Inteligência obtida pela aplicação de data mining em base de teses francesas sobre o Brasil

O assunto Brasil foi analisado na base de teses francesas DocThèses, compreendendo os anos de 1969 a 1999. Utilizou-se a técnica de Data Mining como ferramenta para obter inteligência e conhecimento. O software utilizado para a limpeza da base DocThèses foi o Infotrans, e, para a preparação dos dados, empregou-se o Dataview. Os resultados da análise foram ilustrados com a aplicação dos pressupostos da Lei de Zipf, classificando-se as informações em trivial, interessante e ruído, conforme a distribuição de freqüência. Conclui-se que a técnica do Data Mining associada a softwares especialistas é uma poderosa aliada no emprego de inteligência no processo decisório em todos os níveis, inclusive o nível macro, pois oferece subsídios para a consolidação, investimento e desenvolvimento de ações e políticas.

Indicadores bibliométricos da produção científica brasileira: uma análise a partir da base Pascal

As atividades de produção de indicadores quantitativos em ciência, tecnologia e inovação vêm se fortalecendo no país na última década, com o reconhecimento da necessidade, por parte dos governos federal e estaduais e da comunidade científica nacional, de dispor de instrumentos para definição de diretrizes, alocação de investimentos e recursos, formulação de programas e avaliação de atividades relacionadas ao desenvolvimento científico e tecnológico no país. Este trabalho insere-se dentro deste contexto, ao apresentar e analisar os indicadores bibliométricos da produção científica e tecnológica de pesquisadores brasileiros ao longo dos anos 90, computados a partir de uma base bibliográfica internacional e multidisciplinar a Pascal francesa. A análise dos indicadores aqui apresentados mostra que o aumento da produção científica brasileira foi expressivo nos últimos 20 anos, assim como sua internacionalização. Ampliou-se a parceria de pesquisadores brasileiros com de outros países, nos EUA, Europa e também na América do Sul. Embora ainda fortemente concentrada em São Paulo e Rio de Janeiro, a participação da produção científica de pesquisadores de outros estados tem crescido significativamente, especialmente de Minas Gerais.

Combined use of the GGSFT data base and on Board Marine Collected Data to Model the Moho Beneath the Powell Basin, Antarctica

The Powell Basin is a small oceanic basin located at the NE end of the Antarctic Peninsula developed during the Early Miocene and mostly surrounded by the continental crusts of the South Orkney Microcontinent, South Scotia Ridge and Antarctic Peninsula margins. Gravity data from the SCAN 97 cruise obtained with the R/V Hespérides and data from the Global Gravity Grid and Sea Floor Topography (GGSFT) database (Sandwell and Smith, 1997) are used to determine the 3D geometry of the crustal-mantle interface (CMI) by numerical inversion methods. Water layer contribution and sedimentary effects were eliminated from the Free Air anomaly to obtain the total anomaly. Sedimentary effects were obtained from the analysis of existing and new SCAN 97 multichannel seismic profiles (MCS). The regional anomaly was obtained after spectral and filtering processes. The smooth 3D geometry of the crustal mantle interface obtained after inversion of the regional anomaly shows an increase in the thickness of the crust towards the continental margins and a NW-SE oriented axis of symmetry coinciding with the position of an older oceanic spreading axis. This interface shows a moderate uplift towards the western part and depicts two main uplifts to the northern and eastern sectors.

Hégémonie du modèle de l'autisme: carrefour epistémologique entre médecine, familles et politique [Hegemonic model of autism: epistemological crossroads between medicine, family and politics].

The aim of this article is to make a contribution to the regional reflection with regard to autism spectrum disorders (ASDs) at a key moment in which the authorities are requested by the users, professionals in the fields of health, pedagogy and education to put forward a structured answer to a multitude of expressed needs. The question for the creation of a competence pole of an academic tertiary level is posed in order to advise in the best possible way the families who do not know how to orient themselves in the maze and contradictions of the proposed solutions and to help the professionals who are submerged by an ever increasing demand of services exceeding the means of the existing institutions and who cannot justify their choices among the various existing theoretical and scientific models.

