Reduced ejection fraction after myocardial infarction: is it sufficient to justify implantation of a defibrillator?

BACKGROUND: Improved survival after prophylactic implantation of a defibrillator in patients with reduced left ventricular ejection fraction (EF) after myocardial infarction (MI) has been demonstrated in patients who experienced remote MIs in the 1990s. The absolute survival benefit conferred by this recommended strategy must be related to the current risk of arrhythmic death, which is evolving. This study evaluates the mortality rate in survivors of MI with impaired left ventricular function and its relation to pre-hospital discharge baseline characteristics. METHODS: The clinical records of patients who had sustained an acute MI between 1999 and 2000 and had been discharged from the hospital with an EF of < or = 40% were included. Baseline characteristics, drug prescriptions, and invasive procedures were recorded. Bivariate and multivariate analyses were performed using a primary end point of total mortality. RESULTS: One hundred sixty-five patients were included. During a median follow-up period of 30 months (interquartile range, 22 to 36 months) 18 patients died. The 1-year and 2-year mortality rates were 6.7% and 8.6%, respectively. Variables reflecting coronary artery disease and its management (ie, prior MI, acute reperfusion, and complete revascularization) had a greater impact on mortality than variables reflecting mechanical dysfunction (ie, EF and Killip class). CONCLUSIONS: The mortality rate among survivors of MIs with reduced EF was substantially lower than that reported in the 1990s. The strong decrease in the arrhythmic risk implies a proportional increase in the number of patients needed to treat with a prophylactic defibrillator to prevent one adverse event. The risk of an event may even be sufficiently low to limit the detectable benefit of defibrillators in patients with the prognostic features identified in our study. This argues for additional risk stratification prior to the prophylactic implantation of a defibrillator.

Interpretación en los servicios públicos en el ámbito sanitario en la provincia de Barcelona

El nostre treball pretén observar com estan organitzats els serveis de TISSPP de l'àmbit sanitari de Barcelona. Amb aquesta finalitat, realitzem una observació indirecta detallada mitjançant entrevistes semi-estructurades tant a professionals de la salut, com al personal encarregat de gestionar aquests serveis. Els resultats obtinguts ens van permetre de descriure en què consisteixen els serveis de TISSPP dels centres estudiats, quin és el perfil dels seus usuaris, dels seus prestataris i dels professionals de la salut que els utilitzen. Així mateix, descrivim com s'està duent a terme la pràctica de la TISSPP i quina avaluació rep

Sex determination: why so many ways of doing it?

Sexual reproduction is an ancient feature of life on earth, and the familiar X and Y chromosomes in humans and other model species have led to the impression that sex determination mechanisms are old and conserved. In fact, males and females are determined by diverse mechanisms that evolve rapidly in many taxa. Yet this diversity in primary sex-determining signals is coupled with conserved molecular pathways that trigger male or female development. Conflicting selection on different parts of the genome and on the two sexes may drive many of these transitions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studied. Here we survey our current understanding of how and why sex determination evolves in animals and plants and identify important gaps in our knowledge that present exciting research opportunities to characterize the evolutionary forces and molecular pathways underlying the evolution of sex determination.

Phylogenetic Code in the Cloud - Can it Meet the Expectations?

Cloud computing has recently become very popular, and several bioinformatics applications exist already in that domain. The aim of this article is to analyse a current cloud system with respect to usability, benchmark its performance and compare its user friendliness with a conventional cluster job submission system. Given the current hype on the theme, user expectations are rather high, but current results show that neither the price/performance ratio nor the usage model is very satisfactory for large-scale embarrassingly parallel applications. However, for small to medium scale applications that require CPU time at certain peak times the cloud is a suitable alternative.

All-Ireland Health Data Inventory. Part 1: Metadata for key data sources, version 1.0

The All-Ireland Health Data Inventory. Part 1 is a catalogue of key sources of health data in the Republic and Northern Ireland. It includes relevant datasets from the major information reviews, conducted in the North and South, in the past few years. Information is essential for informed decision making and service provision. This inventory draws together information sources to facilitate such decision making. The inventory is intended as a resource for health professionals, researchers and the general public, providing the first phase of a ‘one-stop’ catalogue of health data. The datasets have been catalogued using an expanding numbering system which will allow for the inclusion of future resources. The Institute of Public Health in Ireland is in the process of expanding the Inventory to include further data sources.

Seminar Report: Translating Research into Better Public Health: What Does it Mean for the CoE(NI)?

The workshop was attended by 13 people excluding facilitators. Most were from outside QUB (including Belfast City Council, NHSSB, BHSCT, Centre for Public Health, NICR, Institute of Agri-food and Land Use (QUB), etc).Programme was:Introductions Part 1: What’s “knowledge brokerage” all about?Presentation and Q&A (Kevin Balanda)Small group discussions Part 2: What the Centre of Excellence is doingPresentation and Q&A (Kevin Balanda)Small group discussions

Disseny i desenvolupament d'un sistema de gestió de les comunitats de veïns

Les comunitats de veïns i els seus problemes han evolucionat molt el darrer segle; la impossibilitat de trobar un horari de reunió comú compatible, la falta de temps per a realitzar tasques administratives o la desinformació en l’àmbit jurídic en són exemples. Aquest projecte presenta una solució adaptada a aquestes necessitats basada en una eina TIC de gestió de comunitats que estalviarà temps i diners a veïns i professionals, posant a l’abast la informació i els diferents recursos relatius a la gestió de la comunitat en qualsevol lloc i moment, automatitzant part del procés administratiu dels gestors de comunitats