Las estanterías virtuales : un nuevo espacio en el aula

La Biblioteca de la Universitat Oberta de Catalunya ve oferint des de fa diversos semestres les anomenades Prestatgeries virtuals, un servei que se situa dins de l'aula virtual i que serveix per posar a disposició dels estudiants tota una sèrie de recursos documental que li faciliten el seguiment i aprenentatge de les assignatures a les quals està matriculat.

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.

Posibles consecuencias de la transposición de la Directiva 2001/29/CE para las bibliotecas

La present comunicació analitza les implicacions legals que des d'un punt de vista del dret d'autor tenen els actes d'explotació que duen a terme les biblioteques amb les obres que integren els seus fons, així com els límits que necessitem veure reflectits en el marc legal estatal per poder continuar duent-les a terme. Tot això a la llum dels canvis legals que la transposició de la Directiva 2001/29/CE relativa a l'harmonització de determinats aspectes dels drets d'autor i drets afins als drets d'autor en la societat de la informació suposarà.

La Biblioteca de la UOC : continguts digitals per a una biblioteca virtual

En aquesta comunicació, farem un repàs dels continguts digitals que actualment conformen el fons de la Biblioteca de la UOC. Parlar de continguts digitals a la Biblioteca de la UOC implica necessàriament recordar que la nostra biblioteca es defineix a si mateixa com a virtual, una virtualitat caracteritzada per la possibilitat oferta als nostres usuaris d'accedir remotament a continguts i serveis bibliotecaris, en què es combinen notícies bibliogràfiques, textos electrònics, bancs d'imatges i tota mena d'informacions per mitjà d'una xarxa telemàtica. La relació entre continguts digitals i virtualitat és, evidentment, directa: els serveis que s'ofereixen virtualment es fan sobre la base de documents digitals i, al mateix temps, aquests serveis virtuals també generen documents electrònics.

The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis

Histoplasma capsulatum is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H. capsulatum to phagocytes may be mediated by the pathogen's cell wall carbohydrates, glucans, which consist of glucose homo and hetero-polymers and whose glycosydic linkage types differ between the yeast and mycelial phases. The ±-1,3-glucan is considered relevant for H. capsulatum virulence, whereas the ²-1,3-glucan is antigenic and participates in the modulation of the host immune response. H. capsulatum cell wall components with lectin-like activity seem to interact with the host cell surface, while host membrane lectin-like receptors can recognize a particular fungal carbohydrate ligand. This review emphasizes the relevance of the main H. capsulatum and host carbohydrate-driven interactions that allow for binding and internalization of the fungal cell into phagocytes and its subsequent avoidance of intracellular elimination.

Role of Leptin in the Activation of Immune Cells

Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines. Thus, leptin is a mediator of the inflammatory response