Gériatrie aiguë: un modèle d'unité intégree de soins aux seniors [How to prevent functional decline: an acute care unit model for the elderly].

Hospitalization in older patients is frequently associated with functional decline. Hospital factors and inadapted process of care are factors leading to this decline. Acute care units specifically developed for older patients can prevent functional decline. These units usually include a comprehensive geriatric evaluation, an interdisciplinary meeting, protocols for the treatment of geriatric syndromes and specific teaching for the care team. Globally, patients' cares are organized to preserve and improve functional performances. This article presents a pilot unit inspired by this model.

Gestão do conhecimento científico: proposta de um modelo conceitual com base em processos de comunicação científica

A gestão do conhecimento tem se desenvolvido no ambiente das organizações empresariais e tem suas pesquisas e aplicações voltadas para a perspectiva do conhecimento organizacional. No entanto, existem outros contextos nos quais a gestão do conhecimento pode ser estudada, como, por exemplo, o contexto acadêmico, voltado para a perspectiva do conhecimento científico. Independentemente do contexto em que se inserem, os processos de comunicação constituem uma questão fundamental a ser levada em consideração em estudos sobre gestão do conhecimento. Esta pesquisa se propôs a investigar a relação, em nível conceitual, entre a gestão do conhecimento e os processos de comunicação científica, tendo em vista as peculiaridades do contexto e do conhecimento científico. Mais especificamente, referiu-se a uma proposta teórica de construção de um modelo conceitual de gestão do conhecimento científico no contexto acadêmico, tendo por base os processos de comunicação científica.

Base de dados de informações jornalísticas sobre a Amazônia: ciência, tecnologia e meio ambiente - BDIJAm: em busca da qualidade

Apresenta a avaliação da qualidade da Base de Dados de Informações Jornalísticas sobre a Amazônia: Ciência, Tecnologia e Meio Ambiente - BDIJAm. O estudo integra o Projeto Temáticas Amazônicas: Dossiês Comentados e Qualidade da Informação sobre Ciência, Tecnologia e Meio Ambiente, do Museu Paraense Emílio Goeldi. Foram aplicados questionários aos usuários para identificação dos pontos positivos e possíveis lacunas do serviço. Como principais resultados foram apontadas a relevância dos temas da Base e a necessidade de se desenvolver ações que visem aperfeiçoar a estrutura de recuperação da informação. Conclui que toda base de dados deve ser continuamente aperfeiçoada e os usuários consideram a BDIJam um instrumento de suma importância para a sociedade como recurso de preservação da memória social da Amazônia.

Efetividade do processo de comunicação com base na abordagem do comportamento informacional: o caso de um organismo internacional da área da saúde pública sediado no Brasil

Aborda-se a efetividade do processo de comunicação organizacional do qual fazem parte o sítio web da Unidade Técnica de Sistemas e Serviços de Saúde da Organização Pan-Americana da Saúde (HSD/OPAS). A abordagem adotada fundamenta-se nos padrões de comportamento informacional de usuários do sítio da HSD/OPAS como insumo para o seu delineamento, a partir da noção de sistemas de informação apoiados em tecnologia. Utiliza-se a Metodologia de Sistemas Flexíveis (MSF), de Peter Checkland, com enfoque sistêmico e fenomenológico na identificação de ações que podem agilizar o processo de comunicação estudado, levando em conta os padrões de comportamento informacional de seus atores. Conclui-se que a efetividade do processo de comunicação entre gestores do setor de saúde pública e o sítio web da OPAS pode resultar da inserção dos padrões de comportamento informacional de gestores como subsídio ao delineamento do sistema de informação disponível no sítio web da HSD.

