Sensitivity Analysis Of The Dimensionless Parameters In Scaling A Polymer Flooding Reservoir

A set of scaling criteria of a polymer flooding reservoir is derived from the governing equations, which involve gravity and capillary force, compressibility of water, oil, and rock, non-Newtonian behavior of the polymer solution, absorption, dispersion, and diffusion, etc. A numerical approach to quantify the dominance degree of each dimensionless parameter is proposed. With this approach, the sensitivity factor of each dimensionless parameter is evaluated. The results show that in polymer flooding, the order of the sensitivity factor ranges from 10(-5) to 10(0) and the dominant dimensionless parameters are generally the ratio of the oil permeability under the condition of the irreducible water saturation to water permeability under the condition of residual oil saturation, density, and viscosity ratios between water and oil, the reduced initial oleic phase saturation and the shear rate exponent of the polymer solution. It is also revealed that the dominant dimensionless parameters may be different from case to case. The effect of some physical variables, such as oil viscosity, injection rate, and permeability, on the dominance degree of the dimensionless parameters is analyzed and the dominant ones are determined for different cases.

A generalized model for the effective thermal conductivity of porous media based on self-similarity

A generalized model for the effective thermal conductivity of porous media is derived based on the fact that statistical self-similarity exists in porous media. The proposed model assumes that porous media consist of two portions: randomly distributed non-touching particles and self-similarly distributed particles contacting each other with resistance. The latter are simulated by Sierpinski carpets with side length L = 13 and cutout size C = 3, 5, 7 and 9, respectively, depending upon the porosity concerned. Recursive formulae are presented and expressed as a function of porosity, ratio of areas, ratio of component thermal conductivities and contact resistance, and there is no empirical constant and every parameter has a clear physical meaning. The model predictions are compared with the existing experimental data, and good agreement is found in a wide range of porosity of 0.14-0.80, and this verifies the validity of the proposed model.

A geometry model for tortuosity of flow path in porous media

A simple geometry model for tortuosity of flow path in porous media is proposed based on the assumption that some particles in a porous medium are unrestrictedly overlapped and the others are not. The proposed model is expressed as a function of porosity and there is no empirical constant in this model. The model predictions are compared with those from available correlations obtained numerically and experimentally, both of which are in agreement with each other. The present model can also give the tortuosity with a good approximation near the percolation threshold. The validity of the present tortuosity model is thus verified.

Fractal dimensions for unsaturated porous media

The analytical expressions of the fractal dimensions for wetting and non-wetting phases for unsaturated porous media are derived and are found to be a function of porosity, maximum and minimum pore sizes as well as saturation. There is no empirical constant in the proposed fractal dimensions. It is also found that the fractal dimensions increase with porosity of a medium and are meaningful only in a certain range of saturation S-w, i.e. S-w > S-min for wetting phase and S-w < S-max for non-wetting phase at a given porosity, based on real porous media for requirements from both fractal theory and experimental observations. The present analysis of the fractal dimensions is verified to be consistent with the existing experimental observations and it makes possible to analyze the transport properties such as permeability, thermal dispersion in unsaturated porous media by fractal theory and technique.

Effects of physical parameter range on dimensionless variable sensitivity in water flooding reservoirs

The similarity criterion for water flooding reservoir flows is concerned with in the present paper. When finding out all the dimensionless variables governing this kind of flow, their physical meanings are subsequently elucidated. Then, a numerical approach of sensitivity analysis is adopted to quantify their corresponding dominance degree among the similarity parameters. In this way, we may finally identify major scaling law in different parameter range and demonstrate the respective effects of viscosity, permeability and injection rate.

Effects of physical parameter range on dimensionless variable sensitivity in water flooding reservoirs

The similarity criterion for water flooding reservoir flows is concerned with in the present paper. When finding out all the dimensionless variables governing this kind of flow, their physical meanings are subsequently elucidated. Then, a numerical approach of sensitivity analysis is adopted to quantify their corresponding dominance degree among the similarity parameters. In this way, we may finally identify major scaling law in different parameter range and demonstrate the respective effects of viscosity, permeability and injection rate.

