Blood pressure loci identified with a gene-centric array.

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 × 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.

Recueil de lettres et de pièces originales, et de copies de pièces indiquées comme telles dans le dépouillement qui suit.

Contient : 1 Lettre de « CATERINE [DE MEDICIS]... à monsieur de Mommorenscy » ; 2 Lettre de « CATERINE [DE MEDICIS]... à monseigneur le duc de Monmorency, pair et connestable de France... Escript à Sainct Maur des Fossés, le XXIme jour de jung » ; 3 « Memoire signé de la main du roy [CHARLES IX], qui avoit esté baillé au Sr de Combault par les depputez de Sa Majesté par elle responduz, le XXVIe jour de mars 1568 » ; 4 « L'Original de la paix d'entre le roy et la royne d'Angleterre... Faict à Troye, le XIIIe jour d'apvril l'an mil V.C. soixante quatre, apres Pasques » ; 5 « Les Articles de la composition du Havre... Le vingt et huictiesme jour de juillet, l'an mil V.C. soixante et troys » ; 6 « Les Articles que demande monseigneur le connestable [Anne de Montmorency] à monseigneur le conte de Warvich », touchant la capitulation du Havre ; 7 « Memoire de ce qu'il fault demander aux Angloys », touchant la capitulation du Havre ; 8 « Declaration de guerre faite à Henry second par un heraut de Marie, reine d'Angleterre. 1557 » ; 9 Liberté sous condition accordée au Sr « de Trokmorton », prisonnier en France ; 10 « Les Articles de la composicion de la redicion du Havre... Le vingt huictme jour de juillet, l'an mil cinq cens soixante et trois » ; 11 Lettre du « conte DE... WARWYCK,... à monseigneur le connestable de France... Du Havre, ce XXXe jeuillet 1563 » ; 12 Lettre de « monsieur l'admiral d'Angleterre... HOWARD,... à monsieur le connestable de France... 7bre 1557 » ; 13 Lettre du « conte de... WARWYCK,... à monseigneur le connestable de France... Escrit à Windesore, le XVIIe d'aoust 1563 » ; 14 Liberté rendue à « Henry Killegrene », sur promesses du « Sr de Rethington,... à la royne, mere du roy... A Paris, le XXme jour de may, l'an M.V.C. soixante trois » ; 15 « Double de la lectre escripte par monsieur le conte DE WARVIC à monseigneur le conte Ringrave,... Du Havre de Grace, ce XXVIe jour de juillet 1563 » ; 16 Lettre du « conte DE WARWYCK,... à monseigneur le connestable de France... Du Havre, ce XXXme de juillet 1563 » ; 17 « Articles contre les soldatz du Havre de Grace. 1563 » ; 18 « Responce faicte sur le differend du territoire qui est entre l'Excluse, Doye et Gravelines » ; 19 « Departement des compagnies de la gendarmerie, ensemble des commissaires et contrerolleurs ordinaires des guerres ordonnez pour en faire la monstre pour le quartier d'octobre, novembre et decembre... Faict à Fontainebleau, le XXVIme jour de fevrier 1560 ». Signé : « MONTMORENCY » ; 20 « Gens d'armes » ; 21 « Estat des deniers revenans bons au roy de sa gendarmerie de la monstre faicte en armes, le premier jour de juin M.V.C.LXVII, pour les quartiers de janvier et avril de ladicte année » ; 22 « Departement des