A new method to estimate the infilling of alluvial sediment of glacial valleys using a sloping local base level

A new method is used to estimate the volumes of sediments of glacial valleys. This method is based on the concept of sloping local base level and requires only a digital terrain model and the limits of the alluvial valleys as input data. The bedrock surface of the glacial valley is estimated by a progressive excavation of the digital elevation model (DEM) of the filled valley area. This is performed using an iterative routine that replaces the altitude of a point of the DEM by the mean value of its neighbors minus a fixed value. The result is a curved surface, quadratic in 2D. The bedrock surface of the Rhone Valley in Switzerland was estimated by this method using the free digital terrain model Shuttle Radar Topography Mission (SRTM) (~92 m resolution). The results obtained are in good agreement with the previous estimations based on seismic profiles and gravimetric modeling, with the exceptions of some particular locations. The results from the present method and those from the seismic interpretation are slightly different from the results of the gravimetric data. This discrepancy may result from the presence of large buried landslides in the bottom of the Rhone Valley.

[Voyage en Italie : 1824-1830]. , [Voie des Tombeaux : tombeau de la prêtresse Mamia] : [plan d'ensemble, profil de la base d'une colonne, coupe longitudinale sur le tombeau] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 448

Secretory IgA and intestinal epithelial cells at the interface between homeostasis regulation and protection against infection

