Audit report on the Iowa Federal Family Education Loan Program Division, a Division of the Iowa College Student Aid Commission, for the year ended June 30, 2012

Audit report on the Iowa Federal Family Education Loan Program Division, a Division of the Iowa College Student Aid Commission, for the year ended June 30, 2012

O rendimento da escola no Distrito Federal entre 1922 e 1935

Este artigo tem por objetivo analisar os quadros estatísticos de atendimento e rendimento das escolas públicas da cidade do Rio de Janeiro entre 1922 e 1935, publicados pela Diretoria Geral de Instrução Pública do Distrito Federal sobre a capacidade de atendimento das escolas e as taxas de repetência e evasão do sistema de ensino da cidade. A discussão central diz respeito à elaboração dos índices de matrícula, frequência e promoção das escolas cariocas durante as reformas dirigidas por Antônio de Arruda Carneiro Leão (1922-1926), Fernando de Azevedo (1927-1930) e Anísio Teixeira (1931-1935). Assim, aborda-se a produção das estatísticas oficiais para compreender a expansão da capacidade de atendimento da escola pública e a contenção da evasão e da repetência.

Induced down-regulation of neuropeptide Y-Y1 receptors delays initiation of kindling.

Neuropeptide Y appears to modulate epileptic seizures differentially according to the receptor subtypes involved. In the hippocampus, neuropeptide Y expression and release are enhanced in different models of epileptogenesis. On the contrary, the expression of Y1 receptors is decreased and it has been shown that activation of these receptors has pro-convulsant effects. The aim of our study was to investigate the role of Y1 receptors during hippocampal kindling epileptogenesis using (i) knock-out mice lacking Y1 receptors and (ii) intrahippocampal infusion of Y1 antisense oligodeoxynucleotide in rats. Y1 knock-out mice showed similar susceptibility to seizure induction and presented no difference in kindling development as compared with their control littermates. Conversely, local hippocampal down-regulation of Y1 receptors during the first week of hippocampal kindling, induced by a local infusion of a Y1 antisense oligodeoxynucleotide, significantly increased seizure threshold intensity and decreased afterdischarge duration. A reverse effect was observed during the week following the infusion period, which was confirmed by a significant decrease in the number of hippocampal stimulations necessary to evoke generalized seizures. At the end of this second week, an up-regulation of Y1 receptors was observed in kindled rats infused with the antisense as compared with the mismatch-treated controls. Our results in the rat suggest that the down-regulation of Y1 receptors in the hippocampus participates in the control of the initiation of epileptogenesis. The lack of an effect of the deficiency of Y1 receptors in the control of kindling development in Y1 knock-out mice could be due to compensatory mechanisms.

Informatização da informação: a experiência do Sistema de Bibliotecas da Universidade Federal do Rio Grande do Sul

O Sistema de Bibliotecas da Universidade Federal do Rio Grande do Sul vem desenvolvendo, desde 1988, o Sistema de Automação de Bibliotecas da UFRGS _ SABi. Este trabalho apresenta o SABi, enfatizando os recursos utilizados na sua definição e implementação, sua estrutura e sua aplicação no tratamento, recuperação e difusão dos dados bibliográficos de documentos produzidos no âmbito da universidade.

City of Oakville public assistance grants independent auditor’s reports, schedule of expenditures of federal awards, schedule of findings and questioned costs, year ended june 30, 2009.

Audit report on the City of Oakville, Iowa for the year ended June 30, 2009.

Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.

Skin morphogenesis, maintenance, and healing after wounding require complex epithelial-mesenchymal interactions. In this study, we show that for skin homeostasis, interleukin-1 (IL-1) produced by keratinocytes activates peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) expression in underlying fibroblasts, which in turn inhibits the mitotic activity of keratinocytes via inhibition of the IL-1 signaling pathway. In fact, PPARbeta/delta stimulates production of the secreted IL-1 receptor antagonist, which leads to an autocrine decrease in IL-1 signaling pathways and consequently decreases production of secreted mitogenic factors by the fibroblasts. This fibroblast PPARbeta/delta regulation of the IL-1 signaling is required for proper wound healing and can regulate tumor as well as normal human keratinocyte cell proliferation. Together, these findings provide evidence for a novel homeostatic control of keratinocyte proliferation and differentiation mediated via PPARbeta/delta regulation in dermal fibroblasts of IL-1 signaling. Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner.

MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation.

BACKGROUND: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used to assess the expression of prophylactic or therapeutic genes in animal disease models. RESULTS: In this study, we devised vectors allowing a tight regulation of transgene expression in mice from such non-viral vectors using a doxycycline-controlled network of activator and repressor proteins. Using these vectors, we demonstrate proper physiological response as consequence of the induced expression of two therapeutically relevant proteins, namely erythropoietin and utrophin. Kinetic studies showed that the induction of transgene expression was only transient, unless epigenetic regulatory elements termed Matrix Attachment Regions, or MAR, were inserted upstream of the regulated promoters. Using episomal plasmid rescue and quantitative PCR assays, we observed that similar amounts of plasmids remained in muscles after electrotransfer with or without MAR elements, but that a significant portion had integrated into the muscle fiber chromosomes. Interestingly, the MAR elements were found to promote plasmid genomic integration but to oppose silencing effects in vivo, thereby mediating long-term expression. CONCLUSIONS: This study thus elucidates some of the determinants of transient or sustained expression from the use of non-viral regulated vectors in vivo.

Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?

By regulating the metabolism of fatty acids, carbohydrates, and xenobiotic, the mammalian circadian clock plays a fundamental role on the liver physiology. At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level. However, recent evidences suggest that some signaling pathways synchronized by the circadian clock can also influence metabolism at a post-transcriptional level. In this context, we have recently shown that the circadian clock synchronizes the rhythmic activation of the IRE1alpha pathway in the endoplasmic reticulum. The absence of circadian clock perturbs this secondary clock, provokes deregulation of endoplasmic reticulum-localized enzymes, and leads to impaired lipid metabolism. We will describe here the additional pathways synchronized by the clock and discussed the influence of the circadian clock-controlled feeding rhythm on them.

Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.

The cellular response to fasting and starvation in tissues such as heart, skeletal muscle, and liver requires peroxisome proliferator-activated receptor-alpha (PPARalpha)-dependent up-regulation of energy metabolism toward fatty acid oxidation (FAO). PPARalpha null (PPARalphaKO) mice develop hyperinsulinemic hypoglycemia in the fasting state, and we previously showed that PPARalpha expression is increased in islets at low glucose. On this basis, we hypothesized that enhanced PPARalpha expression and FAO, via depletion of lipid-signaling molecule(s) for insulin exocytosis, are also involved in the normal adaptive response of the islet to fasting. Fasted PPARalphaKO mice compared with wild-type mice had supranormal ip glucose tolerance due to increased plasma insulin levels. Isolated islets from the PPARalpha null mice had a 44% reduction in FAO, normal glucose use and oxidation, and enhanced glucose-induced insulin secretion. In normal rats, fasting for 24 h increased islet PPARalpha, carnitine palmitoyltransferase 1, and uncoupling protein-2 mRNA expression by 60%, 62%, and 82%, respectively. The data are consistent with the view that PPARalpha, via transcriptionally up-regulating islet FAO, can reduce insulin secretion, and that this mechanism is involved in the normal physiological response of the pancreatic islet to fasting such that hypoglycemia is avoided.

Necessidades e expectativas dos usuários na educação a distância: estudo preliminar junto ao Programa de Pós-Graduação em Engenharia de Produção da Universidade Federal de Santa Catarina

Apresenta pesquisa que objetiva identificar necessidades e expectativas informacionais de usuários de bibliotecas acadêmicas realizada junto aos mestrandos e professores dos cursos a distância do Programa de Pós-Graduação em Engenharia de Produção da Universidade Federal de Santa Catarina, dando ênfase à qualidade em serviços. Os resultados mostram que os modelos de bibliotecas acadêmicas devem estar centrados na voz dos usuários, pois necessitam de informação para a obtenção de conhecimento, para atualização, produção de artigos científicos e dissertações. Também, esperam que as unidades informacionais disponibilizem produtos nos diversos suportes existentes, isto é, convencionais e digitais.

Correio eletrônico como recurso didático no ensino superior: o caso da Universidade Federal do Ceará

O correio eletrônico é uma aplicação popular da Internet, constituindo-se um incentivo para os professores integrarem esse recurso tecnológico em suas disciplinas, podendo ser utilizado como uma técnica para aprimoramento do ensino-aprendizagem. Algumas disciplinas de cursos de graduação e de mestrado da Universidade Federal do Ceará vêm contemplando os alunos matriculados com a utilização do correio eletrônico, com o propósito de melhorar o intercâmbio das informações entre os alunos e entre estes e os professores. Esta pesquisa teve como objetivo fundamental avaliar a opinião dos alunos sobre o uso do correio eletrônico e o sucesso instrucional proporcionado pela sua utilização. Aplicou-se um instrumento, contendo duas escalas de opinião, em uma amostra aleatória de 123 alunos de disciplinas que usam o correio eletrônico. Observou-se que somente 27,6% dos entrevistados apresentaram alto nível de concordância nos 13 itens da escala referentes à utilização do correio eletrônico como recurso. No entanto, 72,5% dos respondentes à escala com 12 itens sobre o sucesso instrucional e a troca de experiências apresentaram alto nível de concordância.

Desenvolvimento de referencial teórico para um sistema de informações gerenciais (SIG) para parlamentares e assessores na Câmara Legislativa do Distrito Federal: em busca de um modelo conceitual

Procurou-se desenvolver um referencial teórico para o desenvolvimento de um modelo conceitual de sistema de informações estratégico-administrativo de apoio à decisão, com base na análise sociotécnica estruturada. Para tanto, buscou-se analisar os fatores ambientais que influenciam o processo decisório de parlamentares e assessores na Câmara Legislativa do Distrito Federal. Como resultado, foram obtidas as relações entre organização, ambiente e dados, representadas graficamente, em um modelo conceitual de um sistema de informações gerenciais (SIG), para acompanhamento sistemático das informações que influenciam o contexto de atuação dos atores responsáveis pelo processo legislativo local.

Iowa Department of Commerce, Professional Licensing and Regulation Division Performance Report, FY 2004

Agency Performance Report

Iowa Department of Commerce, Professional Licensing and Regulation Division Performance Report, FY 2005

Agency Performance Report