Teknologian tulevaisuuden näkymiä

Kirjallisuusarvostelu

Tärkeä tutkimus näkövammaisten historiasta

Kirjallisuusarvostelu

Viitekehyksen kehitys, kehykseen perustuvat tutkimukset ja niiden anti : case: Levers of Control

Tutkielmassa tarkastellaan yrityksen strategian ja ohjauksen yhdistävän Levers of Control -viitekehyksen syntymistä ja kehittymistä nykyiseen muotoonsa. Lisäksi tutkimus perehtyy viitekehystä hyödyntävien tieteellisten tutkimusten antiin strategian ja ohjausjärjestelmien ymmärtämisessä sekä näiden tutkimusten antia itse viitekehykselle. Tutkielma on luonteeltaan käsiteanalyyttinen, analysoiden aiheesta julkaistua aikaisempaa kirjallisuutta. Kirjallisuus on rajattu viitekehyksen kehittäjän Robert Simonsin aiheesta kirjoittamaan materiaaliin sekä eri journaaleista löytyvään viitekehystä hyödyntävään aineistoon. Vaikka viitekehys on luotu myös käytännön toimijoiden avuksi, on tähän liittyvä aineisto kuitenkin rajattu tässä tutkielmassa pois tarkastelusta. Viitekehyksen kehityksen havaitaan noudattavan hermeneuttisen kehän piirteitä, sillä kehityksessä voidaan nähdä neljä erilaista vaihetta: esiymmärrys, esikehys, idea viitekehyksestä ja varsinaisen viitekehyksen vaihe. Kutakin näistä kehistä analysoidaan erikseen ja kaikkia vielä yhdessä. Havaitaan myös, että viitekehyksestä käyty vähäinen diskurssi on pääosin positiivista tunnustaen viitekehyksen ansiot mutta myös ongelmat myönnetään. Viitekehysanalyysin jälkeen siirrytään tarkastelemaan viitekehystä hyödyntävää materiaalia. Huomataan, että nämä tutkimusartikkelit voidaan luokitella neljään pääkategoriaan: empiriapohjaisiin, viitekehystä teoreettisesti hyödyntäviin, viitekehystä kehittämään pyrkiviin sekä opetustarkoituksessa kirjoitettuihin artikkeleihin. Näitä pääkategorioita analysoidaan usein eri tavoin erillisinä sekä yhtenä kokonaisuutena. Eri tutkimusartikkeleiden tuloksia on hankala kuitenkin yhdistää viitekehyksessä olevan ongelman takia: useimpien käytännön pohjalta luotujen selitysmallien tapaan Levers of Control –viitekehyksen käsitteet eivät ole yksiselitteisiä ja sama ongelma on nähtävissä myös viitekehystä hyödyntäneissä tutkimuksissa. Joitakin suuntaa antavia tuloksia interaktiivisuuden roolista ja dynaamisesta jännitteestä voidaan kuitenkin tehdä. Tiedeyhteisö ei ole hyväksynyt Levers of Control –viitekehystä varsinaiseksi teoriaksi. Tutkielmassa todetaan, että teoria-statuksen saaminen ei ole mahdotonta, mutta teoriaksi nousemiseen viitekehyksellä on kuitenkin vielä reilusti matkaa. Ennen sitä on havaitut ongelmat kyettävä ratkaisemaan ja löydettävä hyödyntämisen rajat. Ensimmäisiä askeleita tähän suuntaan ovat viitekehystä hyödyntämään pyrkivät tutkimusartikkelit pyrkineet jo kuitenkin ottamaan. Tutkielmassa tullaan siihen loppupäätelmään, että viitekehys on tällä hetkellä kehityskaarensa toisessa vaiheessa, sillä viitekehystä koskeva kirjoittelu keskittyy perustutkimukseen, arvolatautuneen kriittisen tutkimuksen puuttuessa vielä kokonaan.