RESUME DESTINE A UN LARGE PUBLICL'intestin est le siège d'intenses agressions de la part de l'ensemble des aliments ingérés, de bactéries agressives dites pathogènes mais également de bactéries dites commensales peuplant naturellement les surfaces intestinales muqueuses. Pour faire face, notre organisme arbore de nombreux niveaux de protections tant physiques, chimiques, mécaniques mais aussi immunitaires. La présence d'un type particulier de cellules, les cellules épithéliales (IEC) assurant une protection physique, ainsi que la production d'anticorps spécialisés par le système immunitaire appelés immunoglobulines sécrétoires A (SlgA) servent conjointement de première ligne de défense contre ces agressions externes. Néanmoins, comment le dialogue s'articule entre ces deux partenaires reste incomplet.Nous avons donc décidé de mimer ces interactions en modélisant les surfaces muqueuses par une monocouche de cellules différenciées en laboratoire. Des souches bactériennes isolées de l'intestin humain seules ou associées à des SlgA non-spécifiques ont été mises au contact de ce modèle cellulaire nous permettant de conclure quant à la présence effective d'une modulation du dialogue bactérie/lEC impliquant une activation de la réponse cellulaire vers un état de tolérance mutuelle. De façon surprenante, nous avons par ailleurs mis en évidence un type d'interaction nouveau entre ces anticorps et ces bactéries. Une étude biochimique nous a permis de détailler un nouveau rôle des SlgA médié par les sucres présents à leur surface dans le maintien d'une relation pacifique avec les commensaux perpétuellement présents, relations qualifiées d'homésostase intestinale.Le rôle protecteur des SlgA a par ailleurs été abordé pour avoir une meilleure appréhension de leur impact au niveau cellulaire lors d'infection par Shigella flexneri, bactérie causant la Shigellose, diarrhée sanglante responsable de la mort de plus d'un million de personnes chaque année. Basée sur le même modèle cellulaire, cette étude nous a permis de démontrer une nouvelle entrée de ce pathogène directement via les IEC. La présence d'anticorps spécifiques à la surface des bactéries restreint leur champs d'action contre les cibles intracellulaires identifiées que sont les filaments soutenant le squelette de la cellule, les fibres d'actine ainsi que les jonctions serrées, réseaux de protéines clés des interactions entre cellules. Cette ouverture au niveau cellulaire apporte un nouvel élan quant à la compréhension du rôle protecteur des SlgA lors d'attaques de l'intestin, protection semblant dépendante d'une agrégation des bactéries.Pour finir, nous avons mis en évidence la détection directe par les cellules de la présence d'anticorps libres dans l'intestin ajoutant une nouvelle réplique dans le dialogue complexe entre ces deux piliers de l'équilibre intestinal que sont les SlgA et les cellules épithéliales.RESUMELa muqueuse intestinale est dotée d'un réseau complexe de protections physico-chimiques, mécaniques ou immunologiques. Associées à un système immunitaire omniprésent, les cellules épithéliales intestinales {IEC) bordant la lumière intestinale ont la double tâche de protéger l'intérieur de l'organisme stérile contre l'invasion et la dissémination d'agents pathogènes, et de maintenir une relation pacifique avec la flore intestinale, rôles également joués par les immunoglobulines sécrétoires A (SlgA), anticorps les plus abondamment présents à la surface des muqueuses. Tant les IEC que les SlgA sont ainsi décrites comme convergeant vers le même objectif ; néanmoins, les rouages de leurs interactions restent largement inconnus.Pour répondre à cette question, des monocouches épithéliales reconstituées in vitro ont été incubées avec des souches commensales telles que des Lactobacillus ou des Bifodobacteria, seules ou complexées avec des SlgA non-spécifiques, nous permettant de décrypter l'influence des SlgA sur la détection des bactéries par les IEC, favorisant l'adhésion bactérienne et la cohésion cellulaire, augmentant l'activation de la voie NF-κΒ ainsi que la sécrétion de la cytokine thymic stromal lymphopoietin contrairement à celle de médiateurs pro-inflammatoires qui reste inchangée. Par ailleurs, une interaction Fab-indépendante est suggérée dans l'interaction SlgA/bactéries. Comme une interaction de faible affinité a été décrite comme prenant naturellement place au niveau de l'intestin, nous avons donc disséqué les mécanismes sous- jacents en utilisant un large spectre de bactérie associés à des protéines soit recombinantes soit isolées à partir de colostrum, mettant en évidence un rôle crucial des N-glycanes présents sur la pièce sécrétoire et soulignant une nouvelle propriété des SlgA dans l'homéostase intestinale.Intrinsèquement liés aux caractéristiques des SlgA, nous nous sommes également focalisés sur leur rôle protecteur lors d'infection par l'enteropathogène Shigella flexneri reproduites in vitro sur des monocouches polarisées. Nous avons tout d'abord démontré une nouvelle porte d'entrée pour ce pathogène directement via les IEC. L'agrégation des bactéries par les SlgA confère aux cellules une meilleure résistance à l'infection, retardant croissance bactérienne et entrée cellulaire, affectant par ailleurs leur capacité à cibler le cytosquelette et les jonctions serrées. La formation de tels cargos détectés de façon biaisée par les IEC apparaît comme une explication plausible au maintien de la cohésion cellulaire médiée par les SlgA.Enfin, le retrotransport des SlgA à travers les IEC a été abordé soulignant une participation active de ces cellules dans la détection de l'environnement extérieur, les impliquant possiblement dans l'activation d'un état muqueux stable.Conjointement, ces résultats indiquent que les SlgA représentent l'un des éléments-clés à la surface de la muqueuse et soulignent la complexité du dialogue établi avec l'épithélium en vue du maintien d'un fragile équilibre intestinal.ABSTRACTThe intestinal mucosa is endowed