compaignyes de la gendarmerie et des lieux où elles sont de present en garnison » ; 23 « Estat abregé des compaignies de la gendarmerye de France pour l'année finie en decembre 1565 » ; 24 Lettre de « PHILIPPE STROSSE,... à monsieur le mareschal de Montmorency,... De Paris, ce cinquieme de juin 1563 » ; 25 Lettre du Sr « SAINTSUPLICE,... à monseigneur le mareschal de Monmorancy,... De Madrid, aoust 1563 » ; 26 Lettre de « CLAUDE [DE SAVOIE, comte] DE TANDE,... à monseigneur... le connestable de France... A Villeneuve, le XXVme de novembre 1563 » ; 27 Lettre de « H[ENRI] DE MONTMORANCY [seigneur, DE DAMVILLE]... à monsieur mon frere, monsieur le duc de Montmorency, pair et mareschal de France... De Thoulouse, ce XIIe mars 1570 » ; 28 Lettre de « H[ENRI] DE MONTMORENCY,... à monsieur de Montmorency, marechal de France... De Bruxelles, ce XIX de mars 1563 » ; 29 Lettre de JEAN D'HEMERI, seigneur DE « VILLARZ,... à madame la connestable, duchesce de Montmorency » ; 30 Lettre de SIMON DE « FIZES [baron DE SAUVES, secrétaire d'État]... à monseigneur le duc de Montmorancy,... Escript à Paris, ce XXVIme jour de may » ; 31 Mesures prises pour une entrevue de « monseigneur le prince de Condé et monsieur le conestable » ; 32 « Forme d'apointemant proposé par messieurs les mareschaulx de Vielleville et de Bourdillon,... pour mettre une bonne fin aux choses passées entre messieurs les cardinal de Lorraine, duc de Guyse et mareschal de Montmorancy » ; 33 Lettre inachevée, relative à la publication de la paix ; 34 « Double d'une lectre de messeigneurs DE MONTMORANCY et DE MORVILLIER, du Ve mars 1568, estans à Paris, adressante à messrs de Lymoges et d'Alluye » ; 35 Chiffre ; 36 « Double d'une lectre de la royne à monseigneur le duc de Montmorancy estant à Longjumeau pour la negociation de la paix... De Paris, le premier jour de mars 1568 » ; 37 « Double d'une lectre du roy... adressante à messieurs de Morviller, de Lymoges et d'Alluye,... De Paris, ce Vme mars 1568 » ; 38-39 Deux lettres de CHARLES IX ; 40 Copie de lettres closes du roi CHARLES IX. « A Paris... 1568 » ; 41 Lettre de « VOLPERT VON DERSZ,... à monseigneur le connestable... De Montirandel, ce XXVe jour de may 1563 » ; 42 « Promesse faicte par monsieur l'amyral [GASPARD DE COLIGNY] au gentilhomme allemand... Volpert von Dersz,... qui a prins prisonnier monseigneur le connestable... Faict à Orleans, ce quatreiesme jour d'avril, l'an mil cinq cens soixante deux, avant Pasques ». Copie ; 43 Lettre de « JEHAN HIER,... à monseigneur le connestable... De Montirandel, ce VIIIe jour de juing 1563 » ; 44 « Estat de l'assignation ordonnée au tresorier de l'extraordinaire de la guerre, Me Guillaume Brochet, pour les garnisons ordinaires des païs de Picardye, Champaigne, Normandye, Bretaigne, Bourgongne, regiment du Sr Strossy et autres, entretenuz et appoinctez durant le mois de aoust 1566 » ; 45 « Le Revenu annuel de la maison de la ville de Bordeaulx, les charges ordinaires et extraordinaires qui ont accoustumé d'estre paiées sur icelluy »