岩石爆炸增渗模型实验及DEM数值模拟研究

岩体中爆炸提高矿石的渗透性可以极大地提高采矿效率，是碎裂岩型矿床预裂浸出法的关键技术。混凝土与岩体都具有脆性材料的特性，因此用浇筑于铁桶中的混凝土试件进行模型实验研究岩体的爆炸增渗效果。铁桶可以提高实验效率，使边界条件更为简单和易于操作，但是，实验和原型的差异需要论证。用自主开发的基于连续介质力学模型的离散元方法，模拟了有铁桶边界的模型实验，验证了数值模拟方法的可行性及有效性，给出了有弹性侧限边界约束的混凝土和较大尺度无反射边界条件的岩石中的爆炸差别。在此基础上，分析了岩石中爆炸造成的岩石破坏规律。计算结果表明：岩石破坏面总面积和破坏区的最大裂缝宽度受药量和岩石的抗拉强度影响，破坏面总面积和裂缝宽度随药量增加而增大，随抗拉强度增大而减小；在药量相同的条件下，实际岩石环境下的岩块破坏程度比铁桶约束的大。模型实验和数值模拟相结合的办法可以对混凝土和岩石的爆炸破坏给出较为合理的结果。

低渗透油藏渗吸法采油的数值模拟

针对渗吸法采油中的毛管力驱动项和流动系数的取值问题，根据地下流体渗流特征，建立了低渗透油藏渗吸法采油数学模型，给出了数值解法．定量分析了渗吸法采油的主要影响因素，通过实例验证，用该方法计算的各项动态指标与矿场实际值符合程度较高．结果表明：基质与裂缝渗透率之比小于O．Ol，油水黏度比小于15，毛管力较大的水湿油层比较适合于渗吸法采油，能够提高水驱采收率2％左右．

The Effects of Backfill Soil Properties on Wave-induced Pore Pressures around a Trenched Pipeline

Offshore pipelines are always trenched into seabed to reduce wave-induced forces and thereby to enhance their stability. The trenches are generally backfilled either by in-site sediments or by depositing selected backfill materials over the pipeline from bottom-dump barge. The actual waves in shallow water zone are always characterized as nonlinear. The proper evaluation of the wave-induced pressures upon pipeline is important for coastal geotechnical engineers. However, most previous investigations of the wave–seabed–pipe interaction problem have been concerned only with a single sediment layer and linear wave loading. In this paper, based on Biot’s consolidation theory, a two-dimensional finite element model is developed to investigate non-linear wave induced pore pressures around trenched pipeline. The influences of the permeability of backfill soil and the geometry profiles of trenches upon soil responses around pipeline are studied respectively.

Simulation of Natural Gas Production in Hydrate Reservoirs

This paper simulates a one-dimensional physical model of natural gas production from hydrate dissociation in a reservoir by depressurization. According to the principles of solid hydrate decomposition in stratum and flow of natural gas in porous medium, the pressure governing equations for both gas zone and hydrate zone are set up based on the physical production model. Using the approximation reported by N. N. Verigin et al. (1980), the nonlinear governing equations are simplified and the self-similar solutions are obtained. Through calculation, for different reservoir parameters, the distribution characters of pressure are analyzed. The decline trend of natural gas production rate with time is also studied. The simulation results show that production of natural gas from a hydrate reservoir is very sensitive to several reservoir parameters, such as wellbore pressure and stratum porosity and permeability.

A New Model for Sediment Transport

The problem of predicting sediment transportation by water waves is treated analytically with the rate of wave energy dissipation or wave damping. With resorting to the theory of shallow water waves and the basis of Yamamoto’s Coulomb-damped poroelastic model, the Boussinesq-type equation has been derived over a variation depth bed. For convenience Cnoidal wave is just discussed, The Cnoidal wave with complex wave length and wave velocity, which are as a function of wave frequency, water depth, permeability, Poisson’s ratio and complex elastic moduli of bed soil, is applied to analyse the rate of sediment transportation. Considering the sediment transportation depended on the shear stress near-bed or the horizontal velocity, the conclusion of Yamamoto’s experiment in clay bed has been extended to general situation. It could be figured out that the model should provide a method to avoid the undistinguishable factors during sediment transport processes and relate mass transport with the sediment peculiarities.

Comparisons of static, quasi-static and dynamic 3D porous media scale network models for two-phase immiscible flow in porous media

A dynamic 3D pore-scale network model is formulated for investigating the effect of interfacial tension and oil-water viscosity during chemical flooding. The model takes into account both viscous and capillary forces in analyzing the impact of chemical properties on flow behavior or displacement configuration, while the static model with conventional invasion percolation algorithm incorporates the capillary pressure only. From comparisons of simulation results from these models. it indicates that the static pore scale network model can be used successfully when the capillary number is low. With the capillary increases due to the enhancement of water viscosity or decrease of interfacial tension, only the quasi-static and dynamic model can give insight into the displacement mechanisms.

Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting. While it has similar activity when compared to other anti-EGFR antibodies, it does not induce skin toxicity or hypomagnesemia. Methods A randomized, double blind, multicentric clinical trial was conducted in high grade glioma patients (41 anaplastic astrocytoma and 29 glioblastoma multiforme) that received radiotherapy plus nimotuzumab or placebo. Treatment and placebo groups were well-balanced for the most important prognostic variables. Patients received 6 weekly doses of 200 mg nimotuzumab or placebo together with irradiation as induction therapy. Maintenance treatment was given for 1 year with subsequent doses administered every 3 weeks. The objectives of this study were to assess the comparative overall survival, progression free survival, response rate, immunogenicity and safety. Results The median cumulative dose was 3200 mg of nimotuzumab given over a median number of 16 doses. The combination of nimotuzumab and RT was well-tolerated. The most prevalent related adverse reactions included nausea, fever, tremors, anorexia and hepatic test alteration. No anti-idiotypic response was detected, confirming the antibody low immunogenicity. The mean and median survival time for subjects treated with nimotuzumab was 31.06 and 17.76 vs. 21.07 and 12.63 months for the control group. Conclusions In this randomized trial, nimotuzumab showed an excellent safety profile and significant survival benefit in combination with irradiation.

Investigation of unusual mortalities of bottlenose dolphins along the mid-Texas coastal bay ecosystem during 1992

An investigation was conducted into the deaths of more than 220 bottlenose dolphins (Tursiops truncatus) that occurred within the coastal bay ecosystem of mid-Texas between January and May 1992. The high mortality rate was unusual in that it was limited to a relatively small geographical area, occurred primarily within an inshore bay system separated from the Gulf of Mexico by barrier islands, and coincided with deaths of other taxa including birds and fish. Factors examined to determine the potential causes of the dolphin mortalities included microbial pathogens, natural biotoxins, industrial pollutants, other environmental contaminants, and direct human interactions. Emphasis was placed on nonpoint source pesticide runoff from agricultural areas, which had resulted from record rainfall that occurred during the period of increased mortality. Analytical results from sediment, water, and biota indicated that biotoxins, trace metals, and industrial chemical contamination were not likely causative factors in this mortality event. Elevated concentrations of pesticides (atrazine and aldicarb) were detected in surface water samples from bays within the region, and bay salinities were reduced to <10 ppt from December 1991 through April 1992 due to record rainfall and freshwater runoff exceeding any levels since 1939. Prolonged exposure to low salinity could have played a significant role in the unusual mortalities because low salinity exposure may cause disruption of the permeability barrier in dolphin skin. The lack of established toxicity data for marine mammals, particularly dermal absorption and bioaccumulation, precludes accurate toxicological interpretation of results beyond a simple comparison to terrestrial mammalian models. Results clearly indicated that significant periods of agricultural runoff and accompanying low salinities co-occurred with the unusual mortality event in Texas, but no definitive cause of the mortalities was determined. (PDF file contains 25 pages.)

Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

[EN] The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to 24 enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV drug 25 and P-gp substrate as a model drug, and (ii) to study NLC transport mechanisms across the intestinal barrier. 26 Three different NLC formulations were evaluated. SQV transport across Caco-2 monolayers was enhanced up 27 to 3.5-fold by NLCs compared to SQV suspension. M cells did not enhance the transport of NLCs loaded with 28 SQV. The size and amount of surfactant in the NLCs influenced SQV's permeability, the transcytosis pathway 29 and the efflux of SQV by P-gp. An NLC of size 247 nm and 1.5% (w/v) surfactant content circumvented P-gp 30 efflux and used both caveolae- and clathrin-mediated transcytosis, in contrast to the other NLC formulations, 31 which used only caveolae-mediated transcytosis. By modifying critical physicochemical parameters of the 32 NLC formulation, we were thus able to overcome the P-gp drug efflux and alter the transcytosis mechanism 33 of the nanoparticles. These findings support the use of NLCs approaches for oral delivery of poorly 34 water-soluble P-gp substrates.