with a complex protective network melting physiochemical, mechanical and immunological features. Beyond the ubiquitous intestinal immune system, intestinal epithelial cells (IEC) lying the mucosal surfaces have also the dual task to protect the sterile core against invasion and dissemination of pathogens, and maintain a peaceful relationship with commensal microorganisms, aims also achieved by the presence of high amounts of secretory immunoglobulins A (SlgA), the most abundant immunoglobulin present at mucosal surfaces. Both IEC and SlgA are thus described to converge toward the same goal but how their interplay is orchestrated is largely unknown.To address this question, in vitro reconstituted IEC monolayers were first apically incubated with commensal bacteria such as Lactobacillus or Bifodobacteria strains either alone or in complexes with non-specific SlgA. Favoring the bacterial adhesion and cellular cohesion, SlgA impacts on the cellular sensing of bacteria, increasing NF-κΒ activation, and leading to cytokine releases restricted to the thymic stromal lymphopoietin and unaffected expression of pro-inflammatory mediators. Of main interest, bacterial recognition by SlgA suggested a Fab-independent interaction. As this low affinity, called natural coating occurs in the intestine, we further dissected the underlying mechanisms using a larger spectrum of commensal strains associated with recombinant as well as colostrum-derived proteins and pinpointed a crucial role of N-glycans of the secretory component, emphasizing an underestimated role of carbohydrates and another properties of SlgA in mediating intestinal homeostasis.As mucosal protection is also anchored in SlgA and IEC features, we focused on the cellular role of SlgA. Using IEC apical infection by the enteropathogen Shigella flexneri, we have first demonstrated a new gate of entry for this pathogen directly via IEC. Specific SlgA bacterial aggregation conferred to the cells a better resistance to infection, delaying bacterial growth and cellular entry, affecting their ability to damage both the cytoskeleton and the tight junctions. Formation of such big cargos differentially detected by IEC appears as a plausible explanation sustaining at the cellular level the antibody-mediated mucosal protection.Finally, SlgA retrotransport across IEC has been tackled stressing an active IEC sensing of the external environment possibly involved in the steady-state mucosal activation.All together, these results indicate that SlgA represents one of the pivotal elements at mucosal surfaces highlighting the complexity of the dialogue established with the epithelium sustaining the fragile intestinal balance.The Intestinal mucosa is endowed with a complex protective network melting physiochemical, mechanical and immunological features. Beyond the ubiquitous intestinal immune system, intestinal epithelial cells (IEC) lying the mucosal surfaces have also the dual task to protect the sterile core against invasion and dissemination of pathogens, and maintain a peaceful relationship with commensal microorganisms, aims also achieved by the presence of high amounts of secretory immunoglobulins A (SlgA), the most abundant immunoglobulin present at mucosal surfaces. Both IEC and SlgA are thus described to converge toward the same goal but how their interplay is orchestrated is largely unknown.To address this question, in vitro reconstituted IEC monolayers were first apically incubated with commensal bacteria such as Lactobacillus or Bifodobacteria strains either alone or in complexes with non-specific SlgA. Favoring the bacterial adhesion and cellular cohesion, SlgA impacts on the cellular sensing of bacteria, increasing NF-κΒ activation, and leading to cytokine releases restricted to the thymic stromal lymphopoietin and unaffected expression of pro-inflammatory mediators. Of main interest, bacterial recognition by SlgA suggested a Fab-independent interaction. As this low affinity, called natural coating occurs in the intestine, we further dissected the underlying mechanisms using a larger spectrum of commensal strains associated with recombinant as well as colostrum-derived proteins and pinpointed a crucial role of N-glycans of the secretory component, emphasizing an underestimated role of carbohydrates and another properties of SlgA in mediating intestinal homeostasis.As mucosal protection is also anchored in SlgA and IEC features, we focused on the cellular role of SlgA. Using IEC apical infection by the enteropathogen Shigella flexneri, we have first demonstrated a new gate of entry for this pathogen directly via IEC. Specific SlgA bacterial aggregation conferred to the cells a better resistance to infection, delaying bacterial growth and cellular entry, affecting their ability to damage both the cytoskeleton and the tight junctions. Formation of such big cargos differentially detected by IEC appears as a plausible explanation sustaining at the cellular level the antibody-mediated mucosal protection.Finally, SlgA retrotransport across IEC has been tackled stressing an active IEC sensing of the external environment possibly involved in the steady-state mucosal activation.All together, these results indicate that SlgA represents one of the pivotal elements at mucosal surfaces highlighting the complexity of the dialogue established with the epithelium sustaining the fragile intestinal balance.

[Voyage en Italie : 1824-1830]. , Cour du Palais de Venise, à Rome. Détails de la Cour, 1er Etage. Au dixième de l'Exécution : [élévations frontale et latérale d'une colonne (base et chapiteau) et de l'entablement, détail d'une clef] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 584

[Voyage en Italie : 1824-1830]. , Cour du Palais de Venise, à Rome. Détails de la Cour, rez de chaussée. Au dixième de l'Exécution : [élévations frontale et latérale d'une colonne (base et chapiteau) et de l'entablement, détail d'une clef] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 583