1964-65 Board of Governors

The 1964-65 Board of Governors. Pictured here are those who attended the first meeting on December 8, 1964. From left to right - Front Row: E. E. Mitchelson, Niagara Falls. Mrs. J. J. Bench, St. Catharines. W. B. Gunning, Chippawa. Dr. J. A. Gibson, St. Catharines. D. G. Willmot, St. Catharines. J. M. Trott, Welland. C. B. Hill, St. Catharines. A. C. Rae, Fonthill. Back Row: E. S. Howard, Fort Erie. W. J. Freeman, Port Colborne. M. L. Swart, Thorold. C. F. Anderson, Port Colborne. W. S. Martin, Queenston. E. R. Davey, Niagara Falls. R. L. Hearn, Queenston. C. W. Morehead, Welland. S. J. Leishman, Thorold. F. H. Leslie, Chippawa. F. C. Cullimore, Chippawa. W. B. C. Burgoyne, St. Catharines. H. C. Blenkhorn, St. Catharines. M. A. Chown, St. Catharines. B. P. R. Newman, St. Catharines. R. S. Misener, St. Catharines. Missing: R. M. Schmon, Niagara on the Lake. E. J. Barbeau, St. Catharines. P. E. Roberts, Toronto. L. R. Williams, Welland.

Board of Trustees

Left to Right in clockwise fashion (Seated) B.P.R. Newman, C. Bruce Hill, Alan J. Earp (Provost), I.D. Buchanan, W.J. Marshall, Patrick Beard, H.C. Blenkhorn, H.W.M. Smith, Dr. James A. Gibson (President), D.W. Lathrop (69/70 chairman), E.R. Davey (68/69 chairman), Dr. C.A. Sankey (Chancellor), E.E. Mitchelson (Secretary), Dan Biggar, Mrs. J.J. Bench, M.L. Stwart, W.D. Chisholm, W.A. Thomas Left to Right (Standing) R.M. Schmon (Vice Chairman 69/70), E.S. Howard (Vice Chairman 69/70), S.S. MacInnes, QC (Vice Chairman 69/70)

The Three Vice Chairmen

From left to right: R. M. Schmon, E. S. Howard, S. S. MacInnes, Qc

Founders Committee

Members of the Founders' Committee. Pictured here in a clockwise fashion from the left are: R. L. Hearn, W. J. Freeman, M. A. Chown, M. L. Swart, C. Bruce Hill, C. B. Slemon, Dr. James A. Gibson, D. G. Willmot, J .M. Trott, A. C. Rae, W. B. C. Burgoyne, E. S. Howard, L. R. Williams, S. J. Leishman, E. J. Barbeau, and E. R. Davey. Missing from the photo were: W. B. Gunning, W. S. Martin, C. W. Morehead, and B. P. R. Newman.

Hurry up and slow down : education to close the ingenuity gap /

To explore the idea of education to close the ingenuity gap I use Thomas Homer-Dixon's work to define ingenuity. The notion that the supply of ingenuity to solve our technical and social problems is not keeping pace with the ingenuity required to solve those problems is called the ingenuity gap. Man-made technological developments are increasing the density, intensity, and pace of globalisation. People must reorganise decision-making organisations and problem-solving methods to pragmatically combat the growing ingenuity gap. John Dewey's work illustrates the fundamental attitudes for the thinking and judgment associated with educating for ingenuity. Howard Gardner's idea that truth, beauty, and morality ought to form the core values and tenets of the philosophy of educating for ingenuity is integral to this thesis. The act of teaching facilitates the invitation to the communication necessary to foster ingenuity. John Novak-discusses the five relationships of educational leadership that enhance an environment of ingenuity. The International Baccalaureate (IB) is an existing model of global education, one that defines some of the school experiences and academic development of core values of educating for ingenuity. Expanding upon the structure of the IB and other research within this thesis, I speculate upon what my school, where educating for ingenuity so as to close the ingenuity gap is the goal, would be like.

Teacher professional growth in an authentic learning environment

The last several decades have been marked by tremendous changes in education - technological, pedagogical, administrative, and social. These changes have led to considerable increments in the budgets devoted to professional development for teachers ~ with the express purpose of helping them accommodate their practices to the new realities oftheir classrooms. However, research has suggested that, in spite of the emphasis placed on encouraging sustained change in teaching practices, little has been accomplished. This begs the question of what ought to be done to not only reverse this outcome, but contribute to transformational change. The literature suggests some possibilities including: a) considering teachers as learners and applying what, is known about cognition and learning; b) modifying the location and nature ofprofessional development so that it is authentic, based in the classroom and focusing on tasks meaningful to the teacher; c) attending to the infrastructure underlying professional development; and d) ensuring opportunities for reflective practice. This dissertation looks at the impact of each ofthese variables through an analysis ofthe learning journeys of a group ofteachers engaged in a program called GrassRoots in one midsized school board in Ontario. Action research was conducted by the researcher in his role as consultant facilitating teacher professional growth around the use of Web sites as culminating performance tasks by students. Research focused on the pedagogical approach to the learning of the teachers involved and the infrastructure underlying their learning. Using grounded theory, a model for professional development was developed that can be used in the future to inform practices and, hopefully, lead to sustained transformational school change.

