Deep-sea benthic footprint of the Deepwater Horizon blowout

The Deepwater Horizon (DWH) accident in the northern Gulf of Mexico occurred on April 20, 2010 at a water depth of 1525 meters, and a deep-sea plume was detected within one month. Oil contacted and persisted in parts of the bottom of the deep-sea in the Gulf of Mexico. As part of the response to the accident, monitoring cruises were deployed in fall 2010 to measure potential impacts on the two main soft-bottom benthic invertebrate groups: macrofauna and meiofauna. Sediment was collected using a multicorer so that samples for chemical, physical and biological analyses could be taken simultaneously and analyzed using multivariate methods. The footprint of the oil spill was identified by creating a new variable with principal components analysis where the first factor was indicative of the oil spill impacts and this new variable mapped in a geographic information system to identify the area of the oil spill footprint. The most severe relative reduction of faunal abundance and diversity extended to 3 km from the wellhead in all directions covering an area about 24 km2. Moderate impacts were observed up to 17 km towards the southwest and 8.5 km towards the northeast of the wellhead, covering an area 148 km2. Benthic effects were correlated to total petroleum hydrocarbon, polycyclic aromatic hydrocarbons and barium concentrations, and distance to the wellhead; but not distance to hydrocarbon seeps. Thus, benthic effects are more likely due to the oil spill, and not natural hydrocarbon seepage. Recovery rates in the deep sea are likely to be slow, on the order of decades or longer.

Modeling red sea urchin (Strongylocentrotus franciscanus) growth using six growth functions

The growth of red sea urchins (Strongylocentrotus franciscanus) was modeled by using tag-recapture data from northern California. Red sea urchins (n=211) ranging in test diameter from 7 to 131 mm were examined for changes in size over one year. We used the function Jt+1 = Jt + f(Jt) to model growth, in which Jt is the jaw size (mm) at tagging, and Jt+1 is the jaw size one year later. The function f(Jt), represents one of six deterministic models: logistic dose response, Gaussian, Tanaka, Ricker, Richards, and von Bertalanffy with 3, 3, 3, 2, 3, and 2 minimization parameters, respectively. We found that three measures of goodness of fi t ranked the models similarly, in the order given. The results from these six models indicate that red sea urchins are slow growing animals (mean of 7.2 ±1.3 years to enter the fishery). We show that poor model selection or data from a limited range of urchin sizes (or both) produces erroneous growth parameter estimates and years-to-fishery estimates. Individual variation in growth dominated spatial variation at shallow and deep sites (F=0.246, n=199, P=0.62). We summarize the six models using a composite growth curve of jaw size, J, as a function of time, t: J = A(B – e–Ct) + Dt, in which each model is distinguished by the constants A, B, C, and D. We suggest that this composite model has the flexibility of the other six models and could be broadly applied. Given the robustness of our results regarding the number of years to enter the fishery, this information could be incorporated into future fishery management plans for red sea urchins in northern California.

Reconstruction of aridity for the Sierra de la Laguna, Baja California Sur, Mexico

A well-documented history of past climatic conditions is needed to understand and resolve some ecological problems, but the existing climatological records are too short to detect long-term climatic variability and changes. Some trees, such as pines, produce annual tree rings with different widths depending on prevailing environmental conditions, such as climate. Tree-ring analysis of long-lived trees can be used to estimate past variations in climate. The principal aim of this study is to reconstruct aridity for the southern portion of the Baja California Peninsula, by means of dendroclimatologic techniques.

Ictiólogos de la Argentina: María de los Ángeles Bistoni.

