Positive selection drives population differentiation in the skeletal genes in modern humans

During the course of evolution, the human skeletal system has evolved rapidly leading to an incredible array of phenotypic diversity, including variations in height and bone mineral density. However, the genetic basis of this phenotypic diversity and the relatively rapid tempo of evolution have remained largely undocumented. Here, we discover that skeletal genes exhibit a significantly greater level of population differentiation among humans compared with other genes in the genome. The pattern is exceptionally evident at amino acid-altering sites within these genes. Divergence is greater between Africans and both Europeans and East Asians. In contrast, relatively weak differentiation is observed between Europeans and East Asians. SNPs with higher levels of differentiation have correspondingly higher derived allele frequencies in Europeans and East Asians. Thus, it appears that positive selection has operated on skeletal genes in the non-African populations and this may have been initiated with the human colonization of Eurasia. In conclusion, we provide genetic evidence supporting the rapid evolution of the human skeletal system and the associated diversity of phenotypes.

The role of adaptive thermal comfort in the prediction of the thermal performance of a modern mixed-mode office building in the UK under climate change

Climate change is becoming a serious issue for the construction industry, since the time scales at which climate change takes place can be expected to show a true impact on the thermal performance of buildings and HVAC systems. In predicting this future building performance by means of building simulation, the underlying assumptions regarding thermal comfort conditions and the related heating, ventilating and air conditioning (HVAC) control set points become important. This article studies the thermal performance of a reference office building with mixedmode ventilation in the UK, using static and adaptive thermal approaches, for a series of time horizons (2020, 2050 and 2080). Results demonstrate the importance of the implementation of adaptive thermal comfort models, and underpin the case for its use in climate change impact studies. Adaptive thermal comfort can also be used by building designers to make buildings more resilient towards change. © 2010 International Building Performance Simulation Association (IBPSA).

Size distribution of heavy mineral grains in some modern Nile Delta coastal sands, Egypt

This study includes determination and discussion of the texture and heavy mineral compositions of some modem Nile Delta coastal sands (river, coastal dune, beach-face, and nearshore marine) in order to delineate the process and factors that regulate the size distribution of heavy mineral grains comprising these coastal sands. Textural analysis of unseparated bulk samples indicate that the examined four types of sands differ in their mean grain sizes and degree of sorting. However, analysis of size distribution curves of 10 heavy mineral species or group of species in the four environments having the same general shape and nearly similar in that general order of arrangement. However, these curves vary both in median sizes and sorting. The size distribution of a heavy mineral in the Nile Delta coastal sands appear to depend on: (1) range of grain size fractions in each sample, (2) relative availability of heavy mineral in each size grade of the sample, (3) specific gravity of minerals comprising these sands, and (4) some other unknown factor or factors. Results of size measurement of heavy minerals indicated that increasing specific gravity is accompanied by increasing fineness of the heavy minerals. This study may be useful in search for marine placers and understanding the processes of grain-sorting on the sea beaches.

Cambodia: towards a modern commons

The Community Fisheries organizations in Cambodia possess the basic framework and principles to be considered good examples of a created ‘modern commons’....

Experimental study into the flow physics of three-dimensional shock control bumps

This paper describes a fundamental experimental study of the flow structure around a single three-dimensional (3D) transonic shock control bump (SCB) mounted on a flat surface in a wind tunnel. Tests have been carried out with a Mach 1.3 normal shock wave located at a number of streamwise positions relative to the SCB. Details of the flow have been studied using the experimental techniques of schlieren photography, surface oil flow visualization, pressure sensitive paint, and laser Doppler anemometry. The results of the work build on the findings of previous researchers and shed new light on the flow physics of 3D SCBs. It is found that spanwise pressure gradients across the SCB ramp and the shape of the SCB sides affect the magnitude and uniformity of flow turning generated by the bump, which can impact on the spanwise propagation of the quasi-two-dimensional (2D) shock structure produced by a 3DSCB. At the bump crest, vortices can form if the pressure on the crest is significantly lower than at either side of the bump. The trajectories of these vortices, which are relatively weak, are strongly influenced by any spanwise pressure gradients across the bump tail. Asignificant difference between 2D and 3D SCBs highlighted by the study is the impact of spanwise pressure gradients on 3D SCB performance. The magnitude of these spanwise pressure gradients is determined largely by SCB geometry and shock position. Copyright © 2011 by the American Institute of Aeronautics and Astronautics, Inc.

Fluid Dynamics in Physics, Engineering and Environmental Applications

The book contains invited lectures and selected contributions presented at the Enzo Levi and XVII Annual Meeting of the Fluid Dynamic Division of the Mexican Physical Society in 2011.

FPGA, physics-based modeling of IGBT and pin diode for hardware co-simulation of complex power electronic converters and systems

This paper presents the steps and the challenges for implementing analytical, physics-based models for the insulated gate bipolar transistor (IGBT) and the PIN diode in hardware and more specifically in field programmable gate arrays (FPGAs). The models can be utilised in hardware co-simulation of complex power electronic converters and entire power systems in order to reduce the simulation time without compromising the accuracy of results. Such a co-simulation allows reliable prediction of the system's performance as well as accurate investigation of the power devices' behaviour during operation. Ultimately, this will allow application-specific optimisation of the devices' structure, circuit topologies as well as enhancement of the control and/or protection schemes.

Flow physics of a normal-hole bled supersonic turbulent boundary layer

An experimental study on normal hole bleed in a supersonic turbulent boundary layer has been conducted. A combination of LDV, Schlieren imagery and oil flow visualization were used to provide a better understanding of the three-dimensional flow field surrounding a supersonic bleed array. Experiments were performed at Mach numbers of 1.8 and 2.5, while previously published results at Mach numbers of 1.3 and 1.5 were also incorporated. The bleed system was capable of removing up to approximately 10% of the incoming boundary layer through a tunnel-spanning array of discrete holes with diameters the same order of magnitude of boundary layer displacement thickness. Inspection of boundary layer profiles downstream of the bleed region indicates that vorticity generated by the discrete holes can have a substantial influence on changes to the boundary layer shape factor and skin friction coefficient, through modification of the lower 20% of the boundary layer. This vorticity was visualized through oil-flow visualization, and LDV measurements, showing the development of two vortices off each bleed hole, and corresponding upwash and downwash regions with far-reaching three dimensional effects. © 2013 by J. M. Oorebeek and H. Babinsky.