Geology of the Sand Creek porphyry molybdenum prospect /

The Sand Creek Prospect is located within the eastern exposed margin of the Coast Plutonic Complex. The occurrence is a plug and dyke porphyry molybdenum deposit. The rock types, listed in decreasing age: 1) metamorphlc schists and gneisses; 2) diorite suite rocks - diorite, quartz diorite, tonalite; 3) rocks of andesitic composition; 4) granodiorites, coarse porphyritic granodiorite, quartzfeldspar porphyry, feldspar porphyry; and 5) lamprophyre. Hydrothermal alteration is known to have resulted from emplacement of the hornblende-feldspar porphyry through to the quartz-feldspar porphyry. Molybdenum mineralization is chiefly associated with the quartz-feldspar porphyry. Ore mineralogy is dominated by pyrite with subordinate molybdenite, chalcopyrite, covelline, sphalerite, galena, scheelite, cassiterite and wolframite. Molybdenite exhibits a textural gradation outward from the quartz-feldspar porphyry. That is, disseminated rosettes and rosettes in quartz veins to fine-grained molybdenite in quartz veins and potassic altered fractures to fine-grained molybdenite paint or 6mears in the peripheral zones. The quartz-feldspar porphyry dykes were emplaced in an inhomogeneous stress field. The trend of dykes, faults and shear zones is 0^1° to 063° and dips between 58° NW and 86* SE. Joint Pole distribution reflects this fault orientation. These late deformatior maxima are probably superimposed upon annuli representing diapiric emplacement of the plutons. A model of emplacement involving two magmatic pulses is given in the following sequence: Diorite pulse (i) dioritequartz diorite, (ii) tonalites; granodiorite pulse (iii) hornblende-fildspar microporphyry, hornblende/biotite porphyry, (iv) coarse grained granodiorite, (v) quartz-feldspar porphyry, (vi) feldspar porphyry, and (vii) lamprophyre. The combination of plutonic and coarse porphyritic textures, extensive propylitic overprinting of potassic alteration assemblages suggests that the. prospect represents the lower reaches of a porphyry system.

A treatment of atomic mean square displacement in higher order perturbation theory

A general derivation of the anharmonic coefficients for a periodic lattice invoking the special case of the central force interaction is presented. All of the contributions to mean square displacement (MSD) to order 14 perturbation theory are enumerated. A direct correspondance is found between the high temperature limit MSD and high temperature limit free energy contributions up to and including 0(14). This correspondance follows from the detailed derivation of some of the contributions to MSD. Numerical results are obtained for all the MSD contributions to 0(14) using the Lennard-Jones potential for the lattice constants and temperatures for which the Monte Carlo results were calculated by Heiser, Shukla and Cowley. The Peierls approximation is also employed in order to simplify the numerical evaluation of the MSD contributions. The numerical results indicate the convergence of the perturbation expansion up to 75% of the melting temperature of the solid (TM) for the exact calculation; however, a better agreement with the Monte Carlo results is not obtained when the total of all 14 contributions is added to the 12 perturbation theory results. Using Peierls approximation the expansion converges up to 45% of TM• The MSD contributions arising in the Green's function method of Shukla and Hubschle are derived and enumerated up to and including 0(18). The total MSD from these selected contributions is in excellent agreement with their results at all temperatures. Theoretical values of the recoilless fraction for krypton are calculated from the MSD contributions for both the Lennard-Jones and Aziz potentials. The agreement with experimental values is quite good.

Beyond g : putting multiple intelligences theory to the test /

The purpose of this study was to investigate Howard Gardner's (1983) Multiple Intelligences theory, which proposes that there are eight independent intelligences: Linguistic, Spatial, Logical/Mathematical, Interpersonal, Intrapersonal, Naturalistic, Bodily-Kinesthetic, and Musical. To explore Gardner's theory, two measures of each ability area were administered to 200 participants. Each participant also completed a measure of general cognitive ability, a personality inventory, an ability self-rating scale, and an ability self-report questionnaire. Nonverbal measures were included for most intelligence domains, and a wide range of content was sampled in Gardner's domains. Results showed that all tests of purely cognitive abilities were significantly correlated with the measure of general cognitive ability, whereas Musical, Bodily-Kinesthetic, and one of the Intrapersonal measures were not. Contrary to what Multiple Intelligences theory would seem to predict, correlations among the tests revealed a positive manifold and factor analysis indicated a large factor of general intelligence, with a mathematical reasoning test and a classification task from the Naturalistic domain having the highest ^- loadings. There were only minor sex differences in performance on the ability tests. Participants' self-estimates of ability were significantly and positively correlated with actual performance in some, but not all, intelligences. With regard to personality, a hypothesized association between Openness to Experience and crystallized intelligence was supported. The implications of the findings in regards to the nature of mental abilities were discussed, and recommendations for further research were made.

The 50th reunion of the Class of 1933, Chapman College, Orange, California, May 19, 1983

The 50th reunion of the Class of 1933, Chapman College, Orange, California, May 19, 1983. First row, left to right: Ruth (Mercer) Dorrance, Toribio Castillo, Melva (Carlmark) Haskell, Felix Pascua, Henry Searle, and Lois (Huntley) Todd. Back row, left to right: Ruta (Pelley) Upham, Paul Dear, John Parker, Howard Metzger, Irvin C. "Ernie" Chapman and Tom West.