12 production contributed to the resolution of an inflammatory response in vivo, the response of TNF+/+ and TNF−/− mice injected with Corynebacterium parvum were compared. TNF−/− mice developed a delayed, but vigorous, inflammatory response leading to death, whereas TNF+/+ mice exhibited a prompt response that resolved. Serum IL-12 levels were elevated 3-fold in C. parvum-treated TNF−/− mice compared with TNF+/+ mice. Treatment with a neutralizing anti-IL-12 antibody led to resolution of the response to C. parvum in TNF−/− mice. We conclude that the role of TNF in limiting the extent and duration of inflammatory responses in vivo involves its capacity to regulate macrophage IL-12 production. IFN-γ inhibition of chemokine production and inhibition of IFN-γ-induced IL-12 production by TNF provide potential mechanisms by which these cytokines can exert anti-inflammatory/repair function(s).

Knowledge-based analysis of microarray gene expression data by using support vector machines

We introduce a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments. The method is based on the theory of support vector machines (SVMs). SVMs are considered a supervised computer learning method because they exploit prior knowledge of gene function to identify unknown genes of similar function from expression data. SVMs avoid several problems associated with unsupervised clustering methods, such as hierarchical clustering and self-organizing maps. SVMs have many mathematical features that make them attractive for gene expression analysis, including their flexibility in choosing a similarity function, sparseness of solution when dealing with large data sets, the ability to handle large feature spaces, and the ability to identify outliers. We test several SVMs that use different similarity metrics, as well as some other supervised learning methods, and find that the SVMs best identify sets of genes with a common function using expression data. Finally, we use SVMs to predict functional roles for uncharacterized yeast ORFs based on their expression data.

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

We have discovered that intracellular redox state appears to be a necessary and sufficient modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-type-2 astrocyte progenitor cells. The intracellular redox state of freshly isolated progenitors allows prospective isolation of cells with different self-renewal characteristics. Redox state is itself modulated by cell-extrinsic signaling molecules that alter the balance between self-renewal and differentiation: growth factors that promote self-renewal cause progenitors to become more reduced, while signaling molecules that promote differentiation cause progenitors to become more oxidized. Moreover, pharmacological antagonists of the redox effects of these cell-extrinsic signaling molecules antagonize their effects on self-renewal and differentiation, indicating that cell-extrinsic signaling molecules that modulate this balance converge on redox modulation as a critical component of their effector mechanism.