En esta serie se mencionan a todos aquellos que, a través de sus pequeños o grandes aportes, contribuyeron a la consolidación de la disciplina en nuestro país. El plan general de esta contribución consiste en la elaboración de fichas individuales que contengan una lista de trabajos de los diferentes autores, acompañadas por bibliografía de referencia y, cuando ello fuera posible, por imágenes personales y material adicional. Se tratará de guardar un orden cronológico, pero esto no es excluyente, ya que priorizaremos las sucesivas ediciones al material disponible. Este es otro camino para rescatar y revalorizar a quienes en diversos contextos históricos sentaron las bases de lo que hoy es la ictiología nacional. Considero que este es el comienzo de una obra de mayor magnitud en la que se logre describir una parte importante de la historia de las ciencias naturales de la República Argentina.

Sistemas silvipastoris para bovinos e ovinos.

A eficiência econômica e os impactos sociais e ambientais do atual modelo de agricultura têm sido questionados em muitos aspectos. Sistemas silvipastoris (SSPs) são sistemas de produção nos quais forrageiras e/ou animais e árvores são cultivados, simultânea ou sequencialmente, na mesma unidade de área. A ideia de integrar animais nas atividades florestais já existe em várias partes do mundo, principalmente na Ásia, África, América Central e alguns países da América Latina. Estudos demonstraram a lucratividade dos SSPs por meio da comparação de sistemas de monocultura de floresta, monocultura de pastagens e SSP com 250 e 416 árvores por hectare, e esse sistema apresentou as maiores taxas internas de retorno (TIR) do investimento efetuado, superando a renda líquida obtida nas monoculturas. Além dos benefícios econômicos, esses sistemas trazem benefícios ambientais, por meio da conservação do solo, alívio à pressão em remanescentes vegetais, melhoria nos ciclos de nutrientes, como C e N, alteração microclimáticas com amenização dos extremos, estagnação de processos erosivos, e também sociais pelo aumento da geração de emprego e distribuição da renda das propriedades rurais. De toda a gama de incrementos gerados pelos SSPs, os maiores beneficiados são, de fato, os animais que, quando criados em consórcio com árvores, gozam de melhor alimentação, mais proteção a intempéries climáticas e amenização das temperaturas, sofrendo assim menor estresse e produzindo produtos de melhor qualidade. Desta forma, sempre que tais sistemas forem bem delineados, desde a escolha das espécies até o modelo de implantação, sempre haverá grande chance de sucesso e consequente melhorias para a comunidade envolvida.

Estabelecimento de espécies arbóreas de cerrados em função do manejo de Brachiaria sp.

Neste estudo teve-se como objetivo avaliar a emergência, o recrutamento e crescimento de sete leguminosas arbóreas dos Cerrados em áreas de pastagem abandonadas, a partir de semeadura direta, sob diferentes regimes de manejo de Brachiaria sp.

Prediction of 30-day mortality in older patients with a first acute myocardial infarction

This study sought predictors of mortality in patients aged >or=75 years with a first ST-segment elevation myocardial infarction (STEMI) and evaluated the validity of the GUSTO-I and TIMI risk models. Clinical variables, treatment and mortality data from 433 consecutive patients were collected. Univariable and multivariable logistic regression analyses were applied to identify baseline factors associated with 30-day mortality. Subsequently a model predicting 30-day mortality was created and compared with the performance of the GUSTO-I and TIMI models. After adjustment, a higher Killip class was the most important predictor (OR 16.1; 95% CI 5.7-45.6). Elevated heart rate, longer time delay to admission, hyperglycemia and older age were also associated with increased risk. Patients with hypercholesterolemia had a significantly lower risk (OR 0.46; 95% CI 0.24-0.86). Discrimination (c-statistic 0.79, 95% CI 0.75-0.84) and calibration (Hosmer-Lemeshow 6, p = 0.5) of our model were good. The GUSTO-I and TIMI risk scores produced adequate discrimination within our dataset (c-statistic 0.76, 95% CI 0.71-0.81, and c-statistic 0.77, 95% CI 0.72-0.82, respectively), but calibration was not satisfactory (HL 21.8, p = 0.005 for GUSTO-I, and HL 20.6, p = 0.008 for TIMI). In conclusion, short-term mortality in elderly patients with a first STEMI depends most importantly on initial clinical and hemodynamic status. The GUSTO-I and TIMI models are insufficiently adequate for providing an exact estimate of 30-day mortality risk.

Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship

α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring.

'Adipaging': Aging and obesity share biological hallmarks related to a dysfunctional adipose tissue

The increasing aging of our societies is accompanied by a pandemic of obesity and related cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is increasingly recognized as an important hallmark of the aging process which in turn contributes to metabolic alterations, multi-organ damage, and a systemic pro-inflammatory state ('inflammaging'). On the other hand, obesity, the paradigm of adipose tissue dysfunction, shares numerous biological similarities with the normal aging process such as chronic inflammation and multi-system alterations. Accordingly, understanding the interplay between accelerated aging related to obesity and adipose tissue dysfunction is critical to gain insight into the aging process in general as well as into the pathophysiology of obesity and other related conditions. Here we postulate the concept of 'adipaging' to illustrate the common links between aging and obesity and the fact that, to a great extent, obese adults are prematurely aged individuals.

Muscle signaling in exercise intolerance: Insights from the McArdle mouse model

We recently generated a knock-in mouse model (PYGM p.R50X/p.R50X) of McArdle disease (myophosphorylase deficiency). One mechanistic approach to unveil the molecular alterations caused by myophosphorylase deficiency, which is arguably the paradigm of 'exercise intolerance', is to compare the skeletal-muscle tissue of McArdle, heterozygous, and healthy (wild type (wt)) mice. We analyzed in quadriceps muscle of p.R50X/p.R50X (n=4), p.R50X/wt (n=6) and wt/wt mice (n=5) (all male, 8 wk-old) molecular markers of energy-sensing pathways, oxidative phosphorylation (OXPHOS) and autophagy/proteasome systems, oxidative damage and sarcoplamic reticulum (SR) Ca handling. We found a significant group effect for total AMPK (tAMPK) and ratio of phosphorylated (pAMPK)/tAMPK (P=0.012 and 0.033), with higher mean values in p.R50X/p.R50X mice vs. the other two groups. The absence of massive accumulation of ubiquitinated proteins, autophagosomes or lysosomes in p.R50X/p.R50X mice suggested no major alterations in autophagy/proteasome systems. Citrate synthase activity was lower in p.R50X/p.R50X mice vs. the other two groups (P=0.036) but no statistical effect existed for respiratory chain complexes. We found higher levels of 4-hydroxy-2-nonenal-modified proteins in p.R50X/p.R50X and p.R50X/wt mice compared with the wt/wt group (P=0.011). Sarco(endo)plasmic reticulum ATPase 1 (SERCA1) levels detected at 110kDa tended to be higher in p.R50X/p.R50X and p.R50X/wt mice compared with wt/wt animals (P=0.076), but their enzyme activity was normal. We also found an accumulation of phosphorylated SERCA1 in p.R50X/p.R50X animals. Myophosphorylase deficiency causes alterations in sensory energetic pathways together with some evidence of oxidative damage and alterations in Ca handling but with no major alterations in OXPHOS capacity or autophagy/ubiquitination pathways, which suggests that the muscle tissue of patients is likely to adapt overall favorably to exercise training interventions.

Children drawing toy commercials: re-imagining television production features

Griffiths, M. (2005). Children drawing toy commercials: re-imagining television production features. Visual Communication. 4(1), pp.21-37. RAE2008

Pink Worlds and Blue Worlds: A Portrait of Intimate Polarity

Griffiths, Merris, 'Pink Worlds and Blue Worlds: A Portrait of Intimate Polarity', In: 'Small Screens: television for children', D. Buckingham (Ed.), (London: Leicester University Press), pp. 159-184, 2002 RAE2008

Media Literacy in Wales: a Critical Review of Industry and Education Policies

Griffiths, L.; and O'Malley, T. (2007). Media Literacy in Wales: a Critical Review of Industry and Education Policies. Cyfrwng. 4, pp.7-23. RAE2008