Sosiaalinen romaani, yhteiskuntaromaani ja niiden lajisukulaiset kirjallisuushistorian ja nykykirjallisuuden kerrostumana

Sellaiset ilmaisut kuin ”sosiaalinen romaani” ja ”yhteiskunnallinen romaani” toistuvat nykykirjallisuutta koskevissa luonnehdinnoissa. Luonnehdintoja ei tavallisesti perustella lajiteorioiden avulla, eikä niissä ole tapana viitata sosiaalisen romaanin ja yhteiskuntaromaanin lajihistorioihin. Artikkeli tarkastelee sosiaalisen romaanin ja yhteiskuntaromaanin lajikategorioiden yleistymistä ja niiden myöhempää kehitystä eu-rooppalaisessa ja suomalaisessa kirjallisuudessa 1800-luvulla ja 1900-luvulla. Lisäksi se analysoi lajien nykyisten suomalaisten edustajien – Kari Hotakaisen, Tommi Melenderin, Hannu Raittilan, Arto Salmi-sen ja Juha Seppälän – tuotantoa.

Host Parasite Interactions in Damselflies. From Individuals to Populations

The main goal of this thesis is to increase understanding on evolutionary and ecological factors that have contributed to differences in parasite numbers in insects. Furthermore, the thesis addresses the effects of parasites on their hosts. The most important findings were: The Northern damselfly’s (Coenagrion hastulatum) immune response to artificial pathogen increased with increasing parasite numbers (Article I). Marginal, more isolated C. hastulatum populations on the edge of distribution have fewer parasites when compared to distribution’s core populations (Article II). The Banded damselfly Calopteryx splendens individuals with higher homozygosity have more parasites, however, the rate of homozygosity did not differ between populations (Article III). Parasite prevalence was affected by whether the host species occurred in allopatric or sympatric population: sympatric C. splendens populations with sister species the Beautiful damselfly Calopteryx virgo harbored more parasites (Article IV). Parasites were associated with the wing spot size, an ornament under sexual selection, and thus may play an important role in character displacement, i.e. the size of the wing spot (Article V). To conclude with, this thesis brings about new information on the parasite infection patterns in insects, proposing several factors to contribute to these patters, as well as it addresses the effects of parasites on their hosts, from individual to population level.

ERBB4 mutations in cancer and amyotrophic lateral sclerosis

ErbB receptor tyrosine kinases, epidermal growth factor receptor (EGFR, also known as ErbB1), ErbB2 (HER2 or NEU), ErbB3 (HER3), and ErbB4 (HER4), transduce signals borne by extracellular ligands into central cellular responses such as proliferation, survival, differentiation, and apoptosis. Mutations in ERBB genes are frequently detected in human malignant diseases of epithelial and neural origin, making ErbB receptors important drug targets. Targeting EGFR and ErbB2 has been successful in eg. lung and breast cancer, respectively, and mutations in these genes can be used to select patients that are responsive to the targeted treatment. Although somatic ERBB4 mutations have been found in many high-incidence cancers such as melanoma, lung cancer, and colorectal cancer and germ-line ERBB4 mutations have been linked to neuronal disorders and cancer, ErbB4 has generally been neglected as a potential drug target. Thus, the consequences of ERBB4 mutations on ErbB4 biology are largely unknown. This thesis aimed to elucidate the functional consequences and assess the clinical significance of somatic and germ-line ERBB4 mutations in the context of cancer and amyotrophic lateral sclerosis. The results of this study indicated that cancer-associated ERBB4 mutations can promote aberrant ErbB4 function by activating the receptor or inducing qualitative changes in ErbB4 signaling. ERBB4 mutations increased survival or decreased differentiation in vitro, suggesting that ERBB4 mutations can be oncogenic. Importantly, the potentially oncogenic mutations were located in various subdomains in ErbB4, possibly providing explanation for the characteristic scattered pattern of mutations in ERBB4. This study also demonstrated that hereditary variation in ERBB4 gene can have a significant effect on the prognosis of breast cancer. In addition, it was shown that hereditary or de novo germ-line ERBB4 mutations that predispose to amyotrophic lateral sclerosis inhibit ErbB4 activity. Together, these results suggest that ErbB4 should be considered as a novel drug target in cancer and amyotrophic lateral sclerosis.

