Celiac disease in the Mediterranean area

Background: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy. Methods: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers. Results: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol. Conclusions: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines.

Carta enviada por Miguel Arutza a Justo Garate en 1960

1 carta (mecanografiada) ; 137x214mm. Ubicación: Caja 1 - Carpeta 68

The age and growth of the tongue sole Cynoglossus canariensis (Steind 1882)

The geometric mean regression equation for the weight; length relationship of Cynoglossus canariensis was W = 0.0025 L super(3.1770). The Von Bertalanffy constants Woo, Loo, K, and to were 507.5852 g, 47.3683 cm, 0.3333 and 0.1397 for males and 839.0753 g, 54.4720 cm, 0.3062 and 0.1737 for females. Total mortality coefficient Z ranged from 0.6482 and 0.8021

A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report

Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are molecularly classified according to the abnormal prion protein (PrPSc) conformations along with polymorphism of codon 129 of the PRNP gene. Recently, a novel human disease, termed "protease-sensitive prionopathy", has been described. This disease shows a distinct clinical and neuropathological phenotype and it is associated to an abnormal prion protein more sensitive to protease digestion. Case presentation: We report the case of a 75-year-old-man who developed a clinical course and presented pathologic lesions compatible with sporadic Creutzfeldt-Jakob disease, and biochemical findings reminiscent of "protease-sensitive prionopathy". Neuropathological examinations revealed spongiform change mainly affecting the cerebral cortex, putamen/globus pallidus and thalamus, accompanied by mild astrocytosis and microgliosis, with slight involvement of the cerebellum. Confluent vacuoles were absent. Diffuse synaptic PrP deposits in these regions were largely removed following proteinase treatment. PrP deposition, as revealed with 3F4 and 1E4 antibodies, was markedly sensitive to pre-treatment with proteinase K. Molecular analysis of PrPSc showed an abnormal prion protein more sensitive to proteinase K digestion, with a five-band pattern of 28, 24, 21, 19, and 16 kDa, and three aglycosylated isoforms of 19, 16 and 6 kDa. This PrPSc was estimated to be 80% susceptible to digestion while the pathogenic prion protein associated with classical forms of sporadic Creutzfeldt-Jakob disease were only 2% (type VV2) and 23% (type MM1) susceptible. No mutations in the PRNP gene were found and genotype for codon 129 was heterozygous methionine/valine. Conclusions: A novel form of human disease with abnormal prion protein sensitive to protease and MV at codon 129 was described. Although clinical signs were compatible with sporadic Creutzfeldt-Jakob disease, the molecular subtype with the abnormal prion protein isoforms showing enhanced protease sensitivity was reminiscent of the "protease-sensitive prionopathy". It remains to be established whether the differences found between the latter and this case are due to the polymorphism at codon 129. Different degrees of proteinase K susceptibility were easily determined with the chemical polymer detection system which could help to detect proteinase-susceptible pathologic prion protein in diseases other than the classical ones.

Cartas enviadas por Julio Atucha a Justo Garate entre 1968 y 1989

7 cartas y 1 tarjeta postal (mecanografiadas y manuscritas) ; entre 215x275mm y 160x112mm. Ubicación: Caja 1 - Carpeta 75

Tarjeta enviada por R. Azkue a Justo Garate en 1925

1 tarjeta (manuscrita) ; 136x92mm. Ubicación: Caja 1 - Carpeta 83

Design, analysis and implementation of a versatile low level radio frequency system for accelerating cavities

179 p.

Estadificación ganglionar (N) no invasiva en el cáncer de pulmón (no pequeñas células)

97 p. : il.

Las organizaciones juveniles del nacionalismo vasco: política, cultura y ocio (1893-1923)

909 p.

Luis Badosa: vida y obra. Aproximación a la obra pictórica a través de su vivencia

487 p. : il., col.

Kontrol esparruan ikasketa eta garapenerako oinarrizko ingurune praktiko, ireki eta askea

Embedded system design (VHDL description) based on Xilinx's Spartan3E Development Kit to perform real-time PID control and monitoring of DC motors.

Caracterización del medio supergénico en el yacimiento Ni-Cu (PGE) de Aguablanca, SW Iberia. Redistribución de metales base y PGE

1 v. (pág. var.)

Euskal nazionalismoaren diskurtsoa gaur egungo immigrazioaren aurrean

340 p.

Evaluar la calidad de vida de los cuidadores en enfermos de Alzheimer

[ES]Los cambios sociodemográficos y el aumento de la esperanza de vida han dado lugar a un aumento de algunas enfermedades, incluyendo la enfermedad de Alzheimer. La enfermedad de Alzheimer no sólo afecta a la persona que padece dicha enfermedad, sino que también repercute en la familia. Los cuidadores familiares son los que, de manera mayoritaria, se hacen cargo de la atención de estos pacientes con un compromiso de 24 horas, con lo que implica hacer cambios en sus estilos de vida. Los objetivos de este estudio son describir las características socio-demográficas, determinar la sobrecarga de los cuidadores informales y evaluar la calidad de sueño de los cuidadores. Se realizará un estudio transversal que incluirá a 40 cuidadores de enfermos de Alzheimer, seleccionados por un muestreo no probabilístico de selección por cuotas. Los participantes serán los cuidadores informales de pacientes con la enfermedad de Alzheimer que estén en el estadío III o IV de dicha enfermedad. Nuestra variable dependiente será el sueño y como variable independiente la sobrecarga. El estudio se realizará en la asociación de familiares de Alzheimer de Bilbao (A.F.A - Bizkaia), dónde se captará a la muestra de estudio y donde se procederá a aplicar los cuestionarios pertinentes para dicho estudio. Para participar en el estudio es necesario que firmen el consentimiento informado. Los instrumentos que se utilizarán son el cuestionario de Pittsburg que evalúa la calidad de sueño y la escala de carga de Zarit. Para el análisis de datos se utilizará el programa SPSS 15.0. Palabras clave: enfermedad de Alzheimer, cuidadores, cuidadores familiares, demencia, sobrecarga, sueño.

Ba al dago erlaziorik osasun profesionalek genero biolentzian duten heziketa eta egiten dituzten kasuen detekzioaren artean? Ebidentzian oinarrituriko analisia.

Genero biolentziaren biktima diren emakume kasuak detektatu eta aurre egiteko osasun langileek daukaten garrantzia nabaria da. Helburua: argitaraturik dagoen bibliografiaren berrikuspen kritikoa eginez, erizainek eta bestelako osasun langileek genero biolentzian duten heziketa mailak kasuen detekzioan erlaziorik dagoen edo ez behatzea da. Metodologia: lehenik eta behin gaia finkatzeko asmoz bilaketa bibliografiko orokorra egin da. Ondoren, gai zehatzaren inguruko bibliografia bilaketa kritikoa egin da datu base desberdinetan. Lorturiko bibliografia guztitik aukeraketa egin eta azkenean hautatutakoekin gaia landu eta azkenik lanaren erredakzioa burutu da. Emaitzak eta diskusioa: Genero biolentzia kasuen detekzioa osasun profesionalek arlo horretan daukaten formazioarekin erlazionatzen da. Hala ere, orokorrean gehienek ez dute haien burua zera egiteko guztiz gai ikusten, beste batzuen artean formazio faltaren oztopoa sumatzeko dutelako. Ondorioak: genero biolentzian osasun profesionalek formazioa izatea ezinbestekoa da kasuen detekzio egokia burutzeko. Horrela, heziketa maila handituz, osasun profesionalek detekzioa egiteko gai izango dira, kasuen maneiu hobea lortuz.