Arkistoluettelo 760: Jean Sibelius

Luettelo Jean Sibeliuksen käsikirjoituksista, jotka ovat tulleet Kansalliskirjastoon varsinaisen arkistoluettelon (Arkistoluettelo 216: The Jean Sibelius musical manuscripts at Helsinki University Library / Kari Kilpeläinen) tekemisen jälkeen

Value of Information Logistics Integration in Digital Business Ecosystem

Digital business ecosystems (DBE) are becoming an increasingly popular concept for modelling and building distributed systems in heterogeneous, decentralized and open environments. Information- and communication technology (ICT) enabled business solutions have created an opportunity for automated business relations and transactions. The deployment of ICT in business-to-business (B2B) integration seeks to improve competitiveness by establishing real-time information and offering better information visibility to business ecosystem actors. The products, components and raw material flows in supply chains are traditionally studied in logistics research. In this study, we expand the research to cover the processes parallel to the service and information flows as information logistics integration. In this thesis, we show how better integration and automation of information flows enhance the speed of processes and, thus, provide cost savings and other benefits for organizations. Investments in DBE are intended to add value through business automation and are key decisions in building up information logistics integration. Business solutions that build on automation are important sources of value in networks that promote and support business relations and transactions. Value is created through improved productivity and effectiveness when new, more efficient collaboration methods are discovered and integrated into DBE. Organizations, business networks and collaborations, even with competitors, form DBE in which information logistics integration has a significant role as a value driver. However, traditional economic and computing theories do not focus on digital business ecosystems as a separate form of organization, and they do not provide conceptual frameworks that can be used to explore digital business ecosystems as value drivers—combined internal management and external coordination mechanisms for information logistics integration are not the current practice of a company’s strategic process. In this thesis, we have developed and tested a framework to explore the digital business ecosystems developed and a coordination model for digital business ecosystem integration; moreover, we have analysed the value of information logistics integration. The research is based on a case study and on mixed methods, in which we use the Delphi method and Internetbased tools for idea generation and development. We conducted many interviews with key experts, which we recoded, transcribed and coded to find success factors. Qualitative analyses were based on a Monte Carlo simulation, which sought cost savings, and Real Option Valuation, which sought an optimal investment program for the ecosystem level. This study provides valuable knowledge regarding information logistics integration by utilizing a suitable business process information model for collaboration. An information model is based on the business process scenarios and on detailed transactions for the mapping and automation of product, service and information flows. The research results illustrate the current cap of understanding information logistics integration in a digital business ecosystem. Based on success factors, we were able to illustrate how specific coordination mechanisms related to network management and orchestration could be designed. We also pointed out the potential of information logistics integration in value creation. With the help of global standardization experts, we utilized the design of the core information model for B2B integration. We built this quantitative analysis by using the Monte Carlo-based simulation model and the Real Option Value model. This research covers relevant new research disciplines, such as information logistics integration and digital business ecosystems, in which the current literature needs to be improved. This research was executed by high-level experts and managers responsible for global business network B2B integration. However, the research was dominated by one industry domain, and therefore a more comprehensive exploration should be undertaken to cover a larger population of business sectors. Based on this research, the new quantitative survey could provide new possibilities to examine information logistics integration in digital business ecosystems. The value activities indicate that further studies should continue, especially with regard to the collaboration issues on integration, focusing on a user-centric approach. We should better understand how real-time information supports customer value creation by imbedding the information into the lifetime value of products and services. The aim of this research was to build competitive advantage through B2B integration to support a real-time economy. For practitioners, this research created several tools and concepts to improve value activities, information logistics integration design and management and orchestration models. Based on the results, the companies were able to better understand the formulation of the digital business ecosystem and the importance of joint efforts in collaboration. However, the challenge of incorporating this new knowledge into strategic processes in a multi-stakeholder environment remains. This challenge has been noted, and new projects have been established in pursuit of a real-time economy.